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Article: Evaluation on improved tooth pulp electrical stimulation rat model

TitleEvaluation on improved tooth pulp electrical stimulation rat model
Authors
Issue Date2007
Citation
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2007, v. 25, n. 4, p. 404-407 How to Cite?
AbstractOBJECTIVE: To improve tooth pulp electrical stimulation rat model to study analgesic effect of drugs.METHODS: Expose lower mandible and incisor and isolate them with rubber dam, two holes with distance 1.5 mm were drilled below the cemento-enamel junction by a thin diamond bur in 22 adult male rats anesthetized with sodium pentobarbital. A pair of insulated stainless stimulating electrodes were inserted through the holes and knotted to fix them. Drilled holes were filled with zinc polycarboxylate cement. Finally, the stimulating electrodes were directed to the top of the skull. Pain threshold of rats was determined by an electrical stimulator under awake, free conditions to evaluate the stability of the model and the analgesic effect of drugs.RESULTS: A valid tooth pulp pain model were set up successfully in 22 rats. Rats regain consciousness at 1 to 2 hours after operation. The inserted electrodes keep efficiency for 6 weeks. Neither tissue morphology change nor inflammation cell infiltration can be found in tooth pulp after 6 weeks under the light microscope. Threshold voltages remained constant under the repeat electric stimulations within 300 min (P > 0.05, CV < 15%) until 4 weeks (P > 0.05, CV < 15%). The dose-dependent and time-dependent analgesic effects of capsaicin were showed in this model.CONCLUSION: The improved tooth pulp electrical stimulation rat model is easily performed and shows constant electrical stimulation-induced pain threshold and is suitable for research on analgesic effect of drugs.
Persistent Identifierhttp://hdl.handle.net/10722/262673
ISSN
2023 SCImago Journal Rankings: 0.177

 

DC FieldValueLanguage
dc.contributor.authorPeng, Si min-
dc.contributor.authorLing, Jun qi-
dc.date.accessioned2018-10-08T02:46:42Z-
dc.date.available2018-10-08T02:46:42Z-
dc.date.issued2007-
dc.identifier.citationHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2007, v. 25, n. 4, p. 404-407-
dc.identifier.issn1000-1182-
dc.identifier.urihttp://hdl.handle.net/10722/262673-
dc.description.abstractOBJECTIVE: To improve tooth pulp electrical stimulation rat model to study analgesic effect of drugs.METHODS: Expose lower mandible and incisor and isolate them with rubber dam, two holes with distance 1.5 mm were drilled below the cemento-enamel junction by a thin diamond bur in 22 adult male rats anesthetized with sodium pentobarbital. A pair of insulated stainless stimulating electrodes were inserted through the holes and knotted to fix them. Drilled holes were filled with zinc polycarboxylate cement. Finally, the stimulating electrodes were directed to the top of the skull. Pain threshold of rats was determined by an electrical stimulator under awake, free conditions to evaluate the stability of the model and the analgesic effect of drugs.RESULTS: A valid tooth pulp pain model were set up successfully in 22 rats. Rats regain consciousness at 1 to 2 hours after operation. The inserted electrodes keep efficiency for 6 weeks. Neither tissue morphology change nor inflammation cell infiltration can be found in tooth pulp after 6 weeks under the light microscope. Threshold voltages remained constant under the repeat electric stimulations within 300 min (P > 0.05, CV < 15%) until 4 weeks (P > 0.05, CV < 15%). The dose-dependent and time-dependent analgesic effects of capsaicin were showed in this model.CONCLUSION: The improved tooth pulp electrical stimulation rat model is easily performed and shows constant electrical stimulation-induced pain threshold and is suitable for research on analgesic effect of drugs.-
dc.languageeng-
dc.relation.ispartofHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology-
dc.titleEvaluation on improved tooth pulp electrical stimulation rat model-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid17896504-
dc.identifier.scopuseid_2-s2.0-84930398160-
dc.identifier.volume25-
dc.identifier.issue4-
dc.identifier.spage404-
dc.identifier.epage407-
dc.identifier.issnl1000-1182-

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