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Book Chapter: Human T-Cell Leukemia Virus Type 1 Infection and Adult T-Cell Leukemia

TitleHuman T-Cell Leukemia Virus Type 1 Infection and Adult T-Cell Leukemia
Authors
KeywordsHuman T-cell leukemia virus type 1
Adult T-cell leukemia
Tax
HBZ
Humanized mouse model
Issue Date2017
PublisherSpringer Singapore.
Citation
Human T-Cell Leukemia Virus Type 1 Infection and Adult T-Cell Leukemia. In Cai, Q, Yuan, Z and Lan, K (Eds.), Infectious Agents Associated Cancers: Epidemiology and Molecular Biology, p. 147-166. Singapore: Springer Singapore, 2017 How to Cite?
AbstractHuman T-cell leukemia virus type 1 (HTLV-1) is the first retrovirus discovered to cause adult T-cell leukemia (ATL), a highly aggressive blood cancer. HTLV-1 research in the past 35 years has been most revealing in the mechanisms of viral oncogenesis. HTLV-1 establishes a lifelong persistent infection in CD4+ T lymphocytes. The infection outcome is governed by host immunity. ATL develops in 2–5% of infected individuals 30–50 years after initial exposure. HTLV-1 encodes two oncoproteins Tax and HBZ, which are required for initiation of cellular transformation and maintenance of cell proliferation, respectively. HTLV-1 oncogenesis is driven by a clonal selection and expansion process during which both host and viral factors cooperate to impair genome stability, immune surveillance, and other mechanisms of tumor suppression. A better understanding of HTLV-1 biology and leukemogenesis will reveal new strategies and modalities for ATL prevention and treatment.
Persistent Identifierhttp://hdl.handle.net/10722/262281
ISBN
ISSN
2021 Impact Factor: 3.650
2023 SCImago Journal Rankings: 0.244
ISI Accession Number ID
Series/Report no.Advances in Experimental Medicine and Biology; 1018

 

DC FieldValueLanguage
dc.contributor.authorChan, CP-
dc.contributor.authorKok, KH-
dc.contributor.authorJin, D-
dc.date.accessioned2018-09-28T04:56:36Z-
dc.date.available2018-09-28T04:56:36Z-
dc.date.issued2017-
dc.identifier.citationHuman T-Cell Leukemia Virus Type 1 Infection and Adult T-Cell Leukemia. In Cai, Q, Yuan, Z and Lan, K (Eds.), Infectious Agents Associated Cancers: Epidemiology and Molecular Biology, p. 147-166. Singapore: Springer Singapore, 2017-
dc.identifier.isbn9789811057649-
dc.identifier.issn0065-2598-
dc.identifier.urihttp://hdl.handle.net/10722/262281-
dc.description.abstractHuman T-cell leukemia virus type 1 (HTLV-1) is the first retrovirus discovered to cause adult T-cell leukemia (ATL), a highly aggressive blood cancer. HTLV-1 research in the past 35 years has been most revealing in the mechanisms of viral oncogenesis. HTLV-1 establishes a lifelong persistent infection in CD4+ T lymphocytes. The infection outcome is governed by host immunity. ATL develops in 2–5% of infected individuals 30–50 years after initial exposure. HTLV-1 encodes two oncoproteins Tax and HBZ, which are required for initiation of cellular transformation and maintenance of cell proliferation, respectively. HTLV-1 oncogenesis is driven by a clonal selection and expansion process during which both host and viral factors cooperate to impair genome stability, immune surveillance, and other mechanisms of tumor suppression. A better understanding of HTLV-1 biology and leukemogenesis will reveal new strategies and modalities for ATL prevention and treatment.-
dc.languageeng-
dc.publisherSpringer Singapore.-
dc.relation.ispartofInfectious Agents Associated Cancers: Epidemiology and Molecular Biology-
dc.relation.ispartofseriesAdvances in Experimental Medicine and Biology; 1018-
dc.subjectHuman T-cell leukemia virus type 1-
dc.subjectAdult T-cell leukemia-
dc.subjectTax-
dc.subjectHBZ-
dc.subjectHumanized mouse model-
dc.titleHuman T-Cell Leukemia Virus Type 1 Infection and Adult T-Cell Leukemia-
dc.typeBook_Chapter-
dc.identifier.emailChan, CP: chancp10@hku.hk-
dc.identifier.emailKok, KH: khkok@hku.hk-
dc.identifier.emailJin, D: dyjin@hku.hk-
dc.identifier.authorityChan, CP=rp02031-
dc.identifier.authorityKok, KH=rp01455-
dc.identifier.authorityJin, D=rp00452-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/978-981-10-5765-6_9-
dc.identifier.scopuseid_2-s2.0-85031997428-
dc.identifier.hkuros292026-
dc.identifier.spage147-
dc.identifier.epage166-
dc.identifier.eissn2214-8019-
dc.identifier.isiWOS:000759498800010-
dc.publisher.placeSingapore-
dc.identifier.issnl0065-2598-

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