File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1259/0007-1285-68-807-331
- Scopus: eid_2-s2.0-0028923805
- PMID: 7735779
- WOS: WOS:A1995QN22500019
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Normal tissue injury after cancer therapy is a local response exacerbated by an endocrine effect of TGFβ
Title | Normal tissue injury after cancer therapy is a local response exacerbated by an endocrine effect of TGFβ |
---|---|
Authors | |
Issue Date | 1995 |
Citation | British Journal of Radiology, 1995, v. 68, n. 807, p. 331-333 How to Cite? |
Abstract | The sensitivity of normal tissues rather than of the tumour usually limits the effectiveness of cancer treatment. The normal tissue side effects from chemotherapy and/or radiotherapy result from both direct cellular loss and the extensive fibrosis that develops at the site of injury. Recent evidence suggests that the cytokine, transforming growth factor β (TGFβ), mediates this fibrogenic process. Herein, we provide evidence in support of the hypothesis that the fibrosis formation following therapy results not only from TGFβ produced locally in the injured normal tissue, but also from circulating TGFβ released by the tumour. Thus, therapy-induced normal tissue damage appears in part to be a local manifestation of a systemic condition. |
Persistent Identifier | http://hdl.handle.net/10722/266754 |
ISSN | 2023 Impact Factor: 1.8 2023 SCImago Journal Rankings: 0.812 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Anscher, M. S. | - |
dc.contributor.author | Kong, F. M. | - |
dc.contributor.author | Murase, T. | - |
dc.contributor.author | Jirtle, R. L. | - |
dc.date.accessioned | 2019-01-31T07:19:29Z | - |
dc.date.available | 2019-01-31T07:19:29Z | - |
dc.date.issued | 1995 | - |
dc.identifier.citation | British Journal of Radiology, 1995, v. 68, n. 807, p. 331-333 | - |
dc.identifier.issn | 0007-1285 | - |
dc.identifier.uri | http://hdl.handle.net/10722/266754 | - |
dc.description.abstract | The sensitivity of normal tissues rather than of the tumour usually limits the effectiveness of cancer treatment. The normal tissue side effects from chemotherapy and/or radiotherapy result from both direct cellular loss and the extensive fibrosis that develops at the site of injury. Recent evidence suggests that the cytokine, transforming growth factor β (TGFβ), mediates this fibrogenic process. Herein, we provide evidence in support of the hypothesis that the fibrosis formation following therapy results not only from TGFβ produced locally in the injured normal tissue, but also from circulating TGFβ released by the tumour. Thus, therapy-induced normal tissue damage appears in part to be a local manifestation of a systemic condition. | - |
dc.language | eng | - |
dc.relation.ispartof | British Journal of Radiology | - |
dc.title | Normal tissue injury after cancer therapy is a local response exacerbated by an endocrine effect of TGFβ | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1259/0007-1285-68-807-331 | - |
dc.identifier.pmid | 7735779 | - |
dc.identifier.scopus | eid_2-s2.0-0028923805 | - |
dc.identifier.volume | 68 | - |
dc.identifier.issue | 807 | - |
dc.identifier.spage | 331 | - |
dc.identifier.epage | 333 | - |
dc.identifier.isi | WOS:A1995QN22500019 | - |
dc.identifier.issnl | 0007-1285 | - |