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Conference Paper: Obstructive sleep apnoea and incident diabetes mellitus in a Chinese population
Title | Obstructive sleep apnoea and incident diabetes mellitus in a Chinese population |
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Authors | |
Issue Date | 2017 |
Publisher | European Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com |
Citation | European Respiratory Society (ERS) International Congress 2017, Milan Italy, 9-13 September 2017. In European Respiratory Journal, 2017, v. 50 n. Suppl. 61, p. PA 1185 How to Cite? |
Abstract | Background: Although clinical and epidemiological studies have reported an association between obstructive sleep apnoea (OSA) and diabetes mellitus (DM), the results remain inconsistent.
Objective: To evaluate the role of OSA on the incidence of DM in a Chinese cohort.
Methods: This is a retrospective cohort study, the eligible subjects were drawn from those who received in-laboratory sleep studies between 01/01/2007 and 31/12/2010 in the Department of Medicine, Queen Mary Hospital. Only those without DM at the time of polysomnogram were included. Follow-up data were drawn from the Hospital Authority Clinical Management System up to the day of data entry in this study. Apnoea-hypopnea index (AHI) was used in the Cox-regression model, adjusting for age, gender, body mass index (BMI), neck, waist and hip circumference, daytime sleepiness (Epworth sleepiness scale score) and prior cardiometabolic comorbidities.
Findings: 107 (14.3%) of 749 subjects developed DM over a median follow-up of 87 months, giving an incident rate of 2.0 per 100 person-years. In fully adjusted models, AHI as a categorical variable, severe and mild+moderate OSA patients were observed to have 4.0 (95%CI 1.720-9.298) and 2.7 (95%CI 1.254-5.933) times higher hazard to develop DM, while when AHI was a continuous variable, higher AHI was also associated with increased DM risk (HR=1.014, 95% CI 1.005-1.023).
Conclusion: AHI as a measure of OSA severity predicted incident diabetes independent of obesity. |
Persistent Identifier | http://hdl.handle.net/10722/256457 |
ISSN | 2023 Impact Factor: 16.6 2023 SCImago Journal Rankings: 3.810 |
DC Field | Value | Language |
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dc.contributor.author | Xu, P | - |
dc.contributor.author | Lui, MSM | - |
dc.contributor.author | Lam, CLD | - |
dc.contributor.author | Ip, MSM | - |
dc.contributor.author | Fong, DYT | - |
dc.contributor.author | Hui, KMC | - |
dc.date.accessioned | 2018-07-20T06:34:58Z | - |
dc.date.available | 2018-07-20T06:34:58Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | European Respiratory Society (ERS) International Congress 2017, Milan Italy, 9-13 September 2017. In European Respiratory Journal, 2017, v. 50 n. Suppl. 61, p. PA 1185 | - |
dc.identifier.issn | 0903-1936 | - |
dc.identifier.uri | http://hdl.handle.net/10722/256457 | - |
dc.description.abstract | Background: Although clinical and epidemiological studies have reported an association between obstructive sleep apnoea (OSA) and diabetes mellitus (DM), the results remain inconsistent. Objective: To evaluate the role of OSA on the incidence of DM in a Chinese cohort. Methods: This is a retrospective cohort study, the eligible subjects were drawn from those who received in-laboratory sleep studies between 01/01/2007 and 31/12/2010 in the Department of Medicine, Queen Mary Hospital. Only those without DM at the time of polysomnogram were included. Follow-up data were drawn from the Hospital Authority Clinical Management System up to the day of data entry in this study. Apnoea-hypopnea index (AHI) was used in the Cox-regression model, adjusting for age, gender, body mass index (BMI), neck, waist and hip circumference, daytime sleepiness (Epworth sleepiness scale score) and prior cardiometabolic comorbidities. Findings: 107 (14.3%) of 749 subjects developed DM over a median follow-up of 87 months, giving an incident rate of 2.0 per 100 person-years. In fully adjusted models, AHI as a categorical variable, severe and mild+moderate OSA patients were observed to have 4.0 (95%CI 1.720-9.298) and 2.7 (95%CI 1.254-5.933) times higher hazard to develop DM, while when AHI was a continuous variable, higher AHI was also associated with increased DM risk (HR=1.014, 95% CI 1.005-1.023). Conclusion: AHI as a measure of OSA severity predicted incident diabetes independent of obesity. | - |
dc.language | eng | - |
dc.publisher | European Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com | - |
dc.relation.ispartof | European Respiratory Journal | - |
dc.relation.ispartof | European Respiratory Society International Congress 2017 | - |
dc.title | Obstructive sleep apnoea and incident diabetes mellitus in a Chinese population | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Lui, MSM: drmslui@hku.hk | - |
dc.identifier.email | Lam, CLD: dcllam@hku.hk | - |
dc.identifier.email | Ip, MSM: msmip@hku.hk | - |
dc.identifier.email | Fong, DYT: dytfong@hku.hk | - |
dc.identifier.email | Hui, KMC: chris.hui@hku.hk | - |
dc.identifier.authority | Lam, CLD=rp01345 | - |
dc.identifier.authority | Ip, MSM=rp00347 | - |
dc.identifier.authority | Fong, DYT=rp00253 | - |
dc.identifier.authority | Hui, KMC=rp01839 | - |
dc.identifier.doi | 10.1183/1393003.congress-2017.PA1185 | - |
dc.identifier.hkuros | 286265 | - |
dc.identifier.volume | 50 | - |
dc.identifier.issue | Suppl. 61 | - |
dc.identifier.spage | PA 1185 | - |
dc.identifier.epage | PA 1185 | - |
dc.publisher.place | Switzerland | - |
dc.identifier.issnl | 0903-1936 | - |