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Article: Impact of Fraction Size on Lung Radiation Toxicity: Hypofractionation may be Beneficial in Dose Escalation of Radiotherapy for Lung Cancers

TitleImpact of Fraction Size on Lung Radiation Toxicity: Hypofractionation may be Beneficial in Dose Escalation of Radiotherapy for Lung Cancers
Authors
KeywordsRadiobiology
Stereotactic body radiotherapy
Hypofraction
Non-small-cell lung cancer
Normal tissue complication probability
Issue Date2010
Citation
International Journal of Radiation Oncology Biology Physics, 2010, v. 76, n. 3, p. 782-788 How to Cite?
AbstractPurpose: To assess how fraction size impacts lung radiation toxicity and therapeutic ratio in treatment of lung cancers. Methods and Materials: The relative damaged volume (RDV) of lung was used as the endpoint in the comparison of various fractionation schemes with the same normalized total dose (NTD) to the tumor. The RDV was computed from the biologically corrected lung dose-volume histogram (DVH), with an α/β ratio of 3 and 10 for lung and tumor, respectively. Two different (linear and S-shaped) local dose-effect models that incorporated the concept of a threshold dose effect with a single parameter DL50 (dose at 50% local dose effect) were used to convert the DVH into the RDV. The comparison was conducted using four representative DVHs at different NTD and DL50 values. Results: The RDV decreased with increasing dose/fraction when the NTD was larger than a critical dose (DCR) and increased when the NTD was less than DCR. The DCR was 32-50 Gy and 58-87 Gy for a small tumor (11 cm3) for the linear and S-shaped local dose-effect models, respectively, when DL50 was 20-30 Gy. The DCR was 66-97 Gy and 66-99 Gy, respectively, for a large tumor (266 cm3). Hypofractionation was preferred for small tumors and higher NTDs, and conventional fractionation was better for large tumors and lower NTDs. Hypofractionation might be beneficial for intermediate-sized tumors when NTD = 80-90 Gy, especially if the DL50 is small (20 Gy). Conclusion: This computational study demonstrated that hypofractionated stereotactic body radiotherapy is a better regimen than conventional fractionation in lung cancer patients with small tumors and high doses, because it generates lower RDV when the tumor NTD is kept unchanged. © 2010 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/266903
ISSN
2023 Impact Factor: 6.4
2023 SCImago Journal Rankings: 1.992
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJin, Jin Yue-
dc.contributor.authorKong, Feng Ming-
dc.contributor.authorChetty, Indrin J.-
dc.contributor.authorAjlouni, Munther-
dc.contributor.authorRyu, Samuel-
dc.contributor.authorTen Haken, Randall-
dc.contributor.authorMovsas, Benjamin-
dc.date.accessioned2019-01-31T07:19:56Z-
dc.date.available2019-01-31T07:19:56Z-
dc.date.issued2010-
dc.identifier.citationInternational Journal of Radiation Oncology Biology Physics, 2010, v. 76, n. 3, p. 782-788-
dc.identifier.issn0360-3016-
dc.identifier.urihttp://hdl.handle.net/10722/266903-
dc.description.abstractPurpose: To assess how fraction size impacts lung radiation toxicity and therapeutic ratio in treatment of lung cancers. Methods and Materials: The relative damaged volume (RDV) of lung was used as the endpoint in the comparison of various fractionation schemes with the same normalized total dose (NTD) to the tumor. The RDV was computed from the biologically corrected lung dose-volume histogram (DVH), with an α/β ratio of 3 and 10 for lung and tumor, respectively. Two different (linear and S-shaped) local dose-effect models that incorporated the concept of a threshold dose effect with a single parameter DL50 (dose at 50% local dose effect) were used to convert the DVH into the RDV. The comparison was conducted using four representative DVHs at different NTD and DL50 values. Results: The RDV decreased with increasing dose/fraction when the NTD was larger than a critical dose (DCR) and increased when the NTD was less than DCR. The DCR was 32-50 Gy and 58-87 Gy for a small tumor (11 cm3) for the linear and S-shaped local dose-effect models, respectively, when DL50 was 20-30 Gy. The DCR was 66-97 Gy and 66-99 Gy, respectively, for a large tumor (266 cm3). Hypofractionation was preferred for small tumors and higher NTDs, and conventional fractionation was better for large tumors and lower NTDs. Hypofractionation might be beneficial for intermediate-sized tumors when NTD = 80-90 Gy, especially if the DL50 is small (20 Gy). Conclusion: This computational study demonstrated that hypofractionated stereotactic body radiotherapy is a better regimen than conventional fractionation in lung cancer patients with small tumors and high doses, because it generates lower RDV when the tumor NTD is kept unchanged. © 2010 Elsevier Inc. All rights reserved.-
dc.languageeng-
dc.relation.ispartofInternational Journal of Radiation Oncology Biology Physics-
dc.subjectRadiobiology-
dc.subjectStereotactic body radiotherapy-
dc.subjectHypofraction-
dc.subjectNon-small-cell lung cancer-
dc.subjectNormal tissue complication probability-
dc.titleImpact of Fraction Size on Lung Radiation Toxicity: Hypofractionation may be Beneficial in Dose Escalation of Radiotherapy for Lung Cancers-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijrobp.2009.02.079-
dc.identifier.pmid19577855-
dc.identifier.scopuseid_2-s2.0-76049093691-
dc.identifier.volume76-
dc.identifier.issue3-
dc.identifier.spage782-
dc.identifier.epage788-
dc.identifier.isiWOS:000275072200018-
dc.identifier.issnl0360-3016-

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