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Article: Distribution and Functional Implication of Secretin in Multiple Brain Regions
Title | Distribution and Functional Implication of Secretin in Multiple Brain Regions |
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Authors | |
Keywords | Anxiety Drug target Food and water intake Motor learning Secretin Stress Transgenic mice |
Issue Date | 2019 |
Publisher | Humana Press, Inc. The Journal's web site is located at http://www.springer.com/humana+press/neuroscience/journal/12031 |
Citation | Journal of Molecular Neuroscience, 2019, v. 68 n. 3, p. 485–493 How to Cite? |
Abstract | Secretin is a polypeptide hormone initially identified for its gastrointestinal functions. However, emerging evidences show wide distribution of secretin and secretin receptor across various brain regions from cerebral cortex, hippocampus, hypothalamus to cerebellum. In this mini review, we will firstly describe the region-specific expression pattern of secretin and secretin receptor in the brain, followed by a summary of central physiological and neurological functions mediated by secretin. Using genetic manipulation and pharmaceutical approaches, one can elucidate the role of secretin in mediating various neurological functions from simple behaviors, such as water and food intake, to more complex functions including emotion, motor, and learning or memory. At last, current weakness and future perspectives of secretin in the central nervous system will be discussed, aiming to provide the potency of using secretin or its analog for treating various neurological disorders. |
Persistent Identifier | http://hdl.handle.net/10722/260874 |
ISSN | 2023 Impact Factor: 2.8 2023 SCImago Journal Rankings: 0.747 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wang, R | - |
dc.contributor.author | Chow, BKC | - |
dc.contributor.author | Zhang, L | - |
dc.date.accessioned | 2018-09-14T08:48:49Z | - |
dc.date.available | 2018-09-14T08:48:49Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Journal of Molecular Neuroscience, 2019, v. 68 n. 3, p. 485–493 | - |
dc.identifier.issn | 0895-8696 | - |
dc.identifier.uri | http://hdl.handle.net/10722/260874 | - |
dc.description.abstract | Secretin is a polypeptide hormone initially identified for its gastrointestinal functions. However, emerging evidences show wide distribution of secretin and secretin receptor across various brain regions from cerebral cortex, hippocampus, hypothalamus to cerebellum. In this mini review, we will firstly describe the region-specific expression pattern of secretin and secretin receptor in the brain, followed by a summary of central physiological and neurological functions mediated by secretin. Using genetic manipulation and pharmaceutical approaches, one can elucidate the role of secretin in mediating various neurological functions from simple behaviors, such as water and food intake, to more complex functions including emotion, motor, and learning or memory. At last, current weakness and future perspectives of secretin in the central nervous system will be discussed, aiming to provide the potency of using secretin or its analog for treating various neurological disorders. | - |
dc.language | eng | - |
dc.publisher | Humana Press, Inc. The Journal's web site is located at http://www.springer.com/humana+press/neuroscience/journal/12031 | - |
dc.relation.ispartof | Journal of Molecular Neuroscience | - |
dc.rights | The final publication is available at Springer via http://dx.doi.org/10.1007/s12031-018-1089-z | - |
dc.subject | Anxiety | - |
dc.subject | Drug target | - |
dc.subject | Food and water intake | - |
dc.subject | Motor learning | - |
dc.subject | Secretin | - |
dc.subject | Stress | - |
dc.subject | Transgenic mice | - |
dc.title | Distribution and Functional Implication of Secretin in Multiple Brain Regions | - |
dc.type | Article | - |
dc.identifier.email | Chow, BKC: bkcc@hku.hk | - |
dc.identifier.authority | Chow, BKC=rp00681 | - |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1007/s12031-018-1089-z | - |
dc.identifier.scopus | eid_2-s2.0-85048086721 | - |
dc.identifier.hkuros | 291532 | - |
dc.identifier.volume | 68 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 485 | - |
dc.identifier.epage | 493 | - |
dc.identifier.isi | WOS:000472082700017 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0895-8696 | - |