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- Publisher Website: 10.1210/endo.136.10.7664647
- Scopus: eid_2-s2.0-0029121286
- PMID: 7664647
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Article: Bone morphogenetic protein-9 binds to liver cells and stimulates proliferation
Title | Bone morphogenetic protein-9 binds to liver cells and stimulates proliferation |
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Authors | |
Issue Date | 1995 |
Citation | Endocrinology, 1995, v. 136, n. 10, p. 4293-4297 How to Cite? |
Abstract | A new member of the transforming growth factor (TGF)-β superfamily, BMP-9, has recently been identified and shown to be expressed in the developing mouse liver. This report demonstrates that human HepG2 liver tumor cells bind recombinant human BMP-9 (rhBMP-9) with high affinity. Cross-linking analysis indicates that HepG2 cells express two BMP-9 receptors of approximately 54 and 80 kilodaltons, similar in size to the Type I and Type II receptors reported by others for TGF-β and BMP-4. However, cross-competition experiments demonstrate that the BMP-9 receptors on HepG2 cells do not bind other BMPs or TGF-β s, indicating that these are novel receptors with binding specificity for BMP-9. In functional studies, rhBMP-9 stimulates HepG2 cell proliferation as indicated by [3H]thymidine incorporation and cell counting assays. A proliferative effect of rh-BMP-9 was also observed on primary rat hepatocytes. In contrast, TGF-β had no effect on HepG2 cell proliferation and inhibited proliferation in primary hepatocytes. These results suggest that BMP-9, acting through a novel set of receptors, may play a regulatory role in hepatic growth and function. © 1995 by The Endocrine Society. |
Persistent Identifier | http://hdl.handle.net/10722/266756 |
ISSN | 2021 Impact Factor: 5.051 2020 SCImago Journal Rankings: 1.674 |
DC Field | Value | Language |
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dc.contributor.author | Song, Jeffrey J. | - |
dc.contributor.author | Celeste, Anthony J. | - |
dc.contributor.author | Kong, Feng Ming | - |
dc.contributor.author | Jirtle, Randy L. | - |
dc.contributor.author | Rosen, Vicki | - |
dc.contributor.author | Thies, R. Scott | - |
dc.date.accessioned | 2019-01-31T07:19:29Z | - |
dc.date.available | 2019-01-31T07:19:29Z | - |
dc.date.issued | 1995 | - |
dc.identifier.citation | Endocrinology, 1995, v. 136, n. 10, p. 4293-4297 | - |
dc.identifier.issn | 0013-7227 | - |
dc.identifier.uri | http://hdl.handle.net/10722/266756 | - |
dc.description.abstract | A new member of the transforming growth factor (TGF)-β superfamily, BMP-9, has recently been identified and shown to be expressed in the developing mouse liver. This report demonstrates that human HepG2 liver tumor cells bind recombinant human BMP-9 (rhBMP-9) with high affinity. Cross-linking analysis indicates that HepG2 cells express two BMP-9 receptors of approximately 54 and 80 kilodaltons, similar in size to the Type I and Type II receptors reported by others for TGF-β and BMP-4. However, cross-competition experiments demonstrate that the BMP-9 receptors on HepG2 cells do not bind other BMPs or TGF-β s, indicating that these are novel receptors with binding specificity for BMP-9. In functional studies, rhBMP-9 stimulates HepG2 cell proliferation as indicated by [3H]thymidine incorporation and cell counting assays. A proliferative effect of rh-BMP-9 was also observed on primary rat hepatocytes. In contrast, TGF-β had no effect on HepG2 cell proliferation and inhibited proliferation in primary hepatocytes. These results suggest that BMP-9, acting through a novel set of receptors, may play a regulatory role in hepatic growth and function. © 1995 by The Endocrine Society. | - |
dc.language | eng | - |
dc.relation.ispartof | Endocrinology | - |
dc.title | Bone morphogenetic protein-9 binds to liver cells and stimulates proliferation | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1210/endo.136.10.7664647 | - |
dc.identifier.pmid | 7664647 | - |
dc.identifier.scopus | eid_2-s2.0-0029121286 | - |
dc.identifier.volume | 136 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 4293 | - |
dc.identifier.epage | 4297 | - |
dc.identifier.eissn | 1945-7170 | - |
dc.identifier.issnl | 0013-7227 | - |