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- Publisher Website: 10.1016/j.ijrobp.2005.02.010
- Scopus: eid_2-s2.0-24944432301
- PMID: 16168827
- WOS: WOS:000232083700003
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Article: High-dose radiation improved local tumor control and overall survival in patients with inoperable/unresectable non-small-cell lung cancer: Long-term results of a radiation dose escalation study
Title | High-dose radiation improved local tumor control and overall survival in patients with inoperable/unresectable non-small-cell lung cancer: Long-term results of a radiation dose escalation study |
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Authors | |
Keywords | High dose Local control Non-small-cell lung cancer Survival Three-dimensional conformal radiation therapy |
Issue Date | 2005 |
Citation | International Journal of Radiation Oncology Biology Physics, 2005, v. 63, n. 2, p. 324-333 How to Cite? |
Abstract | Purpose: To determine whether high-dose radiation leads to improved outcomes in patients with non-small-cell lung cancer (NSCLC). Methods and Materials: This analysis included 106 patients with newly diagnosed or recurrent Stages I-III NSCLC, treated with 63-103 Gy in 2.1-Gy fractions, using three-dimensional conformal radiation therapy (3D-CRT) per a dose escalation trial. Targets included the primary tumor and any lymph nodes <1 cm, without intentionally including negative nodal regions. Nineteen percent of patients (20/106) received neoadjuvant chemotherapy. Patient, tumor, and treatment factors were evaluated for association with outcomes. Estimated median follow-up was 8.5 years. Results: Median survival was 19 months, and 5-year overall survival (OS) was 13%. Multivariate analysis revealed weight loss (p = 0.011) and radiation dose (p = 0.0006) were significant predictors for OS. The 5-year OS was 4%, 22%, and 28% for patients receiving 63-69, 74-84, and 92-103 Gy, respectively. Although presence of nodal disease was negatively associated with locoregional control under univariate analysis, radiation dose was the only significant predictor when multiple variables were included (p = 0.015). The 5-year control rate was 12%, 35%, and 49% for 63-69, 74-84, and 92-103 Gy, respectively. Conclusions: Higher dose radiation is associated with improved outcomes in patients with NSCLC treated in the range of 63-103 Gy. © 2005 Elsevier Inc. |
Persistent Identifier | http://hdl.handle.net/10722/266844 |
ISSN | 2023 Impact Factor: 6.4 2023 SCImago Journal Rankings: 1.992 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Kong, Feng Ming | - |
dc.contributor.author | Ten Haken, Randall K. | - |
dc.contributor.author | Schipper, Matthew J. | - |
dc.contributor.author | Sullivan, Molly A. | - |
dc.contributor.author | Chen, Ming | - |
dc.contributor.author | Lopez, Carlos | - |
dc.contributor.author | Kalemkerian, Gregory P. | - |
dc.contributor.author | Hayman, James A. | - |
dc.date.accessioned | 2019-01-31T07:19:46Z | - |
dc.date.available | 2019-01-31T07:19:46Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | International Journal of Radiation Oncology Biology Physics, 2005, v. 63, n. 2, p. 324-333 | - |
dc.identifier.issn | 0360-3016 | - |
dc.identifier.uri | http://hdl.handle.net/10722/266844 | - |
dc.description.abstract | Purpose: To determine whether high-dose radiation leads to improved outcomes in patients with non-small-cell lung cancer (NSCLC). Methods and Materials: This analysis included 106 patients with newly diagnosed or recurrent Stages I-III NSCLC, treated with 63-103 Gy in 2.1-Gy fractions, using three-dimensional conformal radiation therapy (3D-CRT) per a dose escalation trial. Targets included the primary tumor and any lymph nodes <1 cm, without intentionally including negative nodal regions. Nineteen percent of patients (20/106) received neoadjuvant chemotherapy. Patient, tumor, and treatment factors were evaluated for association with outcomes. Estimated median follow-up was 8.5 years. Results: Median survival was 19 months, and 5-year overall survival (OS) was 13%. Multivariate analysis revealed weight loss (p = 0.011) and radiation dose (p = 0.0006) were significant predictors for OS. The 5-year OS was 4%, 22%, and 28% for patients receiving 63-69, 74-84, and 92-103 Gy, respectively. Although presence of nodal disease was negatively associated with locoregional control under univariate analysis, radiation dose was the only significant predictor when multiple variables were included (p = 0.015). The 5-year control rate was 12%, 35%, and 49% for 63-69, 74-84, and 92-103 Gy, respectively. Conclusions: Higher dose radiation is associated with improved outcomes in patients with NSCLC treated in the range of 63-103 Gy. © 2005 Elsevier Inc. | - |
dc.language | eng | - |
dc.relation.ispartof | International Journal of Radiation Oncology Biology Physics | - |
dc.subject | High dose | - |
dc.subject | Local control | - |
dc.subject | Non-small-cell lung cancer | - |
dc.subject | Survival | - |
dc.subject | Three-dimensional conformal radiation therapy | - |
dc.title | High-dose radiation improved local tumor control and overall survival in patients with inoperable/unresectable non-small-cell lung cancer: Long-term results of a radiation dose escalation study | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.ijrobp.2005.02.010 | - |
dc.identifier.pmid | 16168827 | - |
dc.identifier.scopus | eid_2-s2.0-24944432301 | - |
dc.identifier.volume | 63 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 324 | - |
dc.identifier.epage | 333 | - |
dc.identifier.isi | WOS:000232083700003 | - |
dc.identifier.issnl | 0360-3016 | - |