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- Publisher Website: 10.1111/ele.12890
- Scopus: eid_2-s2.0-85037337675
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Article: The impact of host genetic diversity on virus evolution and emergence
Title | The impact of host genetic diversity on virus evolution and emergence |
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Authors | |
Keywords | Biodiversity host genetic diversity parasite emergence rabies virus virus evolution |
Issue Date | 2018 |
Publisher | Wiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1461-0248 |
Citation | Ecology Letters, 2018, v. 21, p. 253-263 How to Cite? |
Abstract | Accumulating evidence indicates that biodiversity has an important impact on parasite evolution and emergence. The vast majority of studies in this area have only considered the diversity of species within an environment as an overall measure of biodiversity, overlooking the role of genetic diversity within a particular host species. Although theoretical models propose that host genetic diversity in part shapes that of the infecting parasite population, and hence modulates the risk of parasite emergence, this effect has seldom been tested empirically. Using Rabies virus (RABV) as a model parasite, we provide evidence that greater host genetic diversity increases both parasite genetic diversity and the likelihood of a host being a donor in RABV cross-species transmission events. We conclude that host genetic diversity may be an important determinant of parasite evolution and emergence. |
Persistent Identifier | http://hdl.handle.net/10722/263776 |
ISSN | 2023 Impact Factor: 7.6 2023 SCImago Journal Rankings: 4.497 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Rodríguez-Nevado, C | - |
dc.contributor.author | Lam, TY | - |
dc.contributor.author | Holmes, EC | - |
dc.contributor.author | Pagán, I | - |
dc.date.accessioned | 2018-10-22T07:44:18Z | - |
dc.date.available | 2018-10-22T07:44:18Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Ecology Letters, 2018, v. 21, p. 253-263 | - |
dc.identifier.issn | 1461-023X | - |
dc.identifier.uri | http://hdl.handle.net/10722/263776 | - |
dc.description.abstract | Accumulating evidence indicates that biodiversity has an important impact on parasite evolution and emergence. The vast majority of studies in this area have only considered the diversity of species within an environment as an overall measure of biodiversity, overlooking the role of genetic diversity within a particular host species. Although theoretical models propose that host genetic diversity in part shapes that of the infecting parasite population, and hence modulates the risk of parasite emergence, this effect has seldom been tested empirically. Using Rabies virus (RABV) as a model parasite, we provide evidence that greater host genetic diversity increases both parasite genetic diversity and the likelihood of a host being a donor in RABV cross-species transmission events. We conclude that host genetic diversity may be an important determinant of parasite evolution and emergence. | - |
dc.language | eng | - |
dc.publisher | Wiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1461-0248 | - |
dc.relation.ispartof | Ecology Letters | - |
dc.rights | Preprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article]. Authors are not required to remove preprints posted prior to acceptance of the submitted version. Postprint This is the accepted version of the following article: [full citation], which has been published in final form at [Link to final article]. | - |
dc.subject | Biodiversity | - |
dc.subject | host genetic diversity | - |
dc.subject | parasite emergence | - |
dc.subject | rabies virus | - |
dc.subject | virus evolution | - |
dc.title | The impact of host genetic diversity on virus evolution and emergence | - |
dc.type | Article | - |
dc.identifier.email | Lam, TY: ttylam@hku.hk | - |
dc.identifier.authority | Lam, TY=rp01733 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/ele.12890 | - |
dc.identifier.scopus | eid_2-s2.0-85037337675 | - |
dc.identifier.hkuros | 294134 | - |
dc.identifier.volume | 21 | - |
dc.identifier.spage | 253 | - |
dc.identifier.epage | 263 | - |
dc.identifier.isi | WOS:000425823900011 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 1461-023X | - |