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Article: Using 18F-Fluorodeoxyglucose Positron Emission Tomography to Estimate the Length of Gross Tumor in Patients With Squamous Cell Carcinoma of the Esophagus

TitleUsing 18F-Fluorodeoxyglucose Positron Emission Tomography to Estimate the Length of Gross Tumor in Patients With Squamous Cell Carcinoma of the Esophagus
Authors
KeywordsEsophageal carcinoma
Positron emission tomography
Radiotherapy
Issue Date2009
Citation
International Journal of Radiation Oncology Biology Physics, 2009, v. 73, n. 1, p. 136-141 How to Cite?
AbstractPurpose: To determine the optimal method of using18F-fluorodeoxyglucose positron emission tomography (FDG-PET) to estimate gross tumor length in esophageal carcinoma. Methods and Materials: Thirty-six patients with esophageal squamous cell carcinoma treated with radical surgery were enrolled. Gross tumor volumes (GTVs) were delineated using three different methods: visual interpretation, standardized uptake value (SUV) 2.5, and 40% of maximum standard uptake value (SUVmax) on FDG-PET imaging. The length of tumors on PET scan were measured and recorded as Lengthvis, Length2.5, and Length40, respectively, and compared with the length of gross tumor in the resected specimen (Lengthgross). All PET data were reviewed again postoperatively, and the GTV was delineated using various percentages of SUVmax. The optimal-threshold SUV was generated when the length of PET matched the Lengthgross. Results: The mean (±SD) Lengthgrosswas 5.48 ± 1.98 cm. The mean Lengthvis, Length2.5, and Length40were 5.18 ± 1.93 cm, 5.49 ± 1.79 cm, and 4.34 ± 1.54 cm, respectively. The mean Lengthvis(p = 0.123) and Length2.5(p = 0.957) were not significantly different from Lengthgross, and Length2.5seems more approximate to Lengthgross.The mean Length40was significantly shorter than Lengthgross(p < 0.001). The mean optimal threshold was 23.81% ± 11.29% for all tumors, and it was 19.78% ± 8.59%, 30.92% ± 12.28% for tumors ≥5 cm, and <5 cm, respectively (p = 0.009). The correlation coefficients of the optimal threshold were -0.802 and -0.561 with SUVmaxand Lengthgross, respectively. Conclusions: The optimal PET method to estimate the length of gross tumor varies with tumor length and SUVmax; an SUV cutoff of 2.5 provided the closest estimation in this study. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/266890
ISSN
2023 Impact Factor: 6.4
2023 SCImago Journal Rankings: 1.992
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhong, Xiaojun-
dc.contributor.authorYu, Jinming-
dc.contributor.authorZhang, Baijiang-
dc.contributor.authorMu, Dianbin-
dc.contributor.authorZhang, Weidi-
dc.contributor.authorLi, Daotang-
dc.contributor.authorHan, Anqin-
dc.contributor.authorSong, Pingping-
dc.contributor.authorLi, Hui-
dc.contributor.authorYang, Guoren-
dc.contributor.authorKong, Feng Ming-
dc.contributor.authorFu, Zheng-
dc.date.accessioned2019-01-31T07:19:54Z-
dc.date.available2019-01-31T07:19:54Z-
dc.date.issued2009-
dc.identifier.citationInternational Journal of Radiation Oncology Biology Physics, 2009, v. 73, n. 1, p. 136-141-
dc.identifier.issn0360-3016-
dc.identifier.urihttp://hdl.handle.net/10722/266890-
dc.description.abstractPurpose: To determine the optimal method of using18F-fluorodeoxyglucose positron emission tomography (FDG-PET) to estimate gross tumor length in esophageal carcinoma. Methods and Materials: Thirty-six patients with esophageal squamous cell carcinoma treated with radical surgery were enrolled. Gross tumor volumes (GTVs) were delineated using three different methods: visual interpretation, standardized uptake value (SUV) 2.5, and 40% of maximum standard uptake value (SUVmax) on FDG-PET imaging. The length of tumors on PET scan were measured and recorded as Lengthvis, Length2.5, and Length40, respectively, and compared with the length of gross tumor in the resected specimen (Lengthgross). All PET data were reviewed again postoperatively, and the GTV was delineated using various percentages of SUVmax. The optimal-threshold SUV was generated when the length of PET matched the Lengthgross. Results: The mean (±SD) Lengthgrosswas 5.48 ± 1.98 cm. The mean Lengthvis, Length2.5, and Length40were 5.18 ± 1.93 cm, 5.49 ± 1.79 cm, and 4.34 ± 1.54 cm, respectively. The mean Lengthvis(p = 0.123) and Length2.5(p = 0.957) were not significantly different from Lengthgross, and Length2.5seems more approximate to Lengthgross.The mean Length40was significantly shorter than Lengthgross(p < 0.001). The mean optimal threshold was 23.81% ± 11.29% for all tumors, and it was 19.78% ± 8.59%, 30.92% ± 12.28% for tumors ≥5 cm, and <5 cm, respectively (p = 0.009). The correlation coefficients of the optimal threshold were -0.802 and -0.561 with SUVmaxand Lengthgross, respectively. Conclusions: The optimal PET method to estimate the length of gross tumor varies with tumor length and SUVmax; an SUV cutoff of 2.5 provided the closest estimation in this study. © 2009 Elsevier Inc. All rights reserved.-
dc.languageeng-
dc.relation.ispartofInternational Journal of Radiation Oncology Biology Physics-
dc.subjectEsophageal carcinoma-
dc.subjectPositron emission tomography-
dc.subjectRadiotherapy-
dc.titleUsing 18F-Fluorodeoxyglucose Positron Emission Tomography to Estimate the Length of Gross Tumor in Patients With Squamous Cell Carcinoma of the Esophagus-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijrobp.2008.04.015-
dc.identifier.pmid18538492-
dc.identifier.scopuseid_2-s2.0-57649112364-
dc.identifier.volume73-
dc.identifier.issue1-
dc.identifier.spage136-
dc.identifier.epage141-
dc.identifier.isiWOS:000261820200021-
dc.identifier.issnl0360-3016-

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