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Conference Paper: Effect of different surgical procedures on bone healing in rabbit model treated with zoledronic acid

TitleEffect of different surgical procedures on bone healing in rabbit model treated with zoledronic acid
Authors
Issue Date2017
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/ijom
Citation
23rd International Conference on Oral & Maxillofacial Surgery, Hong Kong, 31 March - 3 April 2017. In International Journal of Oral and Maxillofacial Surgery, 2017, v. 46 n. Suppl. 1, p. 220-221 How to Cite?
AbstractBackground: Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious complication of various drugs including bisphosphonates, denosumab, and antiangiogenic agents. Surgical intervention is known as a risk factor for MRONJ, however, the etiopathogenesis remains unclear. Whether different surgical procedures have different effects on bone healing needs further investigation. Objectives: To compare the risk of different surgical procedures of mandibular tooth extraction in inducing MRONJ. Methods: Twenty New Zealand White (NZW) rabbits received subcutaneous (s/c) injections of zoledronic acid (ZA; n = 10) or saline vehicle (n = 10) for four weeks until teeth extraction. The extraction was performed on the first premolar on both sides of mandible, the socket on one side was closed by sutures and the other side was left open. Rabbits then continued to receive zoledronic acid or saline till sacrifice at week four and week eight. After tooth extraction, rabbits were injected (s/c) with fluorochrome labeling solutions. The extraction sites were collected for microcomputed tomography and histomorphometric analysis. Findings and Conclusion: Thinner periodontal ligament space and higher bone mineral density were found in ZA treated group. More data are still under analysis.
Description4G Free Paper Session – Research / Technology 4 - no. OR527
Persistent Identifierhttp://hdl.handle.net/10722/260349
ISSN
2019 Impact Factor: 2.068
2015 SCImago Journal Rankings: 0.854

 

DC FieldValueLanguage
dc.contributor.authorYu, RQ-
dc.contributor.authorZheng, L-
dc.date.accessioned2018-09-14T08:40:14Z-
dc.date.available2018-09-14T08:40:14Z-
dc.date.issued2017-
dc.identifier.citation23rd International Conference on Oral & Maxillofacial Surgery, Hong Kong, 31 March - 3 April 2017. In International Journal of Oral and Maxillofacial Surgery, 2017, v. 46 n. Suppl. 1, p. 220-221-
dc.identifier.issn0901-5027-
dc.identifier.urihttp://hdl.handle.net/10722/260349-
dc.description4G Free Paper Session – Research / Technology 4 - no. OR527-
dc.description.abstractBackground: Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious complication of various drugs including bisphosphonates, denosumab, and antiangiogenic agents. Surgical intervention is known as a risk factor for MRONJ, however, the etiopathogenesis remains unclear. Whether different surgical procedures have different effects on bone healing needs further investigation. Objectives: To compare the risk of different surgical procedures of mandibular tooth extraction in inducing MRONJ. Methods: Twenty New Zealand White (NZW) rabbits received subcutaneous (s/c) injections of zoledronic acid (ZA; n = 10) or saline vehicle (n = 10) for four weeks until teeth extraction. The extraction was performed on the first premolar on both sides of mandible, the socket on one side was closed by sutures and the other side was left open. Rabbits then continued to receive zoledronic acid or saline till sacrifice at week four and week eight. After tooth extraction, rabbits were injected (s/c) with fluorochrome labeling solutions. The extraction sites were collected for microcomputed tomography and histomorphometric analysis. Findings and Conclusion: Thinner periodontal ligament space and higher bone mineral density were found in ZA treated group. More data are still under analysis.-
dc.languageeng-
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/ijom-
dc.relation.ispartofInternational Journal of Oral and Maxillofacial Surgery-
dc.relation.ispartof23rd International Conference on Oral & Maxillofacial Surgery (ICOMS 2017)-
dc.titleEffect of different surgical procedures on bone healing in rabbit model treated with zoledronic acid-
dc.typeConference_Paper-
dc.identifier.emailZheng, L: lwzheng@hkucc.hku.hk-
dc.identifier.authorityZheng, L=rp01411-
dc.identifier.doi10.1016/j.ijom.2017.02.746-
dc.identifier.hkuros290395-
dc.identifier.volume46-
dc.identifier.issueSuppl. 1-
dc.identifier.spage220-
dc.identifier.epage221-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl0901-5027-

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