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Article: Changes in serum thyroglobulin and antithyroglobulin shortly following high-intensity focused ablation of benign thyroid nodules in patients with positive antithyroglobulin status
Title | Changes in serum thyroglobulin and antithyroglobulin shortly following high-intensity focused ablation of benign thyroid nodules in patients with positive antithyroglobulin status |
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Authors | |
Keywords | Anti-thyroglobulin autoantibody Benign thyroid nodule Focused ultrasound Thermal ablation Thyroiditis |
Issue Date | 2019 |
Publisher | Informa Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/02656736.asp |
Citation | International Journal of Hyperthermia, 2019, v. 35 n. 1, p. 637-643 How to Cite? |
Abstract | Background: We aimed to describe changes in serum thyroglobulin (Tg) and anti-Tg autoantibody shortly following high-intensity focused ultrasound (HIFU) ablation in patients with positive anti-Tg status by comparing them with patients with negative anti-Tg and to correlate them with 6-month nodule shrinkage and treatment success. Methods: From 2015 to 2017, patients who underwent HIFU ablation of a benign thyroid nodule were analysed. Serum Tg and anti-Tg were checked on treatment day (baseline) and 4 days after treatment. Anti-Tg >99 IU/ml were considered positivity. Percentage Tg or anti-Tg change = [Level on Day-4–baseline level]/[Baseline level] × 100 while nodule shrinkage was measured by volume reduction ratio (VRR) = [Baseline volume–volume at 6 month]/[Baseline volume] × 100. Treatment success was defined as VRR >50%. Results: Among the 276 eligible patients, 85 (30.8%) patients were positive for anti-Tg (Group I) while the others (n = 191, 69.2%) were negative (Group II). Relative to group II, Group I had a less significant Tg rise on Day 4 (4121.78 ± 9321.90% vs. 5711.53 ± 23487.20%, p =.013). There was a fall in anti-Tg on day 4 for group I (−11.56 ± 139.69%). This percentage anti-Tg drop significantly correlated with the 6-month VRR (ρ = −0.602, p =.030) but was not a significant factor of treatment success. Conclusions: Given the fact that the percentage anti-Tg drop correlated significantly with 6-month nodule shrinkage in group I, monitoring early anti-Tg change may help to predict the 6-month nodule shrinkage in patients with positive anti-Tg. |
Persistent Identifier | http://hdl.handle.net/10722/265104 |
ISSN | 2023 Impact Factor: 3.0 2023 SCImago Journal Rankings: 0.827 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lang, HHB | - |
dc.contributor.author | Woo, YC | - |
dc.contributor.author | Chiu, WHK | - |
dc.date.accessioned | 2018-11-20T02:00:14Z | - |
dc.date.available | 2018-11-20T02:00:14Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | International Journal of Hyperthermia, 2019, v. 35 n. 1, p. 637-643 | - |
dc.identifier.issn | 0265-6736 | - |
dc.identifier.uri | http://hdl.handle.net/10722/265104 | - |
dc.description.abstract | Background: We aimed to describe changes in serum thyroglobulin (Tg) and anti-Tg autoantibody shortly following high-intensity focused ultrasound (HIFU) ablation in patients with positive anti-Tg status by comparing them with patients with negative anti-Tg and to correlate them with 6-month nodule shrinkage and treatment success. Methods: From 2015 to 2017, patients who underwent HIFU ablation of a benign thyroid nodule were analysed. Serum Tg and anti-Tg were checked on treatment day (baseline) and 4 days after treatment. Anti-Tg >99 IU/ml were considered positivity. Percentage Tg or anti-Tg change = [Level on Day-4–baseline level]/[Baseline level] × 100 while nodule shrinkage was measured by volume reduction ratio (VRR) = [Baseline volume–volume at 6 month]/[Baseline volume] × 100. Treatment success was defined as VRR >50%. Results: Among the 276 eligible patients, 85 (30.8%) patients were positive for anti-Tg (Group I) while the others (n = 191, 69.2%) were negative (Group II). Relative to group II, Group I had a less significant Tg rise on Day 4 (4121.78 ± 9321.90% vs. 5711.53 ± 23487.20%, p =.013). There was a fall in anti-Tg on day 4 for group I (−11.56 ± 139.69%). This percentage anti-Tg drop significantly correlated with the 6-month VRR (ρ = −0.602, p =.030) but was not a significant factor of treatment success. Conclusions: Given the fact that the percentage anti-Tg drop correlated significantly with 6-month nodule shrinkage in group I, monitoring early anti-Tg change may help to predict the 6-month nodule shrinkage in patients with positive anti-Tg. | - |
dc.language | eng | - |
dc.publisher | Informa Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/02656736.asp | - |
dc.relation.ispartof | International Journal of Hyperthermia | - |
dc.rights | International Journal of Hyperthermia. Copyright © Informa Healthcare. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Anti-thyroglobulin autoantibody | - |
dc.subject | Benign thyroid nodule | - |
dc.subject | Focused ultrasound | - |
dc.subject | Thermal ablation | - |
dc.subject | Thyroiditis | - |
dc.title | Changes in serum thyroglobulin and antithyroglobulin shortly following high-intensity focused ablation of benign thyroid nodules in patients with positive antithyroglobulin status | - |
dc.type | Article | - |
dc.identifier.email | Lang, HHB: Blang@hku.hk | - |
dc.identifier.email | Woo, YC: wooyucho@hku.hk | - |
dc.identifier.email | Chiu, WHK: kwhchiu@hku.hk | - |
dc.identifier.authority | Lang, HHB=rp01828 | - |
dc.identifier.authority | Chiu, WHK=rp02074 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1080/02656736.2018.1516302 | - |
dc.identifier.pmid | 30303432 | - |
dc.identifier.scopus | eid_2-s2.0-85054879568 | - |
dc.identifier.hkuros | 295985 | - |
dc.identifier.volume | 35 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 637 | - |
dc.identifier.epage | 643 | - |
dc.identifier.isi | WOS:000457964800001 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0265-6736 | - |