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Article: Secretin Modulates the Postnatal Development of Mouse Cerebellar Cortex Via PKA- and ERK-dependent Pathways
Title | Secretin Modulates the Postnatal Development of Mouse Cerebellar Cortex Via PKA- and ERK-dependent Pathways |
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Authors | |
Keywords | Cell apoptosis Cerebellar development ERK1/2 Granular cell migration PKA Purkinje cell morphogenesis Secretin |
Issue Date | 2017 |
Publisher | Frontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/cellular_neuroscience |
Citation | Frontiers in Cellular Neuroscience, 2017, v. 11, p. 382 How to Cite? |
Abstract | Postnatal development of the cerebellum is critical for its intact function such as motor coordination and has been implicated in the pathogenesis of psychiatric disorders. We previously reported that deprivation of secretin (SCT) from cerebellar Purkinje neurons impaired motor coordination and motor learning function, while leaving the potential role of SCT in cerebellar development to be determined. SCT and its receptor (SCTR) were constitutively expressed in the postnatal cerebellum in a temporal and cell-specific manner. Using a SCT knockout mouse model, we provided direct evidence showing altered developmental patterns of Purkinje cells (PCs) and granular cells (GCs). SCT deprivation reduced the PC density, impaired the PC dendritic formation, induced accelerated GC migration and potentiated cerebellar apoptosis. Furthermore, our results indicated the involvement of protein kinase A (PKA) and extracellular signal regulated kinase (ERK) signaling pathways in SCT-mediated protective effects against neuronal apoptosis. Results of this study illustrated a novel function of SCT in the postnatal development of cerebellum, emphasizing the necessary role of SCT in cerebellar-related functions. |
Persistent Identifier | http://hdl.handle.net/10722/260875 |
ISSN | 2023 Impact Factor: 4.2 2023 SCImago Journal Rankings: 1.471 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | WANG, L | - |
dc.contributor.author | Zhang, L | - |
dc.contributor.author | Chow, BKC | - |
dc.date.accessioned | 2018-09-14T08:48:50Z | - |
dc.date.available | 2018-09-14T08:48:50Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Frontiers in Cellular Neuroscience, 2017, v. 11, p. 382 | - |
dc.identifier.issn | 1662-5102 | - |
dc.identifier.uri | http://hdl.handle.net/10722/260875 | - |
dc.description.abstract | Postnatal development of the cerebellum is critical for its intact function such as motor coordination and has been implicated in the pathogenesis of psychiatric disorders. We previously reported that deprivation of secretin (SCT) from cerebellar Purkinje neurons impaired motor coordination and motor learning function, while leaving the potential role of SCT in cerebellar development to be determined. SCT and its receptor (SCTR) were constitutively expressed in the postnatal cerebellum in a temporal and cell-specific manner. Using a SCT knockout mouse model, we provided direct evidence showing altered developmental patterns of Purkinje cells (PCs) and granular cells (GCs). SCT deprivation reduced the PC density, impaired the PC dendritic formation, induced accelerated GC migration and potentiated cerebellar apoptosis. Furthermore, our results indicated the involvement of protein kinase A (PKA) and extracellular signal regulated kinase (ERK) signaling pathways in SCT-mediated protective effects against neuronal apoptosis. Results of this study illustrated a novel function of SCT in the postnatal development of cerebellum, emphasizing the necessary role of SCT in cerebellar-related functions. | - |
dc.language | eng | - |
dc.publisher | Frontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/cellular_neuroscience | - |
dc.relation.ispartof | Frontiers in Cellular Neuroscience | - |
dc.rights | This Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Cell apoptosis | - |
dc.subject | Cerebellar development | - |
dc.subject | ERK1/2 | - |
dc.subject | Granular cell migration | - |
dc.subject | PKA | - |
dc.subject | Purkinje cell morphogenesis | - |
dc.subject | Secretin | - |
dc.title | Secretin Modulates the Postnatal Development of Mouse Cerebellar Cortex Via PKA- and ERK-dependent Pathways | - |
dc.type | Article | - |
dc.identifier.email | Chow, BKC: bkcc@hku.hk | - |
dc.identifier.authority | Chow, BKC=rp00681 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3389/fncel.2017.00382 | - |
dc.identifier.scopus | eid_2-s2.0-85040928296 | - |
dc.identifier.hkuros | 291535 | - |
dc.identifier.volume | 11 | - |
dc.identifier.spage | 382 | - |
dc.identifier.epage | 382 | - |
dc.identifier.isi | WOS:000416541900001 | - |
dc.publisher.place | Switzerland | - |
dc.identifier.issnl | 1662-5102 | - |