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Article: High-dose radiation improved local tumor control and overall survival in patients with inoperable/unresectable non-small-cell lung cancer: Long-term results of a radiation dose escalation study

TitleHigh-dose radiation improved local tumor control and overall survival in patients with inoperable/unresectable non-small-cell lung cancer: Long-term results of a radiation dose escalation study
Authors
KeywordsHigh dose
Local control
Non-small-cell lung cancer
Survival
Three-dimensional conformal radiation therapy
Issue Date2005
Citation
International Journal of Radiation Oncology Biology Physics, 2005, v. 63, n. 2, p. 324-333 How to Cite?
AbstractPurpose: To determine whether high-dose radiation leads to improved outcomes in patients with non-small-cell lung cancer (NSCLC). Methods and Materials: This analysis included 106 patients with newly diagnosed or recurrent Stages I-III NSCLC, treated with 63-103 Gy in 2.1-Gy fractions, using three-dimensional conformal radiation therapy (3D-CRT) per a dose escalation trial. Targets included the primary tumor and any lymph nodes <1 cm, without intentionally including negative nodal regions. Nineteen percent of patients (20/106) received neoadjuvant chemotherapy. Patient, tumor, and treatment factors were evaluated for association with outcomes. Estimated median follow-up was 8.5 years. Results: Median survival was 19 months, and 5-year overall survival (OS) was 13%. Multivariate analysis revealed weight loss (p = 0.011) and radiation dose (p = 0.0006) were significant predictors for OS. The 5-year OS was 4%, 22%, and 28% for patients receiving 63-69, 74-84, and 92-103 Gy, respectively. Although presence of nodal disease was negatively associated with locoregional control under univariate analysis, radiation dose was the only significant predictor when multiple variables were included (p = 0.015). The 5-year control rate was 12%, 35%, and 49% for 63-69, 74-84, and 92-103 Gy, respectively. Conclusions: Higher dose radiation is associated with improved outcomes in patients with NSCLC treated in the range of 63-103 Gy. © 2005 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/266844
ISSN
2020 Impact Factor: 7.038
2020 SCImago Journal Rankings: 2.117
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKong, Feng Ming-
dc.contributor.authorTen Haken, Randall K.-
dc.contributor.authorSchipper, Matthew J.-
dc.contributor.authorSullivan, Molly A.-
dc.contributor.authorChen, Ming-
dc.contributor.authorLopez, Carlos-
dc.contributor.authorKalemkerian, Gregory P.-
dc.contributor.authorHayman, James A.-
dc.date.accessioned2019-01-31T07:19:46Z-
dc.date.available2019-01-31T07:19:46Z-
dc.date.issued2005-
dc.identifier.citationInternational Journal of Radiation Oncology Biology Physics, 2005, v. 63, n. 2, p. 324-333-
dc.identifier.issn0360-3016-
dc.identifier.urihttp://hdl.handle.net/10722/266844-
dc.description.abstractPurpose: To determine whether high-dose radiation leads to improved outcomes in patients with non-small-cell lung cancer (NSCLC). Methods and Materials: This analysis included 106 patients with newly diagnosed or recurrent Stages I-III NSCLC, treated with 63-103 Gy in 2.1-Gy fractions, using three-dimensional conformal radiation therapy (3D-CRT) per a dose escalation trial. Targets included the primary tumor and any lymph nodes <1 cm, without intentionally including negative nodal regions. Nineteen percent of patients (20/106) received neoadjuvant chemotherapy. Patient, tumor, and treatment factors were evaluated for association with outcomes. Estimated median follow-up was 8.5 years. Results: Median survival was 19 months, and 5-year overall survival (OS) was 13%. Multivariate analysis revealed weight loss (p = 0.011) and radiation dose (p = 0.0006) were significant predictors for OS. The 5-year OS was 4%, 22%, and 28% for patients receiving 63-69, 74-84, and 92-103 Gy, respectively. Although presence of nodal disease was negatively associated with locoregional control under univariate analysis, radiation dose was the only significant predictor when multiple variables were included (p = 0.015). The 5-year control rate was 12%, 35%, and 49% for 63-69, 74-84, and 92-103 Gy, respectively. Conclusions: Higher dose radiation is associated with improved outcomes in patients with NSCLC treated in the range of 63-103 Gy. © 2005 Elsevier Inc.-
dc.languageeng-
dc.relation.ispartofInternational Journal of Radiation Oncology Biology Physics-
dc.subjectHigh dose-
dc.subjectLocal control-
dc.subjectNon-small-cell lung cancer-
dc.subjectSurvival-
dc.subjectThree-dimensional conformal radiation therapy-
dc.titleHigh-dose radiation improved local tumor control and overall survival in patients with inoperable/unresectable non-small-cell lung cancer: Long-term results of a radiation dose escalation study-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijrobp.2005.02.010-
dc.identifier.pmid16168827-
dc.identifier.scopuseid_2-s2.0-24944432301-
dc.identifier.volume63-
dc.identifier.issue2-
dc.identifier.spage324-
dc.identifier.epage333-
dc.identifier.isiWOS:000232083700003-
dc.identifier.issnl0360-3016-

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