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Conference Paper: Secretin deficiency causes cardiopulmonary pathologies in mice
| Title | Secretin deficiency causes cardiopulmonary pathologies in mice |
|---|---|
| Authors | |
| Issue Date | 2017 |
| Citation | 13th International Symposium on VIP, PACAP and Related Peptides: Bioactive peptides in novel translational developments and therapeutic implications, Hong Kong SAR, China, 3-7 December 2017 How to Cite? |
| Abstract | tract and short-term cardiovascular effects. However, the effect of SCT deficiency in the cardiopulmonary system has not studied yet and we investigated using male 6-month-old secretin knockout (SCT-/-) mice and age-matched C57BL/6N mice. We observed that SCT-/- mice have increased pulmonary arterial pressure [30.37±1.65 vs. 58.42±6.83 mmHg, p=0.0031] and systemic arterial pressure [Systolic Blood Pressure: 138.91±7.36 vs. 117.42±2.96 mmHg, p=0.0283]. Perivascular inflammation, edema formation and bronchiolar epithelium depletion were observed in the lungs. In the heart, apoptosis and fibrosis were detected. We also found that serum nitric oxide (NO) and vascular endothelial growth factor (VEGF) levels were reduced and excess plasma aldosterone levels in SCT-/- mice. After the 3-month-long SCT replacement, the cardiopulmonary pathologies were reduced. Our study showed that the cardiopulmonary pathologies in SCT-/- mice could be associated with NO, VEGF and aldosterone related mechanisms. |
| Description | Oral Communication 1 |
| Persistent Identifier | http://hdl.handle.net/10722/262113 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Zaw, AM | - |
| dc.contributor.author | Law, HK | - |
| dc.contributor.author | Chow, BKC | - |
| dc.date.accessioned | 2018-09-28T04:53:31Z | - |
| dc.date.available | 2018-09-28T04:53:31Z | - |
| dc.date.issued | 2017 | - |
| dc.identifier.citation | 13th International Symposium on VIP, PACAP and Related Peptides: Bioactive peptides in novel translational developments and therapeutic implications, Hong Kong SAR, China, 3-7 December 2017 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/262113 | - |
| dc.description | Oral Communication 1 | - |
| dc.description.abstract | tract and short-term cardiovascular effects. However, the effect of SCT deficiency in the cardiopulmonary system has not studied yet and we investigated using male 6-month-old secretin knockout (SCT-/-) mice and age-matched C57BL/6N mice. We observed that SCT-/- mice have increased pulmonary arterial pressure [30.37±1.65 vs. 58.42±6.83 mmHg, p=0.0031] and systemic arterial pressure [Systolic Blood Pressure: 138.91±7.36 vs. 117.42±2.96 mmHg, p=0.0283]. Perivascular inflammation, edema formation and bronchiolar epithelium depletion were observed in the lungs. In the heart, apoptosis and fibrosis were detected. We also found that serum nitric oxide (NO) and vascular endothelial growth factor (VEGF) levels were reduced and excess plasma aldosterone levels in SCT-/- mice. After the 3-month-long SCT replacement, the cardiopulmonary pathologies were reduced. Our study showed that the cardiopulmonary pathologies in SCT-/- mice could be associated with NO, VEGF and aldosterone related mechanisms. | - |
| dc.language | eng | - |
| dc.relation.ispartof | 13th International Symposium on VIP, PACAP and Related Peptides | - |
| dc.title | Secretin deficiency causes cardiopulmonary pathologies in mice | - |
| dc.type | Conference_Paper | - |
| dc.identifier.email | Chow, BKC: bkcc@hku.hk | - |
| dc.identifier.authority | Chow, BKC=rp00681 | - |
| dc.identifier.hkuros | 292957 | - |