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Article: Unique Roles of the Non-identical MCM Subunits in DNA Replication Licensing

TitleUnique Roles of the Non-identical MCM Subunits in DNA Replication Licensing
Authors
Zhai, YuanliangLi, NingningJiang, HanlunHuang, XuhuiGao, NingTye, Bik Kwoon
KeywordsDNA replication initiation
Mcm2–7
ORC-Cdc6-Cdt1-MCM
cryo-EM structures
Acrobat Model for pre-RC assembly
Issue Date2017
Citation
Molecular Cell, 2017, v. 67, n. 2, p. 168-179 How to Cite?
DOI: http://dx.doi.org/10.1016/j.molcel.2017.06.016
Abstract© 2017 Elsevier Inc. A family of six homologous subunits, Mcm2, -3, -4, -5, -6, and -7, each with its own unique features, forms the catalytic core of the eukaryotic replicative helicase. The necessity of six similar but non-identical subunits has been a mystery since its initial discovery. Recent cryo-EM structures of the Mcm2–7 (MCM) double hexamer, its precursors, and the origin recognition complex (ORC)-Cdc6-Cdt1-Mcm2–7 (OCCM) intermediate showed that each of these subunits plays a distinct role in orchestrating the assembly of the pre-replication complex (pre-RC) by ORC-Cdc6 and Cdt1.
Persistent Identifierhttp://hdl.handle.net/10722/255990
ISSN
1097-2765
2023 Impact Factor: 14.5
2023 SCImago Journal Rankings: 9.332
ISI Accession Number ID
WOS:000405908100003

 

DC FieldValueLanguage
dc.contributor.authorZhai, Yuanliang-
dc.contributor.authorLi, Ningning-
dc.contributor.authorJiang, Hanlun-
dc.contributor.authorHuang, Xuhui-
dc.contributor.authorGao, Ning-
dc.contributor.authorTye, Bik Kwoon-
dc.date.accessioned2018-07-16T06:14:16Z-
dc.date.available2018-07-16T06:14:16Z-
dc.date.issued2017-
dc.identifier.citationMolecular Cell, 2017, v. 67, n. 2, p. 168-179-
dc.identifier.issn1097-2765-
dc.identifier.urihttp://hdl.handle.net/10722/255990-
dc.description.abstract© 2017 Elsevier Inc. A family of six homologous subunits, Mcm2, -3, -4, -5, -6, and -7, each with its own unique features, forms the catalytic core of the eukaryotic replicative helicase. The necessity of six similar but non-identical subunits has been a mystery since its initial discovery. Recent cryo-EM structures of the Mcm2–7 (MCM) double hexamer, its precursors, and the origin recognition complex (ORC)-Cdc6-Cdt1-Mcm2–7 (OCCM) intermediate showed that each of these subunits plays a distinct role in orchestrating the assembly of the pre-replication complex (pre-RC) by ORC-Cdc6 and Cdt1.-
dc.languageeng-
dc.relation.ispartofMolecular Cell-
dc.subjectDNA replication initiation-
dc.subjectMcm2–7-
dc.subjectORC-Cdc6-Cdt1-MCM-
dc.subjectcryo-EM structures-
dc.subjectAcrobat Model for pre-RC assembly-
dc.titleUnique Roles of the Non-identical MCM Subunits in DNA Replication Licensing-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.molcel.2017.06.016-
dc.identifier.pmid28732205-
dc.identifier.scopuseid_2-s2.0-85025177584-
dc.identifier.hkuros288598-
dc.identifier.volume67-
dc.identifier.issue2-
dc.identifier.spage168-
dc.identifier.epage179-
dc.identifier.eissn1097-4164-
dc.identifier.isiWOS:000405908100003-
dc.identifier.issnl1097-2765-

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