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Article: p27KIP1 and PTEN cooperate in myeloproliferative neoplasm tumor suppression in mice
Title | p27KIP1 and PTEN cooperate in myeloproliferative neoplasm tumor suppression in mice |
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Authors | |
Keywords | Myeloproliferative neoplasms PTEN p27 KIP1 |
Issue Date | 2016 |
Citation | Experimental Hematology and Oncology, 2016, v. 5, n. 17 How to Cite? |
Abstract | © 2016 Shao et al. PTEN acts as a phosphatase for PIP3 and negatively regulates the PI3K/AKT pathway, and p27KIP1 is a cyclin-dependent kinase inhibitor that regulates the G1 to S-phase transition by binding to and regulating the activity of cyclin-dependent kinases. Genetic alterations of PTEN or CDKN1B (p27KIP1) are common in hematological malignancies. To better understand how mutations in these two genes might cooperate in leukemogenesis, we inactivated both genes in the hematological compartment in mice. Here, we show that the combined inactivation of Pten and Cdkn1b results in a more severe myeloproliferative neoplasm phenotype associated with lower hemoglobin, enlarged spleen and liver, and shorter lifespan compared to inactivation of Pten alone. More severe anemia and increased myeloid infiltration and destruction of the spleen contributed to the earlier death of these mice, and elevated p-AKT, cyclin D1, and cyclin D3 might contribute to the development of this phenotype. In conclusion, PTEN and p27KIP1 cooperate in tumor suppression in the hematological compartment. |
Description | Letter to the Editor |
Persistent Identifier | http://hdl.handle.net/10722/265505 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Shao, Jingchen | - |
dc.contributor.author | Li, Susann | - |
dc.contributor.author | Palmqvist, Lars | - |
dc.contributor.author | Fogelstrand, Linda | - |
dc.contributor.author | Wei, Stella Y. | - |
dc.contributor.author | Busayavalasa, Kiran | - |
dc.contributor.author | Liu, Kui | - |
dc.contributor.author | Liu, Viktor M. | - |
dc.date.accessioned | 2018-12-03T01:20:52Z | - |
dc.date.available | 2018-12-03T01:20:52Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Experimental Hematology and Oncology, 2016, v. 5, n. 17 | - |
dc.identifier.uri | http://hdl.handle.net/10722/265505 | - |
dc.description | Letter to the Editor | - |
dc.description.abstract | © 2016 Shao et al. PTEN acts as a phosphatase for PIP3 and negatively regulates the PI3K/AKT pathway, and p27KIP1 is a cyclin-dependent kinase inhibitor that regulates the G1 to S-phase transition by binding to and regulating the activity of cyclin-dependent kinases. Genetic alterations of PTEN or CDKN1B (p27KIP1) are common in hematological malignancies. To better understand how mutations in these two genes might cooperate in leukemogenesis, we inactivated both genes in the hematological compartment in mice. Here, we show that the combined inactivation of Pten and Cdkn1b results in a more severe myeloproliferative neoplasm phenotype associated with lower hemoglobin, enlarged spleen and liver, and shorter lifespan compared to inactivation of Pten alone. More severe anemia and increased myeloid infiltration and destruction of the spleen contributed to the earlier death of these mice, and elevated p-AKT, cyclin D1, and cyclin D3 might contribute to the development of this phenotype. In conclusion, PTEN and p27KIP1 cooperate in tumor suppression in the hematological compartment. | - |
dc.language | eng | - |
dc.relation.ispartof | Experimental Hematology and Oncology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Myeloproliferative neoplasms | - |
dc.subject | PTEN | - |
dc.subject | p27 KIP1 | - |
dc.title | p27KIP1 and PTEN cooperate in myeloproliferative neoplasm tumor suppression in mice | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1186/s40164-016-0047-0 | - |
dc.identifier.scopus | eid_2-s2.0-85006226037 | - |
dc.identifier.volume | 5 | - |
dc.identifier.issue | 17 | - |
dc.identifier.spage | null | - |
dc.identifier.epage | null | - |
dc.identifier.eissn | 2162-3619 | - |
dc.identifier.isi | WOS:000381115600001 | - |
dc.identifier.issnl | 2162-3619 | - |