File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.bbrc.2008.04.062
- Scopus: eid_2-s2.0-44149087821
- PMID: 18435908
- WOS: WOS:000256506600015
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Low concentration of condensed tannins from catechu significantly inhibits fatty acid synthase and growth of MCF-7 cells
Title | Low concentration of condensed tannins from catechu significantly inhibits fatty acid synthase and growth of MCF-7 cells |
---|---|
Authors | |
Keywords | Cancer Condensed tannin Fatty acid synthase Inhibition |
Issue Date | 2008 |
Citation | Biochemical and Biophysical Research Communications, 2008, v. 371, n. 4, p. 654-658 How to Cite? |
Abstract | Tannins exist widely in plants, but because they precipitate proteins, scientists frequently ignore them in search of bioactive components. Catechu, a traditional astringent, is rich in tannins. In this study, we found that condensed tannins from catechu potently inhibited animal fatty acid synthase (FAS). Among them, trimeric condensed tannin showed the most potent inhibition with IC50of 0.47 μg/ml and it also exhibited strong time-dependent inhibition. Its inhibitory kinetics and reacting sites on FAS were obviously different from the known inhibitors of FAS. Furthermore, condensed tannins were found to suppress the growth of MCF-7 breast cancer cells, and the effect was related to their activity of FAS inhibition. The inhibition of both FAS activity and MCF-7 growth was exhibited by low concentrations of condensed tannins without FAS being precipitated. These results suggest tannins would be a valuable resource of bioactive substances. © 2008 Elsevier Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/265539 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.770 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhang, Shu Yan | - |
dc.contributor.author | Zheng, Chao Gu | - |
dc.contributor.author | Yan, Xi Yun | - |
dc.contributor.author | Tian, Wei Xi | - |
dc.date.accessioned | 2018-12-03T01:20:58Z | - |
dc.date.available | 2018-12-03T01:20:58Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications, 2008, v. 371, n. 4, p. 654-658 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10722/265539 | - |
dc.description.abstract | Tannins exist widely in plants, but because they precipitate proteins, scientists frequently ignore them in search of bioactive components. Catechu, a traditional astringent, is rich in tannins. In this study, we found that condensed tannins from catechu potently inhibited animal fatty acid synthase (FAS). Among them, trimeric condensed tannin showed the most potent inhibition with IC50of 0.47 μg/ml and it also exhibited strong time-dependent inhibition. Its inhibitory kinetics and reacting sites on FAS were obviously different from the known inhibitors of FAS. Furthermore, condensed tannins were found to suppress the growth of MCF-7 breast cancer cells, and the effect was related to their activity of FAS inhibition. The inhibition of both FAS activity and MCF-7 growth was exhibited by low concentrations of condensed tannins without FAS being precipitated. These results suggest tannins would be a valuable resource of bioactive substances. © 2008 Elsevier Inc. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Biochemical and Biophysical Research Communications | - |
dc.subject | Cancer | - |
dc.subject | Condensed tannin | - |
dc.subject | Fatty acid synthase | - |
dc.subject | Inhibition | - |
dc.title | Low concentration of condensed tannins from catechu significantly inhibits fatty acid synthase and growth of MCF-7 cells | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.bbrc.2008.04.062 | - |
dc.identifier.pmid | 18435908 | - |
dc.identifier.scopus | eid_2-s2.0-44149087821 | - |
dc.identifier.volume | 371 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 654 | - |
dc.identifier.epage | 658 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.isi | WOS:000256506600015 | - |
dc.identifier.issnl | 0006-291X | - |