File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1093/humupd/dmv037
- Scopus: eid_2-s2.0-84947609851
- PMID: 26231759
- WOS: WOS:000364766700007
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Cellular and molecular regulation of the activation of mammalian primordial follicles: Somatic cells initiate follicle activation in adulthood
Title | Cellular and molecular regulation of the activation of mammalian primordial follicles: Somatic cells initiate follicle activation in adulthood |
---|---|
Authors | |
Keywords | Primordial follicle activation KIT KIT ligand Mechanistic target of rapamycin complex 1 PI3 kinase signaling Primordial follicle granulosa cells |
Issue Date | 2015 |
Citation | Human Reproduction Update, 2015, v. 21, n. 6, p. 779-786 How to Cite? |
Abstract | © The Author 2015. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. BACKGROUND: The first small follicles to appear in the mammalian ovaries are primordial follicles. The initial pool of primordial follicles serves as the source of developing follicles and oocytes for the entire reproductive lifespan of the animal. Although the selective activation of primordial follicles is critical for female fertility, its underlying mechanisms have remained poorly understood. METHODS: A search of PubMed was conducted to identify peer-reviewed literature pertinent to the study of mammalian primordial follicle activation, especially recent reports of the role of primordial follicle granulosa cells (pfGCs) in regulating this process. RESULTS: In recent years, molecular mechanisms that regulate the activation of primordial follicles have been elucidated, mostly through the use of genetically modified mouse models. Several molecules and pathways operating in both the somatic pfGCs and oocytes, such as the phosphatidylinositol 3 kinase (PI3K) and the mechanistic target of rapamycin complex 1 (mTORC1) pathways, have been shown to be important for primordial follicle activation. More importantly, recent studies have provided an updated view of how exactly signaling pathways in pfGCs and in oocytes, such as the KIT ligand (KL) and KIT, coordinate in adult ovaries so that the activation of primordial follicles is achieved. CONCLUSIONS: In this review, we have provided an updated picture of how mammalian primordial follicles are activated. The functional roles of pfGCs in governing the activation of primordial follicles in adulthood are highlighted. The in-depth understanding of the cellular and molecular mechanisms of primordial follicle activation will hopefully lead to more treatments of female infertility, and the current progress indicates that the use of existing primordial follicles as a source for obtaining fertilizable oocytes as a new treatment for female infertility is just around the corner. |
Persistent Identifier | http://hdl.handle.net/10722/265679 |
ISSN | 2021 Impact Factor: 17.179 2020 SCImago Journal Rankings: 4.977 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhang, Hua | - |
dc.contributor.author | Liu, Kui | - |
dc.date.accessioned | 2018-12-03T01:21:21Z | - |
dc.date.available | 2018-12-03T01:21:21Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Human Reproduction Update, 2015, v. 21, n. 6, p. 779-786 | - |
dc.identifier.issn | 1355-4786 | - |
dc.identifier.uri | http://hdl.handle.net/10722/265679 | - |
dc.description.abstract | © The Author 2015. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. BACKGROUND: The first small follicles to appear in the mammalian ovaries are primordial follicles. The initial pool of primordial follicles serves as the source of developing follicles and oocytes for the entire reproductive lifespan of the animal. Although the selective activation of primordial follicles is critical for female fertility, its underlying mechanisms have remained poorly understood. METHODS: A search of PubMed was conducted to identify peer-reviewed literature pertinent to the study of mammalian primordial follicle activation, especially recent reports of the role of primordial follicle granulosa cells (pfGCs) in regulating this process. RESULTS: In recent years, molecular mechanisms that regulate the activation of primordial follicles have been elucidated, mostly through the use of genetically modified mouse models. Several molecules and pathways operating in both the somatic pfGCs and oocytes, such as the phosphatidylinositol 3 kinase (PI3K) and the mechanistic target of rapamycin complex 1 (mTORC1) pathways, have been shown to be important for primordial follicle activation. More importantly, recent studies have provided an updated view of how exactly signaling pathways in pfGCs and in oocytes, such as the KIT ligand (KL) and KIT, coordinate in adult ovaries so that the activation of primordial follicles is achieved. CONCLUSIONS: In this review, we have provided an updated picture of how mammalian primordial follicles are activated. The functional roles of pfGCs in governing the activation of primordial follicles in adulthood are highlighted. The in-depth understanding of the cellular and molecular mechanisms of primordial follicle activation will hopefully lead to more treatments of female infertility, and the current progress indicates that the use of existing primordial follicles as a source for obtaining fertilizable oocytes as a new treatment for female infertility is just around the corner. | - |
dc.language | eng | - |
dc.relation.ispartof | Human Reproduction Update | - |
dc.subject | Primordial follicle activation | - |
dc.subject | KIT | - |
dc.subject | KIT ligand | - |
dc.subject | Mechanistic target of rapamycin complex 1 | - |
dc.subject | PI3 kinase signaling | - |
dc.subject | Primordial follicle granulosa cells | - |
dc.title | Cellular and molecular regulation of the activation of mammalian primordial follicles: Somatic cells initiate follicle activation in adulthood | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1093/humupd/dmv037 | - |
dc.identifier.pmid | 26231759 | - |
dc.identifier.scopus | eid_2-s2.0-84947609851 | - |
dc.identifier.volume | 21 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 779 | - |
dc.identifier.epage | 786 | - |
dc.identifier.eissn | 1460-2369 | - |
dc.identifier.isi | WOS:000364766700007 | - |
dc.identifier.issnl | 1355-4786 | - |