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Article: Clinicopathologic study of forty-four histologically pure supratentorial oligodendrogliomas

TitleClinicopathologic study of forty-four histologically pure supratentorial oligodendrogliomas
Authors
KeywordsAnaplastic oligodendroglioma
p53
Oligodendroglioma
MIB-1
Glioma
Issue Date2000
Citation
Annals of Diagnostic Pathology, 2000, v. 4, n. 4, p. 218-227 How to Cite?
AbstractFew studies in recent years have specifically focused on pure oligodendroglial neoplasms. We retrospectively reviewed the clinicopathologic features of 44 patients with supratentorial oligodendroglioma diagnosed over a 19-year period (1974 to 1993). The study group consisted of 44 patients (age range, 8 to 69 years; median, 42 years), including 31 males. Thirty-one initially resected tumors (70%) were low grade and 13 (30%) were high grade (anaplastic). Using the St Anne-Mayo criteria for astrocytic tumors, 19 tumors (43%) were grade 2, 17 (39%) were grade 3, and 8 were (18%) grade 4. Histologic features of the tumors at initial resection included prominent nucleoli (N = 18, 41%), vascular proliferation (N = 9, 20%), necrosis (N = 6, 14%), and microcystic degeneration (N = 23, 52%). Nuclear atypia was graded as mild in 22 tumors (50%), moderate in 18 (41%), and marked in four (9%). The highest mitosis counts ranged from 0 to 10 mitotic figures (MF)/10 high-power fields (HPF) (mean, 2.4). Twelve patients (27%) had four or more MF/10 HPF. Initial surgery included gross total resection in 10 patients, subtotal resection in 16 patients, and biopsy in 14 patients. Thirty-one patients received adjuvant radiotherapy and 15 received chemotherapy. MIB-1 labeling indices ranged from 0 to 42.3 (median, 1.2 [low grade tumor median, 0.5; anaplastic tumor median, 6.2]). p53 immunostaining was observed in 18 of 43 stained tumors (41%). Overall, 5- and 10-year survival rates were 71% and 63%, respectively. The entire group had a median follow-up of 5.2 years. Age greater than 45 years (P = .02), mitosis counts of ≥4 MF/10 HPF (P = .0004), and MIB-1 labeling indices <2 (P = .03) were independent predictors of survival (Kaplan-Meier analysis). MIB-1 labeling indices <2 (P = .0009) was an independent predictor of disease-free survival. Low cell density (P = .04) and low histologic grade (P = .03) show trends with regard to being associated with longer survival. In conclusion, older patients (>45 years) or patients with tumors with an increased rate of cell proliferation generally have a worse prognosis. Although tumors of high histologic grade generally have a worse survival, the correlation was not statistically significant. Copyright (C) 2000 by W.B. Saunders Company.
Persistent Identifierhttp://hdl.handle.net/10722/260268
ISSN
2023 Impact Factor: 1.5
2023 SCImago Journal Rankings: 0.575

 

DC FieldValueLanguage
dc.contributor.authorPrayson, Richard A.-
dc.contributor.authorMohan, Dasarahally S.-
dc.contributor.authorSong, Priscilla-
dc.contributor.authorSuh, John H.-
dc.date.accessioned2018-09-12T02:00:57Z-
dc.date.available2018-09-12T02:00:57Z-
dc.date.issued2000-
dc.identifier.citationAnnals of Diagnostic Pathology, 2000, v. 4, n. 4, p. 218-227-
dc.identifier.issn1092-9134-
dc.identifier.urihttp://hdl.handle.net/10722/260268-
dc.description.abstractFew studies in recent years have specifically focused on pure oligodendroglial neoplasms. We retrospectively reviewed the clinicopathologic features of 44 patients with supratentorial oligodendroglioma diagnosed over a 19-year period (1974 to 1993). The study group consisted of 44 patients (age range, 8 to 69 years; median, 42 years), including 31 males. Thirty-one initially resected tumors (70%) were low grade and 13 (30%) were high grade (anaplastic). Using the St Anne-Mayo criteria for astrocytic tumors, 19 tumors (43%) were grade 2, 17 (39%) were grade 3, and 8 were (18%) grade 4. Histologic features of the tumors at initial resection included prominent nucleoli (N = 18, 41%), vascular proliferation (N = 9, 20%), necrosis (N = 6, 14%), and microcystic degeneration (N = 23, 52%). Nuclear atypia was graded as mild in 22 tumors (50%), moderate in 18 (41%), and marked in four (9%). The highest mitosis counts ranged from 0 to 10 mitotic figures (MF)/10 high-power fields (HPF) (mean, 2.4). Twelve patients (27%) had four or more MF/10 HPF. Initial surgery included gross total resection in 10 patients, subtotal resection in 16 patients, and biopsy in 14 patients. Thirty-one patients received adjuvant radiotherapy and 15 received chemotherapy. MIB-1 labeling indices ranged from 0 to 42.3 (median, 1.2 [low grade tumor median, 0.5; anaplastic tumor median, 6.2]). p53 immunostaining was observed in 18 of 43 stained tumors (41%). Overall, 5- and 10-year survival rates were 71% and 63%, respectively. The entire group had a median follow-up of 5.2 years. Age greater than 45 years (P = .02), mitosis counts of ≥4 MF/10 HPF (P = .0004), and MIB-1 labeling indices <2 (P = .03) were independent predictors of survival (Kaplan-Meier analysis). MIB-1 labeling indices <2 (P = .0009) was an independent predictor of disease-free survival. Low cell density (P = .04) and low histologic grade (P = .03) show trends with regard to being associated with longer survival. In conclusion, older patients (>45 years) or patients with tumors with an increased rate of cell proliferation generally have a worse prognosis. Although tumors of high histologic grade generally have a worse survival, the correlation was not statistically significant. Copyright (C) 2000 by W.B. Saunders Company.-
dc.languageeng-
dc.relation.ispartofAnnals of Diagnostic Pathology-
dc.subjectAnaplastic oligodendroglioma-
dc.subjectp53-
dc.subjectOligodendroglioma-
dc.subjectMIB-1-
dc.subjectGlioma-
dc.titleClinicopathologic study of forty-four histologically pure supratentorial oligodendrogliomas-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1053/adpa.2000.8124-
dc.identifier.pmid10982299-
dc.identifier.scopuseid_2-s2.0-0033624663-
dc.identifier.volume4-
dc.identifier.issue4-
dc.identifier.spage218-
dc.identifier.epage227-
dc.identifier.issnl1092-9134-

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