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Article: Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity
Title | Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity |
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Authors | |
Keywords | Sperm RNA Epigenetic inheritance Noncoding RNA Paternal effects |
Issue Date | 2016 |
Citation | Molecular Metabolism, 2016, v. 5, n. 8, p. 699-708 How to Cite? |
Abstract | © 2016 The Author(s) Objective Parental obesity can induce metabolic phenotypes in offspring independent of the inherited DNA sequence. Here we asked whether such non-genetic acquired metabolic traits can be passed on to a second generation that has never been exposed to obesity, even as germ cells. Methods We examined the F1, F2, and F3 a/a offspring derived from F0 matings of obese prediabetic Avy/a sires and lean a/a dams. After F0, only lean a/a mice were used for breeding. Results We found that F1 sons of obese founder males exhibited defects in glucose and lipid metabolism, but only upon a post-weaning dietary challenge. F1 males transmitted these defects to their own male progeny (F2) in the absence of the dietary challenge, but the phenotype was largely attenuated by F3. The sperm of F1 males exhibited changes in the abundance of several small RNA species, including the recently reported diet-responsive tRNA-derived fragments. Conclusions These data indicate that induced metabolic phenotypes may be propagated for a generation beyond any direct exposure to an inducing factor. This non-genetic inheritance likely occurs via the actions of sperm noncoding RNA. |
Persistent Identifier | http://hdl.handle.net/10722/262708 |
ISSN | 2023 Impact Factor: 7.0 2023 SCImago Journal Rankings: 3.034 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Cropley, Jennifer E. | - |
dc.contributor.author | Eaton, Sally A. | - |
dc.contributor.author | Aiken, Alastair | - |
dc.contributor.author | Young, Paul E. | - |
dc.contributor.author | Giannoulatou, Eleni | - |
dc.contributor.author | Ho, Joshua W.K. | - |
dc.contributor.author | Buckland, Michael E. | - |
dc.contributor.author | Keam, Simon P. | - |
dc.contributor.author | Hutvagner, Gyorgy | - |
dc.contributor.author | Humphreys, David T. | - |
dc.contributor.author | Langley, Katherine G. | - |
dc.contributor.author | Henstridge, Darren C. | - |
dc.contributor.author | Martin, David I.K. | - |
dc.contributor.author | Febbraio, Mark A. | - |
dc.contributor.author | Suter, Catherine M. | - |
dc.date.accessioned | 2018-10-08T02:46:49Z | - |
dc.date.available | 2018-10-08T02:46:49Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Molecular Metabolism, 2016, v. 5, n. 8, p. 699-708 | - |
dc.identifier.issn | 2212-8778 | - |
dc.identifier.uri | http://hdl.handle.net/10722/262708 | - |
dc.description.abstract | © 2016 The Author(s) Objective Parental obesity can induce metabolic phenotypes in offspring independent of the inherited DNA sequence. Here we asked whether such non-genetic acquired metabolic traits can be passed on to a second generation that has never been exposed to obesity, even as germ cells. Methods We examined the F1, F2, and F3 a/a offspring derived from F0 matings of obese prediabetic Avy/a sires and lean a/a dams. After F0, only lean a/a mice were used for breeding. Results We found that F1 sons of obese founder males exhibited defects in glucose and lipid metabolism, but only upon a post-weaning dietary challenge. F1 males transmitted these defects to their own male progeny (F2) in the absence of the dietary challenge, but the phenotype was largely attenuated by F3. The sperm of F1 males exhibited changes in the abundance of several small RNA species, including the recently reported diet-responsive tRNA-derived fragments. Conclusions These data indicate that induced metabolic phenotypes may be propagated for a generation beyond any direct exposure to an inducing factor. This non-genetic inheritance likely occurs via the actions of sperm noncoding RNA. | - |
dc.language | eng | - |
dc.relation.ispartof | Molecular Metabolism | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Sperm RNA | - |
dc.subject | Epigenetic inheritance | - |
dc.subject | Noncoding RNA | - |
dc.subject | Paternal effects | - |
dc.title | Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1016/j.molmet.2016.06.008 | - |
dc.identifier.scopus | eid_2-s2.0-84978902230 | - |
dc.identifier.volume | 5 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 699 | - |
dc.identifier.epage | 708 | - |
dc.identifier.isi | WOS:000386882400011 | - |
dc.identifier.issnl | 2212-8778 | - |