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Article: Semiquantification and classification of local pulmonary function by V/Q single photon emission computed tomography in patients with non-small cell lung cancer: Potential indication for radiotherapy planning

TitleSemiquantification and classification of local pulmonary function by V/Q single photon emission computed tomography in patients with non-small cell lung cancer: Potential indication for radiotherapy planning
Authors
KeywordsSingle photon emission computerized tomography
Radiotherapy
Non-small cell lung cancer
Ventilation
Perfusion
Issue Date2011
Citation
Journal of Thoracic Oncology, 2011, v. 6, n. 1, p. 71-78 How to Cite?
AbstractINTRODUCTION: Perfusion (Q) single photon emission computed tomography (SPECT) has been used to divert dose away from higher-functioning lung during radiation therapy (RT) planning. This study aimed to (1) study regional lung function through coregistered pulmonary ventilation/perfusion (V/Q)-SPECT-CT and (2) classify these defects for its potential value in radiation planning in patients with non-small cell lung cancer (NSCLC). METHODS: Patients with stages I to III NSCLC requiring radiation-based therapy were eligible for this prospective study. V/Q-SPECT performed within 2 weeks before the start of radiation was interpreted by nuclear medicine physicians and then measured by a semiquantitative score. The potential mechanism of V and Q defects was analyzed; the potential impact of V/Q-SPECT over Q-SPECT alone was completed through classified applications (high-dose RT versus RT avoidance) during planning. RESULTS: Images of 51 consecutive patients were analyzed. The V and Q defects were matched, reverse mismatched (V defect > Q defect), and mismatched (Q defect > V defect) in 61, 31, and 8% of patients, respectively. Tumor was the leading cause of the defects of ipsilateral lung in 73% of patients. The defect scores of the ipsilateral lung were greater in patients with central primaries than those with peripheral primaries for both V-SPECT (2.3 ± 1.1 versus 1.5 ± 0.8, p = 0.017) and Q-SPECT (2.2 ± 0.8 versus 1.4 ± 0.6, p = 0.000). The patients with chronic obstructive pulmonary disease had greater defect scores in contralateral lung for both V-SPECT (1.5 ± 0.7 versus 1.0 ± 0.8, p = 0.006) and Q-SPECT (1.4 ± 0.6 versus 1.0 ± 0.4, p = 0.010). On assessing the potential value of SPECT on RT plan, 39% of patients could have their RT plan when applying V/Q-SPECT rather than Q-SPECT alone. CONCLUSIONS: V/Q-SPECT provides a more comprehensive functional assessment, may provide additional value over Q-SPECT alone in assessing local pulmonary function, and guide RT plan decisions in patients with NSCLC. Copyright © 2010 by the international Association fot the Study of lung Cancer.
Persistent Identifierhttp://hdl.handle.net/10722/266917
ISSN
2020 Impact Factor: 15.609
2020 SCImago Journal Rankings: 4.539
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYuan, Shuanghu-
dc.contributor.authorFrey, Kirk A.-
dc.contributor.authorGross, Milton D.-
dc.contributor.authorHayman, James A.-
dc.contributor.authorArenberg, Doug-
dc.contributor.authorCurtis, Jeffrey L.-
dc.contributor.authorCai, Xu Wei-
dc.contributor.authorRamnath, Nithya-
dc.contributor.authorKalemkerian, Gregory P.-
dc.contributor.authorTen Haken, Randall K.-
dc.contributor.authorEisbruch, Avraham-
dc.contributor.authorKong, Feng Ming-
dc.date.accessioned2019-01-31T07:19:58Z-
dc.date.available2019-01-31T07:19:58Z-
dc.date.issued2011-
dc.identifier.citationJournal of Thoracic Oncology, 2011, v. 6, n. 1, p. 71-78-
dc.identifier.issn1556-0864-
dc.identifier.urihttp://hdl.handle.net/10722/266917-
dc.description.abstractINTRODUCTION: Perfusion (Q) single photon emission computed tomography (SPECT) has been used to divert dose away from higher-functioning lung during radiation therapy (RT) planning. This study aimed to (1) study regional lung function through coregistered pulmonary ventilation/perfusion (V/Q)-SPECT-CT and (2) classify these defects for its potential value in radiation planning in patients with non-small cell lung cancer (NSCLC). METHODS: Patients with stages I to III NSCLC requiring radiation-based therapy were eligible for this prospective study. V/Q-SPECT performed within 2 weeks before the start of radiation was interpreted by nuclear medicine physicians and then measured by a semiquantitative score. The potential mechanism of V and Q defects was analyzed; the potential impact of V/Q-SPECT over Q-SPECT alone was completed through classified applications (high-dose RT versus RT avoidance) during planning. RESULTS: Images of 51 consecutive patients were analyzed. The V and Q defects were matched, reverse mismatched (V defect > Q defect), and mismatched (Q defect > V defect) in 61, 31, and 8% of patients, respectively. Tumor was the leading cause of the defects of ipsilateral lung in 73% of patients. The defect scores of the ipsilateral lung were greater in patients with central primaries than those with peripheral primaries for both V-SPECT (2.3 ± 1.1 versus 1.5 ± 0.8, p = 0.017) and Q-SPECT (2.2 ± 0.8 versus 1.4 ± 0.6, p = 0.000). The patients with chronic obstructive pulmonary disease had greater defect scores in contralateral lung for both V-SPECT (1.5 ± 0.7 versus 1.0 ± 0.8, p = 0.006) and Q-SPECT (1.4 ± 0.6 versus 1.0 ± 0.4, p = 0.010). On assessing the potential value of SPECT on RT plan, 39% of patients could have their RT plan when applying V/Q-SPECT rather than Q-SPECT alone. CONCLUSIONS: V/Q-SPECT provides a more comprehensive functional assessment, may provide additional value over Q-SPECT alone in assessing local pulmonary function, and guide RT plan decisions in patients with NSCLC. Copyright © 2010 by the international Association fot the Study of lung Cancer.-
dc.languageeng-
dc.relation.ispartofJournal of Thoracic Oncology-
dc.subjectSingle photon emission computerized tomography-
dc.subjectRadiotherapy-
dc.subjectNon-small cell lung cancer-
dc.subjectVentilation-
dc.subjectPerfusion-
dc.titleSemiquantification and classification of local pulmonary function by V/Q single photon emission computed tomography in patients with non-small cell lung cancer: Potential indication for radiotherapy planning-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1097/JTO.0b013e3181f77b40-
dc.identifier.scopuseid_2-s2.0-78651080860-
dc.identifier.volume6-
dc.identifier.issue1-
dc.identifier.spage71-
dc.identifier.epage78-
dc.identifier.eissn1556-1380-
dc.identifier.isiWOS:000285587800014-
dc.identifier.issnl1556-0864-

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