File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Diagnostic specificity of the insular cortex abnormalities in first-episode psychotic disorders

TitleDiagnostic specificity of the insular cortex abnormalities in first-episode psychotic disorders
Authors
KeywordsSchizophreniform disorder
Affective psychosis
Insula
Magnetic resonance imaging
Schizophrenia
Issue Date2009
Citation
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2009, v. 33, n. 4, p. 651-657 How to Cite?
AbstractVolume reductions of the insular cortex have been described in schizophrenia, but it remains unclear whether other psychotic disorders such as affective psychosis also exhibit insular cortex abnormalities. In this study, we used magnetic resonance imaging to investigate the gray matter volume of the anterior (short) and posterior (long) insular cortices in 162 first-episode patients with various psychotic disorders (46 schizophrenia, 57 schizophreniform disorder, 34 affective psychosis, and 25 other psychoses) and 62 age- and gender-matched healthy comparison subjects. Patients with schizophrenia showed bilateral volume reduction of the anterior and posterior insular cortices compared with controls, but the remaining first-episode psychosis subgroups had normal insular volumes. The volumes of these insular subregions were significantly smaller in schizophrenia patients than in patients with schizophreniform disorder or affective psychoses. There was no association between the insular cortex volume and daily dosage or type of antipsychotic medication in any patient group. These findings suggest that the widespread volume reduction of the insular cortex is specific to established schizophrenia, implicating its role in the neurobiology of clinical characteristics associated with schizophrenia. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/264904
ISSN
2020 Impact Factor: 5.067
2020 SCImago Journal Rankings: 1.716
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTakahashi, Tsutomu-
dc.contributor.authorWood, Stephen J.-
dc.contributor.authorSoulsby, Bridget-
dc.contributor.authorTanino, Ryoichiro-
dc.contributor.authorWong, Michael T.H.-
dc.contributor.authorMcGorry, Patrick D.-
dc.contributor.authorSuzuki, Michio-
dc.contributor.authorVelakoulis, Dennis-
dc.contributor.authorPantelis, Christos-
dc.date.accessioned2018-11-08T01:35:15Z-
dc.date.available2018-11-08T01:35:15Z-
dc.date.issued2009-
dc.identifier.citationProgress in Neuro-Psychopharmacology and Biological Psychiatry, 2009, v. 33, n. 4, p. 651-657-
dc.identifier.issn0278-5846-
dc.identifier.urihttp://hdl.handle.net/10722/264904-
dc.description.abstractVolume reductions of the insular cortex have been described in schizophrenia, but it remains unclear whether other psychotic disorders such as affective psychosis also exhibit insular cortex abnormalities. In this study, we used magnetic resonance imaging to investigate the gray matter volume of the anterior (short) and posterior (long) insular cortices in 162 first-episode patients with various psychotic disorders (46 schizophrenia, 57 schizophreniform disorder, 34 affective psychosis, and 25 other psychoses) and 62 age- and gender-matched healthy comparison subjects. Patients with schizophrenia showed bilateral volume reduction of the anterior and posterior insular cortices compared with controls, but the remaining first-episode psychosis subgroups had normal insular volumes. The volumes of these insular subregions were significantly smaller in schizophrenia patients than in patients with schizophreniform disorder or affective psychoses. There was no association between the insular cortex volume and daily dosage or type of antipsychotic medication in any patient group. These findings suggest that the widespread volume reduction of the insular cortex is specific to established schizophrenia, implicating its role in the neurobiology of clinical characteristics associated with schizophrenia. © 2009 Elsevier Inc. All rights reserved.-
dc.languageeng-
dc.relation.ispartofProgress in Neuro-Psychopharmacology and Biological Psychiatry-
dc.subjectSchizophreniform disorder-
dc.subjectAffective psychosis-
dc.subjectInsula-
dc.subjectMagnetic resonance imaging-
dc.subjectSchizophrenia-
dc.titleDiagnostic specificity of the insular cortex abnormalities in first-episode psychotic disorders-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.pnpbp.2009.03.005-
dc.identifier.pmid19298837-
dc.identifier.scopuseid_2-s2.0-67349107027-
dc.identifier.volume33-
dc.identifier.issue4-
dc.identifier.spage651-
dc.identifier.epage657-
dc.identifier.isiWOS:000266763400011-
dc.identifier.issnl0278-5846-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats