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- Publisher Website: 10.1016/j.vaccine.2018.06.007
- Scopus: eid_2-s2.0-85048072799
- WOS: WOS:000437997300007
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Article: Protection by universal influenza vaccine is mediated by memory CD4 T cells
Title | Protection by universal influenza vaccine is mediated by memory CD4 T cells |
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Authors | |
Keywords | IL-15 Influenza virus T cells Universal vaccine Vaccinia |
Issue Date | 2018 |
Publisher | Elsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccine |
Citation | Vaccine, 2018, v. 36 n. 29, p. 4198-4206 How to Cite? |
Abstract | There is a diverse array of influenza viruses which circulate between different species, reassort and drift over time. Current seasonal influenza vaccines are ineffective in controlling these viruses. We have developed a novel universal vaccine which elicits robust T cell responses and protection against diverse influenza viruses in mouse and human models. Vaccine mediated protection was dependent on influenza-specific CD4+ T cells, whereby depletion of CD4+ T cells at either vaccination or challenge time points significantly reduced survival in mice. Vaccine memory CD4+ T cells were needed for early antibody production and CD8+ T cell recall responses. Furthermore, influenza-specific CD4+ T cells from vaccination manifested primarily Tfh and Th1 profiles with anti-viral cytokine production. The vaccine boosted H5-specific T cells from human PBMCs, specifically CD4+ and CD8+ T effector memory type, ensuring the vaccine was truly universal for its future application. These findings have implications for the development and optimization of T cell activating vaccines for universal immunity against influenza. |
Persistent Identifier | http://hdl.handle.net/10722/258394 |
ISSN | 2023 Impact Factor: 4.5 2023 SCImago Journal Rankings: 1.342 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Doak, SA | - |
dc.contributor.author | Li, TW | - |
dc.contributor.author | Li, PYA | - |
dc.contributor.author | BULL, MB | - |
dc.contributor.author | Waldmann, TA | - |
dc.contributor.author | Perera, LP | - |
dc.contributor.author | Peiris, JSM | - |
dc.contributor.author | Poon, LML | - |
dc.date.accessioned | 2018-08-22T01:37:46Z | - |
dc.date.available | 2018-08-22T01:37:46Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Vaccine, 2018, v. 36 n. 29, p. 4198-4206 | - |
dc.identifier.issn | 0264-410X | - |
dc.identifier.uri | http://hdl.handle.net/10722/258394 | - |
dc.description.abstract | There is a diverse array of influenza viruses which circulate between different species, reassort and drift over time. Current seasonal influenza vaccines are ineffective in controlling these viruses. We have developed a novel universal vaccine which elicits robust T cell responses and protection against diverse influenza viruses in mouse and human models. Vaccine mediated protection was dependent on influenza-specific CD4+ T cells, whereby depletion of CD4+ T cells at either vaccination or challenge time points significantly reduced survival in mice. Vaccine memory CD4+ T cells were needed for early antibody production and CD8+ T cell recall responses. Furthermore, influenza-specific CD4+ T cells from vaccination manifested primarily Tfh and Th1 profiles with anti-viral cytokine production. The vaccine boosted H5-specific T cells from human PBMCs, specifically CD4+ and CD8+ T effector memory type, ensuring the vaccine was truly universal for its future application. These findings have implications for the development and optimization of T cell activating vaccines for universal immunity against influenza. | - |
dc.language | eng | - |
dc.publisher | Elsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccine | - |
dc.relation.ispartof | Vaccine | - |
dc.subject | IL-15 | - |
dc.subject | Influenza virus | - |
dc.subject | T cells | - |
dc.subject | Universal vaccine | - |
dc.subject | Vaccinia | - |
dc.title | Protection by universal influenza vaccine is mediated by memory CD4 T cells | - |
dc.type | Article | - |
dc.identifier.email | Doak, SA: sophiev@hku.hk | - |
dc.identifier.email | Peiris, JSM: malik@hkucc.hku.hk | - |
dc.identifier.email | Poon, LML: llmpoon@hkucc.hku.hk | - |
dc.identifier.authority | Doak, SA=rp02141 | - |
dc.identifier.authority | Peiris, JSM=rp00410 | - |
dc.identifier.authority | Poon, LML=rp00484 | - |
dc.identifier.doi | 10.1016/j.vaccine.2018.06.007 | - |
dc.identifier.scopus | eid_2-s2.0-85048072799 | - |
dc.identifier.hkuros | 286582 | - |
dc.identifier.volume | 36 | - |
dc.identifier.issue | 29 | - |
dc.identifier.spage | 4198 | - |
dc.identifier.epage | 4206 | - |
dc.identifier.isi | WOS:000437997300007 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0264-410X | - |