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Article: Amygdala and insula volumes prior to illness onset in bipolar disorder: A magnetic resonance imaging study

TitleAmygdala and insula volumes prior to illness onset in bipolar disorder: A magnetic resonance imaging study
Authors
KeywordsMagnetic resonance imaging
Amygdala
At-risk mental state
Bipolar affective disorder
Issue Date2012
Citation
Psychiatry Research - Neuroimaging, 2012, v. 201, n. 1, p. 34-39 How to Cite?
AbstractThere are now numerous reports of neuroanatomical abnormalities in people with bipolar disorder. However, it remains unclear whether those abnormalities predate the onset of the illness. In this cross-sectional magnetic resonance imaging study, we assessed 11 young people clinically at ultra-high risk of development of psychosis (UHR), who all developed bipolar I or II disorder by follow-up (median time to onset 328. days - UHR-BP), 11 matched UHR participants, who had no psychiatric diagnosis after at least 12. months of follow-up (UHR-Well) and 11 matched healthy controls (HC). Our main outcome measures were amygdala, hippocampus, insula, lateral ventricular and whole brain volumes. Amygdala and insula volume reductions were more pronounced in the UHR-BP than in the UHR-Well and HC group. Lateral ventricle, whole-brain and hippocampal volumes did not differ between groups. If these findings are confirmed, they suggest that imaging investigations could help to distinguish people who will subsequently develop bipolar disorder from those who will not, at least in symptomatically enriched samples. © 2011 Elsevier Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/264926
ISSN
2020 Impact Factor: 2.376
2020 SCImago Journal Rankings: 1.030
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBechdolf, Andreas-
dc.contributor.authorWood, Stephen J.-
dc.contributor.authorNelson, Barnaby-
dc.contributor.authorVelakoulis, Dennis-
dc.contributor.authorYücel, Murat-
dc.contributor.authorTakahashi, Tsutomu-
dc.contributor.authorYung, Alison R.-
dc.contributor.authorBerk, Michael-
dc.contributor.authorWong, Michael T.-
dc.contributor.authorPantelis, Christos-
dc.contributor.authorMcGorry, Patrick D.-
dc.date.accessioned2018-11-08T01:35:19Z-
dc.date.available2018-11-08T01:35:19Z-
dc.date.issued2012-
dc.identifier.citationPsychiatry Research - Neuroimaging, 2012, v. 201, n. 1, p. 34-39-
dc.identifier.issn0925-4927-
dc.identifier.urihttp://hdl.handle.net/10722/264926-
dc.description.abstractThere are now numerous reports of neuroanatomical abnormalities in people with bipolar disorder. However, it remains unclear whether those abnormalities predate the onset of the illness. In this cross-sectional magnetic resonance imaging study, we assessed 11 young people clinically at ultra-high risk of development of psychosis (UHR), who all developed bipolar I or II disorder by follow-up (median time to onset 328. days - UHR-BP), 11 matched UHR participants, who had no psychiatric diagnosis after at least 12. months of follow-up (UHR-Well) and 11 matched healthy controls (HC). Our main outcome measures were amygdala, hippocampus, insula, lateral ventricular and whole brain volumes. Amygdala and insula volume reductions were more pronounced in the UHR-BP than in the UHR-Well and HC group. Lateral ventricle, whole-brain and hippocampal volumes did not differ between groups. If these findings are confirmed, they suggest that imaging investigations could help to distinguish people who will subsequently develop bipolar disorder from those who will not, at least in symptomatically enriched samples. © 2011 Elsevier Ireland Ltd.-
dc.languageeng-
dc.relation.ispartofPsychiatry Research - Neuroimaging-
dc.subjectMagnetic resonance imaging-
dc.subjectAmygdala-
dc.subjectAt-risk mental state-
dc.subjectBipolar affective disorder-
dc.titleAmygdala and insula volumes prior to illness onset in bipolar disorder: A magnetic resonance imaging study-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.pscychresns.2011.06.010-
dc.identifier.pmid22281200-
dc.identifier.scopuseid_2-s2.0-84862820880-
dc.identifier.volume201-
dc.identifier.issue1-
dc.identifier.spage34-
dc.identifier.epage39-
dc.identifier.eissn1872-7506-
dc.identifier.isiWOS:000301805400005-
dc.identifier.issnl0925-4927-

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