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Article: Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II

TitleMastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II
Authors
Issue Date2014
Citation
Journal of Cell Biology, 2014, v. 206, n. 7, p. 843-853 How to Cite?
Abstract© 2014 Adhikari et al. In mitosis, the Greatwall kinase (called microtubuleassociated serine/threonine kinase like [Mastl] in mammals)is essential for prometaphase entry or progression by suppressing protein phosphatase 2A (PP2A) activity. PP2A suppression in turn leads to high levels of Cdk1 substrate phosphorylation. We have used a mouse model with an oocyte-specific deletion of Mastl to show that Mastl-null oocytes resume meiosis I and reach metaphase I normally but that the onset and completion of anaphase I are delayed. Moreover, after the completion of meiosis I, Mastl-null oocytes failed to enter meiosis II (MII) because they reassembled a nuclear structure containing decondensed chromatin. Our results show that Mastl is required for the timely activation of anaphase-promoting complex/cyclosome to allow meiosis I exit and for the rapid rise of Cdk1 activity that is needed for the entry into MII in mouse oocytes.
Persistent Identifierhttp://hdl.handle.net/10722/265490
ISSN
2023 Impact Factor: 7.4
2023 SCImago Journal Rankings: 3.717
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAdhikari, Deepak-
dc.contributor.authorDiril, M. Kasim-
dc.contributor.authorBusayavalasa, Kiran-
dc.contributor.authorRisal, Sanjiv-
dc.contributor.authorNakagawa, Shoma-
dc.contributor.authorLindkvist, Rebecca-
dc.contributor.authorShen, Yan-
dc.contributor.authorCoppola, Vincenzo-
dc.contributor.authorTessarollo, Lino-
dc.contributor.authorKudo, Nobuaki R.-
dc.contributor.authorKaldis, Philipp-
dc.contributor.authorLiu, Kui-
dc.date.accessioned2018-12-03T01:20:49Z-
dc.date.available2018-12-03T01:20:49Z-
dc.date.issued2014-
dc.identifier.citationJournal of Cell Biology, 2014, v. 206, n. 7, p. 843-853-
dc.identifier.issn0021-9525-
dc.identifier.urihttp://hdl.handle.net/10722/265490-
dc.description.abstract© 2014 Adhikari et al. In mitosis, the Greatwall kinase (called microtubuleassociated serine/threonine kinase like [Mastl] in mammals)is essential for prometaphase entry or progression by suppressing protein phosphatase 2A (PP2A) activity. PP2A suppression in turn leads to high levels of Cdk1 substrate phosphorylation. We have used a mouse model with an oocyte-specific deletion of Mastl to show that Mastl-null oocytes resume meiosis I and reach metaphase I normally but that the onset and completion of anaphase I are delayed. Moreover, after the completion of meiosis I, Mastl-null oocytes failed to enter meiosis II (MII) because they reassembled a nuclear structure containing decondensed chromatin. Our results show that Mastl is required for the timely activation of anaphase-promoting complex/cyclosome to allow meiosis I exit and for the rapid rise of Cdk1 activity that is needed for the entry into MII in mouse oocytes.-
dc.languageeng-
dc.relation.ispartofJournal of Cell Biology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleMastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1083/jcb.201406033-
dc.identifier.pmid25246615-
dc.identifier.scopuseid_2-s2.0-84907764457-
dc.identifier.volume206-
dc.identifier.issue7-
dc.identifier.spage843-
dc.identifier.epage853-
dc.identifier.eissn1540-8140-
dc.identifier.isiWOS:000342539500006-
dc.identifier.f1000718885762-
dc.identifier.issnl0021-9525-

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