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Article: A propensity-matched analysis of clinical outcomes between open thyroid lobectomy and high-intensity focused ultrasound (HIFU) ablation of benign thyroid nodules

TitleA propensity-matched analysis of clinical outcomes between open thyroid lobectomy and high-intensity focused ultrasound (HIFU) ablation of benign thyroid nodules
Authors
Issue Date2019
PublisherMosby, Inc. The Journal's web site is located at http://www.medicinepublishing.co.uk/index.php/surgery/
Citation
Surgery, 2019, v. 165 n. 1, p. 85-91 How to Cite?
AbstractBackground High-intensity focused ultrasound is a promising, nonoperative treatment for benign thyroid nodules. Our study aimed to compare treatment outcomes of single-session high-intensity focused ultrasound ablation with open lobectomy after propensity score matching. Methods After propensity matching, we compared treatment-related morbidity, treatment time, duration of hospitalization, improvement in symptom score, cost, and acoustic parameters of consecutive patients who underwent high-intensity focused ultrasound ablation or lobectomy. All eligible patients completed the computerized, multidimensional voice program and Voice Handicap Index questionnaire before, and 3 and 6 months after treatment. Results The matched cohort comprised 154 patients (77 in each group). Although treatment-related morbidity was comparable between the two groups (P = .368), treatment time (P <.001), duration of hospitalization (P <.001), and medical cost (P <.001) were less in the high-intensity focused ultrasound group. After high-intensity focused ultrasound ablation, the 6-month nodule shrinkage (mean ± SD) was 64% ± 26% and the 6-month symptom improvement score was comparable with lobectomy (P = .283). At 6 months, none of the acoustic parameters were changed from the baseline in both groups (P >.05), and the Voice Handicap Index questionnaire did not differ between the two groups (P >.05). Conclusion Despite having similar treatment-related morbidity and voice outcomes, there were possibly some advantages with high-intensity focused ultrasound during open lobectomy, including the avoidance of a neck scar, shorter treatment time and duration of hospitalization, and lower medical cost.
Persistent Identifierhttp://hdl.handle.net/10722/265105
ISSN
2019 Impact Factor: 3.356
2015 SCImago Journal Rankings: 1.620
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLang, HHB-
dc.contributor.authorWong, CKH-
dc.contributor.authorMa, EPM-
dc.contributor.authorWoo, YC-
dc.contributor.authorChiu, WHK-
dc.date.accessioned2018-11-20T02:00:15Z-
dc.date.available2018-11-20T02:00:15Z-
dc.date.issued2019-
dc.identifier.citationSurgery, 2019, v. 165 n. 1, p. 85-91-
dc.identifier.issn0039-6060-
dc.identifier.urihttp://hdl.handle.net/10722/265105-
dc.description.abstractBackground High-intensity focused ultrasound is a promising, nonoperative treatment for benign thyroid nodules. Our study aimed to compare treatment outcomes of single-session high-intensity focused ultrasound ablation with open lobectomy after propensity score matching. Methods After propensity matching, we compared treatment-related morbidity, treatment time, duration of hospitalization, improvement in symptom score, cost, and acoustic parameters of consecutive patients who underwent high-intensity focused ultrasound ablation or lobectomy. All eligible patients completed the computerized, multidimensional voice program and Voice Handicap Index questionnaire before, and 3 and 6 months after treatment. Results The matched cohort comprised 154 patients (77 in each group). Although treatment-related morbidity was comparable between the two groups (P = .368), treatment time (P <.001), duration of hospitalization (P <.001), and medical cost (P <.001) were less in the high-intensity focused ultrasound group. After high-intensity focused ultrasound ablation, the 6-month nodule shrinkage (mean ± SD) was 64% ± 26% and the 6-month symptom improvement score was comparable with lobectomy (P = .283). At 6 months, none of the acoustic parameters were changed from the baseline in both groups (P >.05), and the Voice Handicap Index questionnaire did not differ between the two groups (P >.05). Conclusion Despite having similar treatment-related morbidity and voice outcomes, there were possibly some advantages with high-intensity focused ultrasound during open lobectomy, including the avoidance of a neck scar, shorter treatment time and duration of hospitalization, and lower medical cost.-
dc.languageeng-
dc.publisherMosby, Inc. The Journal's web site is located at http://www.medicinepublishing.co.uk/index.php/surgery/-
dc.relation.ispartofSurgery-
dc.titleA propensity-matched analysis of clinical outcomes between open thyroid lobectomy and high-intensity focused ultrasound (HIFU) ablation of benign thyroid nodules-
dc.typeArticle-
dc.identifier.emailLang, HHB: Blang@hku.hk-
dc.identifier.emailWong, CKH: carlosho@hku.hk-
dc.identifier.emailMa, EPM: estella1@hku.hk-
dc.identifier.emailWoo, YC: wooyucho@hku.hk-
dc.identifier.emailChiu, WHK: kwhchiu@hku.hk-
dc.identifier.authorityLang, HHB=rp01828-
dc.identifier.authorityWong, CKH=rp01931-
dc.identifier.authorityMa, EPM=rp00933-
dc.identifier.authorityChiu, WHK=rp02074-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.surg.2018.05.080-
dc.identifier.pmid30392858-
dc.identifier.scopuseid_2-s2.0-85055754035-
dc.identifier.hkuros296071-
dc.identifier.volume165-
dc.identifier.issue1-
dc.identifier.spage85-
dc.identifier.epage91-
dc.identifier.isiWOS:000454471900015-
dc.publisher.placeUnited States-
dc.identifier.issnl0039-6060-

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