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- Publisher Website: 10.1016/j.athoracsur.2017.06.065
- Scopus: eid_2-s2.0-85032578501
- PMID: 29106887
- WOS: WOS:000415802000035
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Conference Paper: Patterns of Treatment and Outcomes for Definitive Therapy of Early Stage Non-Small Cell Lung Cancer
Title | Patterns of Treatment and Outcomes for Definitive Therapy of Early Stage Non-Small Cell Lung Cancer |
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Authors | |
Issue Date | 2017 |
Citation | Annals of Thoracic Surgery, 2017, v. 104, n. 6, p. 1881-1888 How to Cite? |
Abstract | © 2017 The Society of Thoracic Surgeons Background Definitive surgical and radiation therapy (RT) treatments are evolving rapidly for stage I non-small cell lung cancer (NSCLC). We hypothesized that utilization of definitive therapies increased between 2000 and 2010 and that survival improved for stage I NSCLC patients over the same time period. Secondary objectives were determining trends in patterns of care and predictors of utilization. Methods Population-based, observational, comparative effectiveness study used Surveillance, Epidemiology, and End Results-18 data from 2000 to 2010. The main outcome measure was 2-year risk of death for stage I NSCLC. Results Between 2000 and 2010, 40,589 patients (62%) underwent surgery, 10,048 (15%) received RT, 2,130 (3%) received both surgery and RT, and 11,537 (18%) received neither surgery nor RT. Annually, the odds of receiving either definitive RT or undergoing surgery increased relative to the odds of receiving no treatment (odds ratio [OR] radiation 1.04, 95% confidence interval [CI]: 1.03 to 1.05; OR surgery 1.05, 95% CI: 1.04 to 1.05). Among surgical patients, the proportion of sublobar resections steadily increased from 12.9% to 17.9%. For all patients, the 2-year risk of death decreased by 3.5% each year (hazard ratio [HR] 0.965, 95% CI: 0.962 to 0.969), driven primarily by improved survival for surgical (annualized HR 0.959, 95% CI: 0.954 to 0.964) and RT (annualized HR 0.942, 95% CI: 0.935 to 0.949) patients. Conclusions Between 2000 and 2010, stage I NSCLC patients were more likely to receive definitive treatment with either surgery or RT, leading to a decline in the number of untreated patients. Survival also improved substantially for stage I NSCLC patients, with the largest survival improvements observed in patients undergoing definitive RT. |
Persistent Identifier | http://hdl.handle.net/10722/266808 |
ISSN | 2023 Impact Factor: 3.6 2023 SCImago Journal Rankings: 1.203 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Kapadia, Nirav S. | - |
dc.contributor.author | Valle, Luca F. | - |
dc.contributor.author | George, Julie A. | - |
dc.contributor.author | Jagsi, Reshma | - |
dc.contributor.author | D'Amico, Thomas A. | - |
dc.contributor.author | Dexter, Elisabeth U. | - |
dc.contributor.author | Vigneau, Fawn D. | - |
dc.contributor.author | Kong, Feng Ming | - |
dc.date.accessioned | 2019-01-31T07:19:39Z | - |
dc.date.available | 2019-01-31T07:19:39Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Annals of Thoracic Surgery, 2017, v. 104, n. 6, p. 1881-1888 | - |
dc.identifier.issn | 0003-4975 | - |
dc.identifier.uri | http://hdl.handle.net/10722/266808 | - |
dc.description.abstract | © 2017 The Society of Thoracic Surgeons Background Definitive surgical and radiation therapy (RT) treatments are evolving rapidly for stage I non-small cell lung cancer (NSCLC). We hypothesized that utilization of definitive therapies increased between 2000 and 2010 and that survival improved for stage I NSCLC patients over the same time period. Secondary objectives were determining trends in patterns of care and predictors of utilization. Methods Population-based, observational, comparative effectiveness study used Surveillance, Epidemiology, and End Results-18 data from 2000 to 2010. The main outcome measure was 2-year risk of death for stage I NSCLC. Results Between 2000 and 2010, 40,589 patients (62%) underwent surgery, 10,048 (15%) received RT, 2,130 (3%) received both surgery and RT, and 11,537 (18%) received neither surgery nor RT. Annually, the odds of receiving either definitive RT or undergoing surgery increased relative to the odds of receiving no treatment (odds ratio [OR] radiation 1.04, 95% confidence interval [CI]: 1.03 to 1.05; OR surgery 1.05, 95% CI: 1.04 to 1.05). Among surgical patients, the proportion of sublobar resections steadily increased from 12.9% to 17.9%. For all patients, the 2-year risk of death decreased by 3.5% each year (hazard ratio [HR] 0.965, 95% CI: 0.962 to 0.969), driven primarily by improved survival for surgical (annualized HR 0.959, 95% CI: 0.954 to 0.964) and RT (annualized HR 0.942, 95% CI: 0.935 to 0.949) patients. Conclusions Between 2000 and 2010, stage I NSCLC patients were more likely to receive definitive treatment with either surgery or RT, leading to a decline in the number of untreated patients. Survival also improved substantially for stage I NSCLC patients, with the largest survival improvements observed in patients undergoing definitive RT. | - |
dc.language | eng | - |
dc.relation.ispartof | Annals of Thoracic Surgery | - |
dc.title | Patterns of Treatment and Outcomes for Definitive Therapy of Early Stage Non-Small Cell Lung Cancer | - |
dc.type | Conference_Paper | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.athoracsur.2017.06.065 | - |
dc.identifier.pmid | 29106887 | - |
dc.identifier.scopus | eid_2-s2.0-85032578501 | - |
dc.identifier.volume | 104 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 1881 | - |
dc.identifier.epage | 1888 | - |
dc.identifier.eissn | 1552-6259 | - |
dc.identifier.isi | WOS:000415802000035 | - |
dc.identifier.issnl | 0003-4975 | - |