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Article: Deregulation of Frizzled Receptors in Hepatocellular Carcinoma
Title | Deregulation of Frizzled Receptors in Hepatocellular Carcinoma |
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Authors | |
Keywords | Frizzled receptors G protein-coupled receptors Wnt signaling hepatocellular carcinoma |
Issue Date | 2018 |
Publisher | Molecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms |
Citation | International Journal of Molecular Sciences, 2018, v. 19 n. 1, article no. E313 How to Cite? |
Abstract | G protein-coupled receptors (GPCRs) have a substantial role in tumorigenesis and are described as a 'cancer driver'. Aberrant expression or activation of GPCRs leads to the deregulation of downstream signaling pathways, thereby promoting cancer progression. In hepatocellular carcinoma (HCC), the Wnt signaling pathway is frequently activated and it is associated with an aggressive HCC phenotype. Frizzled (FZD) receptors, a family member of GPCRs, are known to mediate Wnt signaling. Accumulating findings have revealed the deregulation of FZD receptors in HCC and their functional roles have been implicated in HCC progression. Given the important role of FZD receptors in HCC, we summarize here the expression pattern of FZD receptors in HCC and their corresponding functional roles during HCC progression. We also further review and highlight the potential targeting of FZD receptors as an alternative therapeutic strategy in HCC. |
Persistent Identifier | http://hdl.handle.net/10722/254922 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 1.179 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chan, KK | - |
dc.contributor.author | Lo, CLR | - |
dc.date.accessioned | 2018-06-21T01:08:40Z | - |
dc.date.available | 2018-06-21T01:08:40Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | International Journal of Molecular Sciences, 2018, v. 19 n. 1, article no. E313 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | http://hdl.handle.net/10722/254922 | - |
dc.description.abstract | G protein-coupled receptors (GPCRs) have a substantial role in tumorigenesis and are described as a 'cancer driver'. Aberrant expression or activation of GPCRs leads to the deregulation of downstream signaling pathways, thereby promoting cancer progression. In hepatocellular carcinoma (HCC), the Wnt signaling pathway is frequently activated and it is associated with an aggressive HCC phenotype. Frizzled (FZD) receptors, a family member of GPCRs, are known to mediate Wnt signaling. Accumulating findings have revealed the deregulation of FZD receptors in HCC and their functional roles have been implicated in HCC progression. Given the important role of FZD receptors in HCC, we summarize here the expression pattern of FZD receptors in HCC and their corresponding functional roles during HCC progression. We also further review and highlight the potential targeting of FZD receptors as an alternative therapeutic strategy in HCC. | - |
dc.language | eng | - |
dc.publisher | Molecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms | - |
dc.relation.ispartof | International Journal of Molecular Sciences | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Frizzled receptors | - |
dc.subject | G protein-coupled receptors | - |
dc.subject | Wnt signaling | - |
dc.subject | hepatocellular carcinoma | - |
dc.title | Deregulation of Frizzled Receptors in Hepatocellular Carcinoma | - |
dc.type | Article | - |
dc.identifier.email | Chan, KK: kuiasdf@hkucc.hk | - |
dc.identifier.email | Lo, CLR: loregina@hku.hk | - |
dc.identifier.authority | Lo, CLR=rp01359 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3390/ijms19010313 | - |
dc.identifier.pmid | 29361730 | - |
dc.identifier.pmcid | PMC5796257 | - |
dc.identifier.scopus | eid_2-s2.0-85040914014 | - |
dc.identifier.hkuros | 285481 | - |
dc.identifier.hkuros | 290170 | - |
dc.identifier.volume | 19 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | article no. E313 | - |
dc.identifier.epage | article no. E313 | - |
dc.identifier.isi | WOS:000424407200304 | - |
dc.publisher.place | Switzerland | - |
dc.identifier.issnl | 1422-0067 | - |