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Article: 溃疡性结肠炎患者结肠黏膜5-HT信号通路的变化特点
| Title | 溃疡性结肠炎患者结肠黏膜5-HT信号通路的变化特点 Characteristics of altered 5-hydroxytryptamine signaling in colonic mucosa of patients with ulcerative colitis |
|---|---|
| Authors | |
| Keywords | 5-羟色胺 溃疡性结肠炎 肠嗜铬细胞 色氨酸羟化酶1 5-羟色胺再摄取转运蛋白 |
| Issue Date | 2019 |
| Publisher | 上海市医学科学技术情报研究所. The Journal's web site is located at http://gjxhb.paperopen.com/Default.aspx |
| Citation | 国际消化病杂志, 2019, v. 39 n. 3, p. 222-227 How to Cite? |
| Abstract | 目的 研究溃疡性结肠炎(UC)患者结肠黏膜5-羟色胺(5-HT)信号通路的变化,进一步了解UC的发病机制.方法 经结肠镜检查获得UC患者和健康对照者的结肠黏膜活组织检查标本.用免疫荧光法和ELISA法分别检测肠嗜铬(EC)细胞数、5-HT含量和5-HT释放量.用RT-PCR和免疫荧光检测5-HT合成酶色氨酸羟化酶1(TPH1)和5-羟色胺再摄取转运蛋白(SERT)的基因表达.分析5-HT释放量与UC疾病活动度的相关性.结果 与健康对照组相比,UC患者结肠黏膜嗜铬细胞数、5-HT含量、5-HT释放量和TPH1表达均显著增加,而SERT表达显著减少(P均<0.01).此外,5-HT释放量与UC疾病活动度呈正相关(P<0.01).结论 UC患者结肠黏膜5-HT信号通路有多个环节发生变化,这些变化有助于了解UC的发病机制和开发新的治疗方法. |
| Persistent Identifier | http://hdl.handle.net/10722/272279 |
| ISSN |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Ren, T | - |
| dc.contributor.author | Lvu, M | - |
| dc.contributor.author | An, X | - |
| dc.contributor.author | Xiao, P | - |
| dc.contributor.author | Lin, Y | - |
| dc.contributor.author | Seto, W | - |
| dc.date.accessioned | 2019-07-20T10:39:10Z | - |
| dc.date.available | 2019-07-20T10:39:10Z | - |
| dc.date.issued | 2019 | - |
| dc.identifier.citation | 国际消化病杂志, 2019, v. 39 n. 3, p. 222-227 | - |
| dc.identifier.issn | 1673-534X | - |
| dc.identifier.uri | http://hdl.handle.net/10722/272279 | - |
| dc.description.abstract | 目的 研究溃疡性结肠炎(UC)患者结肠黏膜5-羟色胺(5-HT)信号通路的变化,进一步了解UC的发病机制.方法 经结肠镜检查获得UC患者和健康对照者的结肠黏膜活组织检查标本.用免疫荧光法和ELISA法分别检测肠嗜铬(EC)细胞数、5-HT含量和5-HT释放量.用RT-PCR和免疫荧光检测5-HT合成酶色氨酸羟化酶1(TPH1)和5-羟色胺再摄取转运蛋白(SERT)的基因表达.分析5-HT释放量与UC疾病活动度的相关性.结果 与健康对照组相比,UC患者结肠黏膜嗜铬细胞数、5-HT含量、5-HT释放量和TPH1表达均显著增加,而SERT表达显著减少(P均<0.01).此外,5-HT释放量与UC疾病活动度呈正相关(P<0.01).结论 UC患者结肠黏膜5-HT信号通路有多个环节发生变化,这些变化有助于了解UC的发病机制和开发新的治疗方法. | - |
| dc.language | chi | - |
| dc.publisher | 上海市医学科学技术情报研究所. The Journal's web site is located at http://gjxhb.paperopen.com/Default.aspx | - |
| dc.relation.ispartof | 国际消化病杂志 = International Journal of Digestive Diseases | - |
| dc.subject | 5-羟色胺 | - |
| dc.subject | 溃疡性结肠炎 | - |
| dc.subject | 肠嗜铬细胞 | - |
| dc.subject | 色氨酸羟化酶1 | - |
| dc.subject | 5-羟色胺再摄取转运蛋白 | - |
| dc.title | 溃疡性结肠炎患者结肠黏膜5-HT信号通路的变化特点 | - |
| dc.title | Characteristics of altered 5-hydroxytryptamine signaling in colonic mucosa of patients with ulcerative colitis | - |
| dc.type | Article | - |
| dc.identifier.email | Seto, W: wkseto@hku.hk | - |
| dc.identifier.authority | Seto, W=rp01659 | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.3969/j.issn.1673-534X.2019.03.018 | - |
| dc.identifier.hkuros | 299499 | - |
| dc.identifier.volume | 39 | - |
| dc.identifier.issue | 3 | - |
| dc.identifier.spage | 222 | - |
| dc.identifier.epage | 227 | - |
| dc.publisher.place | Shanghai, China | - |
| dc.identifier.issnl | 1673-534X | - |