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Article: Down‐regulation of TROP‐2 Predicts Poor Prognosis of Hepatocellular Carcinoma Patients
Title | Down‐regulation of TROP‐2 Predicts Poor Prognosis of Hepatocellular Carcinoma Patients |
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Authors | |
Issue Date | 2018 |
Publisher | John Wiley & Sons Ltd.. The Journal's web site is located at http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)2471-254X/ |
Citation | Hepatology Communications, 2018, v. 2 n. 11, p. 1408-1414 How to Cite? |
Abstract | Hepatocellular carcinoma (HCC) is one of the most common and lethal cancer types worldwide, especially in Asian countries. Genetic alterations, including hyperactivation of oncogenes and loss of expression of tumor suppressor genes, greatly contribute to the initiation and progression of HCC. Here we report that down‐regulation of trophoblast cell surface antigen 2 (TROP‐2) was frequently detected in HCC. Transcriptome sequencing of non‐tumor and HCC patient samples revealed down‐regulation of TROP‐2 in tumor tissues. Immunohistochemical staining showed nearly undetectable levels of TROP‐2 in HCC tissues but distinct and strong staining of TROP‐2 in adjacent non‐tumor tissues. The frequent down‐regulation of TROP‐2 expression was further confirmed in an in‐house cohort of 205 pairs of HCC patient samples and in the Cancer Genome Atlas (TCGA) databases. Furthermore, the down‐regulation of TROP‐2 was associated with poor overall survival of HCC patients, severe adjacent organ invasion, and poor differentiation of HCC. Using bisulfite genomic sequencing and methylation‐specific polymerase chain reaction analyses, we show that higher levels of promoter methylation were detected in the DNA samples of HCC tissues (low TROP‐2 expression) than that of the non‐tumor tissues (high TROP‐2 expression). Conclusion: Taken together, our data suggest that promoter hypermethylation contributes to the frequent down‐regulation of TROP‐2 in HCC, and that TROP‐2 down‐regulation predicts poor prognosis of HCC patients. |
Persistent Identifier | http://hdl.handle.net/10722/262278 |
ISSN | 2023 Impact Factor: 5.6 2023 SCImago Journal Rankings: 2.217 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Sin, ST | - |
dc.contributor.author | Li, Y | - |
dc.contributor.author | Liu, M | - |
dc.contributor.author | Yuan, YF | - |
dc.contributor.author | Ma, SKY | - |
dc.contributor.author | Guan, X | - |
dc.date.accessioned | 2018-09-28T04:56:30Z | - |
dc.date.available | 2018-09-28T04:56:30Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Hepatology Communications, 2018, v. 2 n. 11, p. 1408-1414 | - |
dc.identifier.issn | 2471-254X | - |
dc.identifier.uri | http://hdl.handle.net/10722/262278 | - |
dc.description.abstract | Hepatocellular carcinoma (HCC) is one of the most common and lethal cancer types worldwide, especially in Asian countries. Genetic alterations, including hyperactivation of oncogenes and loss of expression of tumor suppressor genes, greatly contribute to the initiation and progression of HCC. Here we report that down‐regulation of trophoblast cell surface antigen 2 (TROP‐2) was frequently detected in HCC. Transcriptome sequencing of non‐tumor and HCC patient samples revealed down‐regulation of TROP‐2 in tumor tissues. Immunohistochemical staining showed nearly undetectable levels of TROP‐2 in HCC tissues but distinct and strong staining of TROP‐2 in adjacent non‐tumor tissues. The frequent down‐regulation of TROP‐2 expression was further confirmed in an in‐house cohort of 205 pairs of HCC patient samples and in the Cancer Genome Atlas (TCGA) databases. Furthermore, the down‐regulation of TROP‐2 was associated with poor overall survival of HCC patients, severe adjacent organ invasion, and poor differentiation of HCC. Using bisulfite genomic sequencing and methylation‐specific polymerase chain reaction analyses, we show that higher levels of promoter methylation were detected in the DNA samples of HCC tissues (low TROP‐2 expression) than that of the non‐tumor tissues (high TROP‐2 expression). Conclusion: Taken together, our data suggest that promoter hypermethylation contributes to the frequent down‐regulation of TROP‐2 in HCC, and that TROP‐2 down‐regulation predicts poor prognosis of HCC patients. | - |
dc.language | eng | - |
dc.publisher | John Wiley & Sons Ltd.. The Journal's web site is located at http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)2471-254X/ | - |
dc.relation.ispartof | Hepatology Communications | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Down‐regulation of TROP‐2 Predicts Poor Prognosis of Hepatocellular Carcinoma Patients | - |
dc.type | Article | - |
dc.identifier.email | Ma, SKY: stefma@hku.hk | - |
dc.identifier.email | Guan, X: xyguan@hku.hk | - |
dc.identifier.authority | Ma, SKY=rp00506 | - |
dc.identifier.authority | Guan, X=rp00454 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1002/hep4.1242 | - |
dc.identifier.scopus | eid_2-s2.0-85090771411 | - |
dc.identifier.hkuros | 292983 | - |
dc.identifier.volume | 2 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 1408 | - |
dc.identifier.epage | 1414 | - |
dc.identifier.isi | WOS:000452466300013 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 2471-254X | - |