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Article: Regulation of tissue-type plasminogen activator and plasminogen activator inhibitor type-1 in cultured rat Sertoli and Leydig cells
Title | Regulation of tissue-type plasminogen activator and plasminogen activator inhibitor type-1 in cultured rat Sertoli and Leydig cells |
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Authors | |
Keywords | Tissue type plasminogen activator Leydig cells Plasminogen activator inhibitor type-1 Sertoli cells |
Issue Date | 1996 |
Citation | Science in China, Series C: Life Sciences, 1996, v. 39, n. 1, p. 37-44 How to Cite? |
Abstract | New data are provided to show that (i) rat Sertoli cells produce two types of plasminogen activators, tissue type (tPA) and urokinase type (uPA), and a plasminogen activator inhibitor type-1 (PAI-1); (ii) both tPA (but not uPA) and PAI-1 secretion in the culture are modified by FSH, forskolin, dbcAMP, GnRH, PMA and growth factors (EGF and FGF), but not by hCG and androstenedione (Δ4); (iii) in vitro secretion of tPA and PA-PAI-1 complexes of Sertoli cells are greatly enhanced by presence of Leydig cells which produce negligible tPA but measurable PAI-1 activity;(iv) combination culture of Sertoli and Leydig cells remarkably increases FSH-induced PAI-1 activity and decreases hCG- and forskolin-induced inhibitor activity as compared with that of two cell types cultured alone. These data suggest that rat Sertoli cells, similar to ovarian granulosa cells, are capable of secreting both tPA and uPA, as well as PAI-1. The interaction of Sertoli cells and Leydig cells is essential for the cells to response to hormone stimulation for tPA and PAT-1 secretion. |
Persistent Identifier | http://hdl.handle.net/10722/265448 |
ISSN | 2011 Impact Factor: 1.610 |
DC Field | Value | Language |
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dc.contributor.author | Liu, Yixun | - |
dc.contributor.author | Du, Qun | - |
dc.contributor.author | Zhou, Hongming | - |
dc.contributor.author | Liu, Kui | - |
dc.contributor.author | Hu, Zhaoyuan | - |
dc.date.accessioned | 2018-12-03T01:20:41Z | - |
dc.date.available | 2018-12-03T01:20:41Z | - |
dc.date.issued | 1996 | - |
dc.identifier.citation | Science in China, Series C: Life Sciences, 1996, v. 39, n. 1, p. 37-44 | - |
dc.identifier.issn | 1006-9305 | - |
dc.identifier.uri | http://hdl.handle.net/10722/265448 | - |
dc.description.abstract | New data are provided to show that (i) rat Sertoli cells produce two types of plasminogen activators, tissue type (tPA) and urokinase type (uPA), and a plasminogen activator inhibitor type-1 (PAI-1); (ii) both tPA (but not uPA) and PAI-1 secretion in the culture are modified by FSH, forskolin, dbcAMP, GnRH, PMA and growth factors (EGF and FGF), but not by hCG and androstenedione (Δ4); (iii) in vitro secretion of tPA and PA-PAI-1 complexes of Sertoli cells are greatly enhanced by presence of Leydig cells which produce negligible tPA but measurable PAI-1 activity;(iv) combination culture of Sertoli and Leydig cells remarkably increases FSH-induced PAI-1 activity and decreases hCG- and forskolin-induced inhibitor activity as compared with that of two cell types cultured alone. These data suggest that rat Sertoli cells, similar to ovarian granulosa cells, are capable of secreting both tPA and uPA, as well as PAI-1. The interaction of Sertoli cells and Leydig cells is essential for the cells to response to hormone stimulation for tPA and PAT-1 secretion. | - |
dc.language | eng | - |
dc.relation.ispartof | Science in China, Series C: Life Sciences | - |
dc.subject | Tissue type plasminogen activator | - |
dc.subject | Leydig cells | - |
dc.subject | Plasminogen activator inhibitor type-1 | - |
dc.subject | Sertoli cells | - |
dc.title | Regulation of tissue-type plasminogen activator and plasminogen activator inhibitor type-1 in cultured rat Sertoli and Leydig cells | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.pmid | 8760471 | - |
dc.identifier.scopus | eid_2-s2.0-0030077402 | - |
dc.identifier.volume | 39 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 37 | - |
dc.identifier.epage | 44 | - |
dc.identifier.issnl | 1006-9305 | - |