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- Publisher Website: 10.1007/s00330-018-5671-0
- Scopus: eid_2-s2.0-85051865769
- PMID: 30088067
- WOS: WOS:000457396100044
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Article: Role of second high-intensity focused ultrasound (HIFU) treatment for unsatisfactory benign thyroid nodules after first treatment
Title | Role of second high-intensity focused ultrasound (HIFU) treatment for unsatisfactory benign thyroid nodules after first treatment |
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Authors | |
Keywords | Ablation techniques High-intensity focused ultrasound ablation Interventional ultrasonography Treatment efficacy Ultrasound imaging |
Issue Date | 2018 |
Publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00330/index.htm |
Citation | European Radiology, 2018 How to Cite? |
Abstract | BACKGROUND:
We aimed to assess the efficacy and safety of second high-intensity focused ultrasound (HIFU) ablation treatment in benign thyroid nodules that had failed to shrink by > 50% 6 months after the first treatment.
METHODS:
Twenty-eight patients who did not achieve 50% volume reduction at 6 months after the first HIFU treatment underwent a second HIFU treatment. Nodule volume was measured on ultrasound at baseline, 3 months and 6 months. Extent of nodule shrinkage (by volume reduction ratio) (VRR) = [Baseline volume - volume at 6 months]/[Baseline volume] * 100. Treatment success was defined as VRR > 50%. Obstructive symptom score (by 0-10 visual analogue scale, VAS) was evaluated for 6 months after treatment.
RESULTS:
No complications occurred after the second treatment. The mean 6-month VRR was 21.78 ± 16.87% with a median (range) of 16.16 (1.63-54.07)%. At 6 months, only two (7.1%) patients achieved treatment success, while nine (32.1%) patients had VRR < 10%. However, relative to baseline (3.96 ± 1.04), the mean VAS significantly improved at 3 and 6 months (2.96 ± 1.43, p<0.001 and 2.58 ± 1.39, p<0.001, respectively). There was a significant correlation between VRR and improvement in VAS score at 6 months (ρ=0.438, p=0.025). Greater nodule volume before the second treatment (OR=1.169, 95% CI=1.004-1.361, p=0.045) was a significant factor for greater VRR after the second treatment.
CONCLUSIONS:
Although subjective obstructive symptoms continued to improve after the second treatment, the actual extent of nodule shrinkage was small. Larger-volume nodules tended to shrink more significantly than smaller-volume nodules in the second treatment.
KEY POINTS:
• Second treatment resulted in small shrinkage in unsatisfactory nodules after first treatment. • Obstructive symptoms tended to continue to improve after second treatment. • Larger-size nodules tended to respond better in the second treatment. |
Persistent Identifier | http://hdl.handle.net/10722/259237 |
ISSN | 2023 Impact Factor: 4.7 2023 SCImago Journal Rankings: 1.656 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lang, HHB | - |
dc.contributor.author | Woo, YC | - |
dc.contributor.author | Chiu, WHK | - |
dc.date.accessioned | 2018-09-03T04:03:41Z | - |
dc.date.available | 2018-09-03T04:03:41Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | European Radiology, 2018 | - |
dc.identifier.issn | 0938-7994 | - |
dc.identifier.uri | http://hdl.handle.net/10722/259237 | - |
dc.description.abstract | BACKGROUND: We aimed to assess the efficacy and safety of second high-intensity focused ultrasound (HIFU) ablation treatment in benign thyroid nodules that had failed to shrink by > 50% 6 months after the first treatment. METHODS: Twenty-eight patients who did not achieve 50% volume reduction at 6 months after the first HIFU treatment underwent a second HIFU treatment. Nodule volume was measured on ultrasound at baseline, 3 months and 6 months. Extent of nodule shrinkage (by volume reduction ratio) (VRR) = [Baseline volume - volume at 6 months]/[Baseline volume] * 100. Treatment success was defined as VRR > 50%. Obstructive symptom score (by 0-10 visual analogue scale, VAS) was evaluated for 6 months after treatment. RESULTS: No complications occurred after the second treatment. The mean 6-month VRR was 21.78 ± 16.87% with a median (range) of 16.16 (1.63-54.07)%. At 6 months, only two (7.1%) patients achieved treatment success, while nine (32.1%) patients had VRR < 10%. However, relative to baseline (3.96 ± 1.04), the mean VAS significantly improved at 3 and 6 months (2.96 ± 1.43, p<0.001 and 2.58 ± 1.39, p<0.001, respectively). There was a significant correlation between VRR and improvement in VAS score at 6 months (ρ=0.438, p=0.025). Greater nodule volume before the second treatment (OR=1.169, 95% CI=1.004-1.361, p=0.045) was a significant factor for greater VRR after the second treatment. CONCLUSIONS: Although subjective obstructive symptoms continued to improve after the second treatment, the actual extent of nodule shrinkage was small. Larger-volume nodules tended to shrink more significantly than smaller-volume nodules in the second treatment. KEY POINTS: • Second treatment resulted in small shrinkage in unsatisfactory nodules after first treatment. • Obstructive symptoms tended to continue to improve after second treatment. • Larger-size nodules tended to respond better in the second treatment. | - |
dc.language | eng | - |
dc.publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00330/index.htm | - |
dc.relation.ispartof | European Radiology | - |
dc.rights | The final publication is available at Springer via http://dx.doi.org/[insert DOI] | - |
dc.subject | Ablation techniques | - |
dc.subject | High-intensity focused ultrasound ablation | - |
dc.subject | Interventional ultrasonography | - |
dc.subject | Treatment efficacy | - |
dc.subject | Ultrasound imaging | - |
dc.title | Role of second high-intensity focused ultrasound (HIFU) treatment for unsatisfactory benign thyroid nodules after first treatment | - |
dc.type | Article | - |
dc.identifier.email | Lang, HHB: Blang@hku.hk | - |
dc.identifier.email | Woo, YC: wooyucho@hku.hk | - |
dc.identifier.email | Chiu, WHK: kwhchiu@hku.hk | - |
dc.identifier.authority | Lang, HHB=rp01828 | - |
dc.identifier.authority | Chiu, WHK=rp02074 | - |
dc.identifier.doi | 10.1007/s00330-018-5671-0 | - |
dc.identifier.pmid | 30088067 | - |
dc.identifier.scopus | eid_2-s2.0-85051865769 | - |
dc.identifier.hkuros | 289588 | - |
dc.identifier.volume | epub ahead of print | - |
dc.identifier.isi | WOS:000457396100044 | - |
dc.publisher.place | Germany | - |
dc.identifier.issnl | 0938-7994 | - |