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Article: Poor baseline pulmonary function may not increase the risk of radiation-induced lung toxicity

TitlePoor baseline pulmonary function may not increase the risk of radiation-induced lung toxicity
Authors
Issue Date2013
Citation
International Journal of Radiation Oncology Biology Physics, 2013, v. 85, n. 3, p. 798-804 How to Cite?
AbstractPurpose: Poor pulmonary function (PF) is often considered a contraindication to definitive radiation therapy for lung cancer. This study investigated whether baseline PF was associated with radiation-induced lung toxicity (RILT) in patients with non-small cell lung cancer (NSCLC) receiving conformal radiation therapy (CRT). Methods and Materials: NSCLC patients treated with CRT and tested for PF at baseline were eligible. Baseline predicted values of forced expiratory volume in 1 sec (FEV1), forced vital capacity (FVC), and diffusion capacity of lung for carbon monoxide (DLCO) were analyzed. Additional factors included age, gender, smoking status, Karnofsky performance status, coexisting chronic obstructive pulmonary disease (COPD), tumor location, histology, concurrent chemotherapy, radiation dose, and mean lung dose (MLD) were evaluated for RILT. The primary endpoint was symptomatic RILT (SRILT), including grade ≥2 radiation pneumonitis and fibrosis. Results: There was a total of 260 patients, and SRILT occurred in 58 (22.3%) of them. Mean FEV1 values for SRILT and non-SRILT patients were 71.7% and 65.9% (P=.077). Under univariate analysis, risk of SRILT increased with MLD (P=.008), the absence of COPD (P=.047), and FEV1 (P=.077). Age (65 split) and MLD were significantly associated with SRILT in multivariate analysis. The addition of FEV1 and age with the MLD-based model slightly improved the predictability of SRILT (area under curve from 0.63-0.70, P=.088). Conclusions: Poor baseline PF does not increase the risk of SRILT, and combining FEV1, age, and MLD may improve the predictive ability. © 2013 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/266953
ISSN
2020 Impact Factor: 7.038
2020 SCImago Journal Rankings: 2.117
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, Jingbo-
dc.contributor.authorCao, Jianzhong-
dc.contributor.authorYuan, Shuanghu-
dc.contributor.authorJi, Wei-
dc.contributor.authorArenberg, Douglas-
dc.contributor.authorDai, Jianrong-
dc.contributor.authorStanton, Paul-
dc.contributor.authorTatro, Daniel-
dc.contributor.authorTen Haken, Randall K.-
dc.contributor.authorWang, Luhua-
dc.contributor.authorKong, Feng Ming-
dc.date.accessioned2019-01-31T07:20:05Z-
dc.date.available2019-01-31T07:20:05Z-
dc.date.issued2013-
dc.identifier.citationInternational Journal of Radiation Oncology Biology Physics, 2013, v. 85, n. 3, p. 798-804-
dc.identifier.issn0360-3016-
dc.identifier.urihttp://hdl.handle.net/10722/266953-
dc.description.abstractPurpose: Poor pulmonary function (PF) is often considered a contraindication to definitive radiation therapy for lung cancer. This study investigated whether baseline PF was associated with radiation-induced lung toxicity (RILT) in patients with non-small cell lung cancer (NSCLC) receiving conformal radiation therapy (CRT). Methods and Materials: NSCLC patients treated with CRT and tested for PF at baseline were eligible. Baseline predicted values of forced expiratory volume in 1 sec (FEV1), forced vital capacity (FVC), and diffusion capacity of lung for carbon monoxide (DLCO) were analyzed. Additional factors included age, gender, smoking status, Karnofsky performance status, coexisting chronic obstructive pulmonary disease (COPD), tumor location, histology, concurrent chemotherapy, radiation dose, and mean lung dose (MLD) were evaluated for RILT. The primary endpoint was symptomatic RILT (SRILT), including grade ≥2 radiation pneumonitis and fibrosis. Results: There was a total of 260 patients, and SRILT occurred in 58 (22.3%) of them. Mean FEV1 values for SRILT and non-SRILT patients were 71.7% and 65.9% (P=.077). Under univariate analysis, risk of SRILT increased with MLD (P=.008), the absence of COPD (P=.047), and FEV1 (P=.077). Age (65 split) and MLD were significantly associated with SRILT in multivariate analysis. The addition of FEV1 and age with the MLD-based model slightly improved the predictability of SRILT (area under curve from 0.63-0.70, P=.088). Conclusions: Poor baseline PF does not increase the risk of SRILT, and combining FEV1, age, and MLD may improve the predictive ability. © 2013 Elsevier Inc. All rights reserved.-
dc.languageeng-
dc.relation.ispartofInternational Journal of Radiation Oncology Biology Physics-
dc.titlePoor baseline pulmonary function may not increase the risk of radiation-induced lung toxicity-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijrobp.2012.06.040-
dc.identifier.pmid22836048-
dc.identifier.scopuseid_2-s2.0-84873298944-
dc.identifier.volume85-
dc.identifier.issue3-
dc.identifier.spage798-
dc.identifier.epage804-
dc.identifier.eissn1879-355X-
dc.identifier.isiWOS:000314687000047-
dc.identifier.issnl0360-3016-

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