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Article: MRI gradient-echo phase contrast of the brain at ultra-short TE with off-resonance saturation

TitleMRI gradient-echo phase contrast of the brain at ultra-short TE with off-resonance saturation
Authors
KeywordsPhase contrast
UTE – ultra-short TE
Brain
MRI – magnetic resonance imaging
Off-resonance saturation
Issue Date2018
Citation
NeuroImage, 2018, v. 175, p. 1-11 How to Cite?
Abstract© 2018 Larmor-frequency shift or image phase measured by gradient-echo sequences has provided a new source of MRI contrast. This contrast is being used to study both the structure and function of the brain. So far, phase images of the brain have been largely obtained at long echo times as maximum phase signal-to-noise ratio (SNR) is achieved at TE = T2* (∼40 ms at 3T). The structures of the brain, however, are compartmentalized and complex with a wide range of signal relaxation times. At such long TE, the short-T2 components are largely attenuated and contribute minimally to phase contrast. The purpose of this study was to determine whether proton gradient-echo images of the brain exhibit phase contrast at ultra-short TE (UTE). Our data showed that UTE images acquired at 7 T without off-resonance saturation do not contain significant phase contrast between gray and white matter. However, UTE images of the brain can attain strong phase contrast even at a nominal TE of 106 μs by using off-resonance RF saturation pulses, which provide direct saturation of ultra-short-T2 components and indirect saturation of longer-T2 components via magnetization transfer. In addition, phase contrast between gray and white matter acquired at UTE with off-resonance saturation is reversed compared to that of the long-T2 signals acquired at long TEs. This finding opens up a potential new way to manipulate image phase contrast of the brain. By accessing short and ultra-short-T2 species, MRI phase images may further improve the characterization of tissue microstructure in the brain.
Persistent Identifierhttp://hdl.handle.net/10722/265739
ISSN
2023 Impact Factor: 4.7
2023 SCImago Journal Rankings: 2.436
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWei, Hongjiang-
dc.contributor.authorCao, Peng-
dc.contributor.authorBischof, Antje-
dc.contributor.authorHenry, Roland G.-
dc.contributor.authorLarson, Peder E.Z.-
dc.contributor.authorLiu, Chunlei-
dc.date.accessioned2018-12-03T01:21:33Z-
dc.date.available2018-12-03T01:21:33Z-
dc.date.issued2018-
dc.identifier.citationNeuroImage, 2018, v. 175, p. 1-11-
dc.identifier.issn1053-8119-
dc.identifier.urihttp://hdl.handle.net/10722/265739-
dc.description.abstract© 2018 Larmor-frequency shift or image phase measured by gradient-echo sequences has provided a new source of MRI contrast. This contrast is being used to study both the structure and function of the brain. So far, phase images of the brain have been largely obtained at long echo times as maximum phase signal-to-noise ratio (SNR) is achieved at TE = T2* (∼40 ms at 3T). The structures of the brain, however, are compartmentalized and complex with a wide range of signal relaxation times. At such long TE, the short-T2 components are largely attenuated and contribute minimally to phase contrast. The purpose of this study was to determine whether proton gradient-echo images of the brain exhibit phase contrast at ultra-short TE (UTE). Our data showed that UTE images acquired at 7 T without off-resonance saturation do not contain significant phase contrast between gray and white matter. However, UTE images of the brain can attain strong phase contrast even at a nominal TE of 106 μs by using off-resonance RF saturation pulses, which provide direct saturation of ultra-short-T2 components and indirect saturation of longer-T2 components via magnetization transfer. In addition, phase contrast between gray and white matter acquired at UTE with off-resonance saturation is reversed compared to that of the long-T2 signals acquired at long TEs. This finding opens up a potential new way to manipulate image phase contrast of the brain. By accessing short and ultra-short-T2 species, MRI phase images may further improve the characterization of tissue microstructure in the brain.-
dc.languageeng-
dc.relation.ispartofNeuroImage-
dc.subjectPhase contrast-
dc.subjectUTE – ultra-short TE-
dc.subjectBrain-
dc.subjectMRI – magnetic resonance imaging-
dc.subjectOff-resonance saturation-
dc.titleMRI gradient-echo phase contrast of the brain at ultra-short TE with off-resonance saturation-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neuroimage.2018.03.066-
dc.identifier.scopuseid_2-s2.0-85044597105-
dc.identifier.volume175-
dc.identifier.spage1-
dc.identifier.epage11-
dc.identifier.eissn1095-9572-
dc.identifier.isiWOS:000432949000001-
dc.identifier.issnl1053-8119-

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