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Conference Paper: Differences in Metabolite Concentration and fMRI Activation in Subjects with Low and High Genetic Risk during Face-Name Paired-Associates Encoding and Retrieval Task in Healthy Adults
| Title | Differences in Metabolite Concentration and fMRI Activation in Subjects with Low and High Genetic Risk during Face-Name Paired-Associates Encoding and Retrieval Task in Healthy Adults |
|---|---|
| Authors | |
| Issue Date | 2018 |
| Publisher | International Society for Magnetic Resonance in Medicine. |
| Citation | Joint International Society for Magnetic Resonance in Medicine & The European Society for Magnetic Resonance in Medicine and Biology (ISMRM-ESMRMB) Annual Meeting, Paris, France, 16-21 June 2018, p. Abstract #3654 How to Cite? |
| Abstract | APOE-ε4 is an important genetic risk factor of early onset of AD. To investigate the possible differences in metabolite concentration and fMRI activation in subjects with high risk of developing AD (APOE-ɛ4 positive) compared to those with low risk, we employed Face-Name Paired-Associates (FN-PA) Encoding and Retrieval Task and evaluated the absolute concentrations of Glx in bilateral hippocampi and whole brain BOLD signal changes. Significant metabolic and activation differences were observed in the left hippocampus of pre-symptomatic subjects with high genetic risk of developing AD compared to subjects with low risk. |
| Description | Neuro: Genes, Their Correlates & Other Biomarkers - Electronic Poster - no 3654
|
| Persistent Identifier | http://hdl.handle.net/10722/263528 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Zhang, H | - |
| dc.contributor.author | Chiu, PW | - |
| dc.contributor.author | Wong, SWH | - |
| dc.contributor.author | Liu, T | - |
| dc.contributor.author | Wong, GHY | - |
| dc.contributor.author | Chan, Q | - |
| dc.contributor.author | Mak, HKF | - |
| dc.date.accessioned | 2018-10-22T07:40:24Z | - |
| dc.date.available | 2018-10-22T07:40:24Z | - |
| dc.date.issued | 2018 | - |
| dc.identifier.citation | Joint International Society for Magnetic Resonance in Medicine & The European Society for Magnetic Resonance in Medicine and Biology (ISMRM-ESMRMB) Annual Meeting, Paris, France, 16-21 June 2018, p. Abstract #3654 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/263528 | - |
| dc.description | Neuro: Genes, Their Correlates & Other Biomarkers - Electronic Poster - no 3654 | - |
| dc.description.abstract | APOE-ε4 is an important genetic risk factor of early onset of AD. To investigate the possible differences in metabolite concentration and fMRI activation in subjects with high risk of developing AD (APOE-ɛ4 positive) compared to those with low risk, we employed Face-Name Paired-Associates (FN-PA) Encoding and Retrieval Task and evaluated the absolute concentrations of Glx in bilateral hippocampi and whole brain BOLD signal changes. Significant metabolic and activation differences were observed in the left hippocampus of pre-symptomatic subjects with high genetic risk of developing AD compared to subjects with low risk. | - |
| dc.language | eng | - |
| dc.publisher | International Society for Magnetic Resonance in Medicine. | - |
| dc.relation.ispartof | ISMRM-ESMRMB Annual Meeting 2018 | - |
| dc.title | Differences in Metabolite Concentration and fMRI Activation in Subjects with Low and High Genetic Risk during Face-Name Paired-Associates Encoding and Retrieval Task in Healthy Adults | - |
| dc.type | Conference_Paper | - |
| dc.identifier.email | Wong, GHY: ghywong@hku.hk | - |
| dc.identifier.email | Mak, HKF: makkf@hku.hk | - |
| dc.identifier.authority | Wong, GHY=rp01850 | - |
| dc.identifier.authority | Mak, HKF=rp00533 | - |
| dc.identifier.hkuros | 293873 | - |
| dc.identifier.spage | Abstract #3654 | - |
| dc.identifier.epage | Abstract #3654 | - |
| dc.publisher.place | United States | - |