File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Early-Stage Negative Symptom Trajectories and Relationships With 13-Year Outcomes in First-Episode Nonaffective Psychosis

TitleEarly-Stage Negative Symptom Trajectories and Relationships With 13-Year Outcomes in First-Episode Nonaffective Psychosis
Authors
KeywordsLongitudinal course
First-episode psychosis
Latent class growth analysis
Prospective follow-up
Functional outcome
Issue Date2019
PublisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/
Citation
Schizophrenia Bulletin, 2019, v. 45 n. 3, p. 610-619 How to Cite?
AbstractNegative symptoms are a key treatment target in early psychosis intervention. There is a paucity of research examining longitudinal course of negative symptoms across the initial years of treatment for first-episode psychosis using individual-based trajectory analysis. No study has been conducted investigating differential relationships of early-stage negative symptom trajectories with long-term distal outcomes. This study examined patterns and baseline predictors of negative symptom trajectories over the first 3 years of treatment in 138 patients aged 18–55 years presenting with first-episode nonaffective psychosis, using latent class growth analysis based on symptom ratings measured at 4 different time points (baseline, 1, 2, and 3 years). We further explored prospective relationships of identified trajectory classes with functional and negative symptom outcomes at 13-year follow-up. Our results revealed 3 distinct negative symptom trajectories including minimal-stable (59.6%), mild-stable (29.4%), and high-increasing (11.0%) trajectories. Poorer premorbid adjustment, more severe global cognitive impairment, and depressive symptoms at baseline were found to predict high-increasing trajectory. Among 3 trajectory classes, patients in high-increasing trajectory had the worst functional and negative symptom outcomes at 13-year follow-up, with post hoc analyses demonstrating significant outcome differences between high-increasing and minimal-stable trajectories. Our findings thus affirm a heterogeneous course of negative symptoms in first-episode psychosis and indicate that early-stage negative symptom trajectories are critically associated with long-term outcomes. Patients displaying persistently high negative symptom levels in the initial 3 years of treatment may represent a specific subgroup who necessitates an extended period of early intervention specifically targeting at negative symptoms to promote early functional recovery.
Persistent Identifierhttp://hdl.handle.net/10722/265135
ISSN
2023 Impact Factor: 5.3
2023 SCImago Journal Rankings: 2.249
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChang, WC-
dc.contributor.authorHo, RWH-
dc.contributor.authorTang, JYM-
dc.contributor.authorWong, SMC-
dc.contributor.authorHui, CLM-
dc.contributor.authorChan, KW-
dc.contributor.authorLee, HME-
dc.contributor.authorSuen, YN-
dc.contributor.authorChen, EYH-
dc.date.accessioned2018-11-20T02:00:50Z-
dc.date.available2018-11-20T02:00:50Z-
dc.date.issued2019-
dc.identifier.citationSchizophrenia Bulletin, 2019, v. 45 n. 3, p. 610-619-
dc.identifier.issn0586-7614-
dc.identifier.urihttp://hdl.handle.net/10722/265135-
dc.description.abstractNegative symptoms are a key treatment target in early psychosis intervention. There is a paucity of research examining longitudinal course of negative symptoms across the initial years of treatment for first-episode psychosis using individual-based trajectory analysis. No study has been conducted investigating differential relationships of early-stage negative symptom trajectories with long-term distal outcomes. This study examined patterns and baseline predictors of negative symptom trajectories over the first 3 years of treatment in 138 patients aged 18–55 years presenting with first-episode nonaffective psychosis, using latent class growth analysis based on symptom ratings measured at 4 different time points (baseline, 1, 2, and 3 years). We further explored prospective relationships of identified trajectory classes with functional and negative symptom outcomes at 13-year follow-up. Our results revealed 3 distinct negative symptom trajectories including minimal-stable (59.6%), mild-stable (29.4%), and high-increasing (11.0%) trajectories. Poorer premorbid adjustment, more severe global cognitive impairment, and depressive symptoms at baseline were found to predict high-increasing trajectory. Among 3 trajectory classes, patients in high-increasing trajectory had the worst functional and negative symptom outcomes at 13-year follow-up, with post hoc analyses demonstrating significant outcome differences between high-increasing and minimal-stable trajectories. Our findings thus affirm a heterogeneous course of negative symptoms in first-episode psychosis and indicate that early-stage negative symptom trajectories are critically associated with long-term outcomes. Patients displaying persistently high negative symptom levels in the initial 3 years of treatment may represent a specific subgroup who necessitates an extended period of early intervention specifically targeting at negative symptoms to promote early functional recovery.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/-
dc.relation.ispartofSchizophrenia Bulletin-
dc.subjectLongitudinal course-
dc.subjectFirst-episode psychosis-
dc.subjectLatent class growth analysis-
dc.subjectProspective follow-up-
dc.subjectFunctional outcome-
dc.titleEarly-Stage Negative Symptom Trajectories and Relationships With 13-Year Outcomes in First-Episode Nonaffective Psychosis-
dc.typeArticle-
dc.identifier.emailChang, WC: changwc@hku.hk-
dc.identifier.emailWong, SMC: wongcsm@hku.hk-
dc.identifier.emailHui, CLM: christyh@hku.hk-
dc.identifier.emailChan, KW: kwsherry@hku.hk-
dc.identifier.emailLee, HME: edwinlhm@hku.hk-
dc.identifier.emailSuen, YN: suenyn@hku.hk-
dc.identifier.emailChen, EYH: eyhchen@hku.hk-
dc.identifier.authorityChang, WC=rp01465-
dc.identifier.authorityHui, CLM=rp01993-
dc.identifier.authorityChan, KW=rp00539-
dc.identifier.authorityLee, HME=rp01575-
dc.identifier.authorityChen, EYH=rp00392-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/schbul/sby115-
dc.identifier.scopuseid_2-s2.0-85065485858-
dc.identifier.hkuros295888-
dc.identifier.volume45-
dc.identifier.issue3-
dc.identifier.spage610-
dc.identifier.epage619-
dc.identifier.isiWOS:000493374900017-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl0586-7614-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats