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Article: Beta oscillations in major depression – signalling a new cortical circuit for central executive function

TitleBeta oscillations in major depression – signalling a new cortical circuit for central executive function
Authors
Issue Date2017
PublisherNature Publishing Group: Open Access Journals - Option C. The Journal's web site is located at http://www.nature.com/srep/index.html
Citation
Scientific Reports, 2017, v. 7, p. 18021 How to Cite?
AbstractThis study aimed to examine alterations in electroencephalography (EEG) phase synchronization in working memory processing in depressed patients. Sixty-four-channel EEG signals were recorded from 33 depressed patients and 32 healthy controls during a visual n-back task. Alterations in functional connections in the patients were investigated using event-related phase coherence in terms of the phase synchronization index (PSI). Compared with the control subjects, the depressed patients showed a lower task-dependent increase in the PSI of delta, theta, and alpha oscillations in a frontoparietal network, but a higher task-dependent increase in the PSI of beta oscillations in the frontoparietal network. Additionally, depressed patients showed a lower task-dependent decrease in the PSI of delta, theta, alpha, and beta oscillations in centro-parieto-occipital sites. Insufficient phase synchronization and desynchronization during working memory processing reflects impairments in cortical inhibition, memory, and attention efficiency in major depression, while the abnormal increase in phase synchronization in beta oscillations in the frontoparietal network may indicate a new cortical circuit concerned with the repair of impaired ability in attention, memory retention, and working memory central executive processing. These findings present a compensatory mechanism for impaired cognitive function in major depression, and advance our understanding of functional aspect of beta oscillations.
Persistent Identifierhttp://hdl.handle.net/10722/259419
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 0.900
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Y-
dc.contributor.authorKang, C-
dc.contributor.authorWei, Z-
dc.contributor.authorQu, X-
dc.contributor.authorLiu, T-
dc.contributor.authorZhou, Y-
dc.contributor.authorHu, Y-
dc.date.accessioned2018-09-03T04:07:08Z-
dc.date.available2018-09-03T04:07:08Z-
dc.date.issued2017-
dc.identifier.citationScientific Reports, 2017, v. 7, p. 18021-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10722/259419-
dc.description.abstractThis study aimed to examine alterations in electroencephalography (EEG) phase synchronization in working memory processing in depressed patients. Sixty-four-channel EEG signals were recorded from 33 depressed patients and 32 healthy controls during a visual n-back task. Alterations in functional connections in the patients were investigated using event-related phase coherence in terms of the phase synchronization index (PSI). Compared with the control subjects, the depressed patients showed a lower task-dependent increase in the PSI of delta, theta, and alpha oscillations in a frontoparietal network, but a higher task-dependent increase in the PSI of beta oscillations in the frontoparietal network. Additionally, depressed patients showed a lower task-dependent decrease in the PSI of delta, theta, alpha, and beta oscillations in centro-parieto-occipital sites. Insufficient phase synchronization and desynchronization during working memory processing reflects impairments in cortical inhibition, memory, and attention efficiency in major depression, while the abnormal increase in phase synchronization in beta oscillations in the frontoparietal network may indicate a new cortical circuit concerned with the repair of impaired ability in attention, memory retention, and working memory central executive processing. These findings present a compensatory mechanism for impaired cognitive function in major depression, and advance our understanding of functional aspect of beta oscillations.-
dc.languageeng-
dc.publisherNature Publishing Group: Open Access Journals - Option C. The Journal's web site is located at http://www.nature.com/srep/index.html-
dc.relation.ispartofScientific Reports-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleBeta oscillations in major depression – signalling a new cortical circuit for central executive function-
dc.typeArticle-
dc.identifier.emailHu, Y: yhud@hku.hk-
dc.identifier.authorityHu, Y=rp00432-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41598-017-18306-w-
dc.identifier.scopuseid_2-s2.0-85038965778-
dc.identifier.hkuros289687-
dc.identifier.volume7-
dc.identifier.spage18021-
dc.identifier.epage18021-
dc.identifier.isiWOS:000418562100061-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl2045-2322-

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