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- Publisher Website: 10.1038/embor.2010.144
- Scopus: eid_2-s2.0-78049334564
- PMID: 20930845
- WOS: WOS:000283507900016
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Article: Maternal phosphatidylinositol 3-kinase signalling is crucial for embryonic genome activation and preimplantation embryogenesis
Title | Maternal phosphatidylinositol 3-kinase signalling is crucial for embryonic genome activation and preimplantation embryogenesis |
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Authors | |
Keywords | PDK1 PTEN maternal effect factor oocyte PI3K signalling preimplantation embryogenesis |
Issue Date | 2010 |
Citation | EMBO Reports, 2010, v. 11, n. 11, p. 890-895 How to Cite? |
Abstract | Maternal effect factors derived from oocytes are important for sustaining early embryonic development before the major wave of embryonic genome activation (EGA). In this study, we report a two-cell-stage arrest of embryos lacking maternal 3-phosphoinositide-dependent protein kinase 1 as a result of suppressed EGA. Concurrent deletion of maternal Pten completely rescued the suppressed EGA and embryonic progression through restored AKT signalling, which fully restored the fertility of double-mutant females. Our study identifies maternal phosphatidylinositol 3-kinase signalling as a new maternal effect factor that regulates EGA and preimplantation embryogenesis in mice. © 2010 European Molecular Biology Organization. |
Persistent Identifier | http://hdl.handle.net/10722/265421 |
ISSN | 2023 Impact Factor: 6.5 2023 SCImago Journal Rankings: 3.193 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zheng, Wenjing | - |
dc.contributor.author | Gorre, Nagaraju | - |
dc.contributor.author | Shen, Yan | - |
dc.contributor.author | Noda, Tetsuo | - |
dc.contributor.author | Ogawa, Wataru | - |
dc.contributor.author | Lundin, Eva | - |
dc.contributor.author | Liu, Kui | - |
dc.date.accessioned | 2018-12-03T01:20:36Z | - |
dc.date.available | 2018-12-03T01:20:36Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | EMBO Reports, 2010, v. 11, n. 11, p. 890-895 | - |
dc.identifier.issn | 1469-221X | - |
dc.identifier.uri | http://hdl.handle.net/10722/265421 | - |
dc.description.abstract | Maternal effect factors derived from oocytes are important for sustaining early embryonic development before the major wave of embryonic genome activation (EGA). In this study, we report a two-cell-stage arrest of embryos lacking maternal 3-phosphoinositide-dependent protein kinase 1 as a result of suppressed EGA. Concurrent deletion of maternal Pten completely rescued the suppressed EGA and embryonic progression through restored AKT signalling, which fully restored the fertility of double-mutant females. Our study identifies maternal phosphatidylinositol 3-kinase signalling as a new maternal effect factor that regulates EGA and preimplantation embryogenesis in mice. © 2010 European Molecular Biology Organization. | - |
dc.language | eng | - |
dc.relation.ispartof | EMBO Reports | - |
dc.subject | PDK1 | - |
dc.subject | PTEN | - |
dc.subject | maternal effect factor | - |
dc.subject | oocyte PI3K signalling | - |
dc.subject | preimplantation embryogenesis | - |
dc.title | Maternal phosphatidylinositol 3-kinase signalling is crucial for embryonic genome activation and preimplantation embryogenesis | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1038/embor.2010.144 | - |
dc.identifier.pmid | 20930845 | - |
dc.identifier.scopus | eid_2-s2.0-78049334564 | - |
dc.identifier.volume | 11 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 890 | - |
dc.identifier.epage | 895 | - |
dc.identifier.eissn | 1469-3178 | - |
dc.identifier.isi | WOS:000283507900016 | - |
dc.identifier.issnl | 1469-221X | - |