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Article: Advances in Native Chemical Ligation-Desulfurization: A Powerful Strategy for Peptide and Protein Synthesis

TitleAdvances in Native Chemical Ligation-Desulfurization: A Powerful Strategy for Peptide and Protein Synthesis
Authors
KeywordsCysteine surrogates
Desulfurization
Native chemical ligation (NCL)
One-pot synthesis
Proteins
Issue Date2018
PublisherWiley - VCH Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/chemistry
Citation
Chemistry - A European Journal, 2018, v. 24 n. 66, p. 17397-17404 How to Cite?
AbstractCysteine‐based native chemical ligation (NCL) has been a very powerful approach for convergent synthesis of peptides and proteins. However, owing to the low abundance of cysteine (Cys) in proteins, applications of NCL in protein chemical synthesis are limited. To expand the peptide ligation toolbox, NCL followed by desulfurization has been developed to enable peptide ligation at Xaa‐Ala conjunctions, that is, formal “alanine ligation”. In this regard, effective peptide desulfurization methods are critical. This Concept article summarizes the development of different desulfurization strategies for peptide and protein chemical synthesis.
Persistent Identifierhttp://hdl.handle.net/10722/272136
ISSN
2019 Impact Factor: 4.857
2015 SCImago Journal Rankings: 2.323
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJin, K-
dc.contributor.authorLi, X-
dc.date.accessioned2019-07-20T10:36:22Z-
dc.date.available2019-07-20T10:36:22Z-
dc.date.issued2018-
dc.identifier.citationChemistry - A European Journal, 2018, v. 24 n. 66, p. 17397-17404-
dc.identifier.issn0947-6539-
dc.identifier.urihttp://hdl.handle.net/10722/272136-
dc.description.abstractCysteine‐based native chemical ligation (NCL) has been a very powerful approach for convergent synthesis of peptides and proteins. However, owing to the low abundance of cysteine (Cys) in proteins, applications of NCL in protein chemical synthesis are limited. To expand the peptide ligation toolbox, NCL followed by desulfurization has been developed to enable peptide ligation at Xaa‐Ala conjunctions, that is, formal “alanine ligation”. In this regard, effective peptide desulfurization methods are critical. This Concept article summarizes the development of different desulfurization strategies for peptide and protein chemical synthesis.-
dc.languageeng-
dc.publisherWiley - VCH Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www.wiley-vch.de/home/chemistry-
dc.relation.ispartofChemistry - A European Journal-
dc.subjectCysteine surrogates-
dc.subjectDesulfurization-
dc.subjectNative chemical ligation (NCL)-
dc.subjectOne-pot synthesis-
dc.subjectProteins-
dc.titleAdvances in Native Chemical Ligation-Desulfurization: A Powerful Strategy for Peptide and Protein Synthesis-
dc.typeArticle-
dc.identifier.emailLi, X: xuechenl@hku.hk-
dc.identifier.authorityLi, X=rp00742-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/chem.201802067-
dc.identifier.pmid29947435-
dc.identifier.scopuseid_2-s2.0-85054558561-
dc.identifier.hkuros299159-
dc.identifier.volume24-
dc.identifier.issue66-
dc.identifier.spage17397-
dc.identifier.epage17404-
dc.identifier.isiWOS:000451901200003-
dc.publisher.placeGermany-
dc.identifier.issnl0947-6539-

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