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Article: A Pharmacological Appraisal of Neuroprotective and Neurorestorative Flavonoids Against Neurodegenerative Diseases

TitleA Pharmacological Appraisal of Neuroprotective and Neurorestorative Flavonoids Against Neurodegenerative Diseases
Authors
Zhao, JZHU, MKUMAR, MNGO, FYLi, YLao, LRong, J
KeywordsNeurodegenerative diseases
flavonoids
neuroprotective
neurorestorative
pharmacological
Issue Date2019
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cdtcnsnd
Citation
CNS & Neurological Disorders - Drug Targets, 2019, v. 18 n. 2, p. 103-114 How to Cite?
DOI: http://dx.doi.org/10.2174/1871527317666181105093834
AbstractBACKGROUND & OBJECTIVE: Alzheimer's disease (AD) and Parkinson's disease (PD) affect an increasing number of the elderly population worldwide. The existing treatments mainly improve the core symptoms of AD and PD in a temporary manner and cause alarming side effects. Naturally occurring flavonoids are well-documented for neuroprotective and neurorestorative effects against various neurodegenerative diseases. Thus, we analyzed the pharmacokinetics of eight potent natural products flavonoids for the druggability and discussed the neuroprotective and neurorestorative effects and the underlying mechanisms. CONCLUSION: This review provides valuable clues for the development of novel therapeutics against neurodegenerative diseases.
Persistent Identifierhttp://hdl.handle.net/10722/272520
ISSN
1871-5273
2021 Impact Factor: 2.824
2020 SCImago Journal Rankings: 0.923
ISI Accession Number ID
WOS:000461667100002

 

DC FieldValueLanguage
dc.contributor.authorZhao, J-
dc.contributor.authorZHU, M-
dc.contributor.authorKUMAR, M-
dc.contributor.authorNGO, FY-
dc.contributor.authorLi, Y-
dc.contributor.authorLao, L-
dc.contributor.authorRong, J-
dc.date.accessioned2019-07-20T10:43:51Z-
dc.date.available2019-07-20T10:43:51Z-
dc.date.issued2019-
dc.identifier.citationCNS & Neurological Disorders - Drug Targets, 2019, v. 18 n. 2, p. 103-114-
dc.identifier.issn1871-5273-
dc.identifier.urihttp://hdl.handle.net/10722/272520-
dc.description.abstractBACKGROUND & OBJECTIVE: Alzheimer's disease (AD) and Parkinson's disease (PD) affect an increasing number of the elderly population worldwide. The existing treatments mainly improve the core symptoms of AD and PD in a temporary manner and cause alarming side effects. Naturally occurring flavonoids are well-documented for neuroprotective and neurorestorative effects against various neurodegenerative diseases. Thus, we analyzed the pharmacokinetics of eight potent natural products flavonoids for the druggability and discussed the neuroprotective and neurorestorative effects and the underlying mechanisms. CONCLUSION: This review provides valuable clues for the development of novel therapeutics against neurodegenerative diseases.-
dc.languageeng-
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cdtcnsnd-
dc.relation.ispartofCNS & Neurological Disorders - Drug Targets-
dc.subjectNeurodegenerative diseases-
dc.subjectflavonoids-
dc.subjectneuroprotective-
dc.subjectneurorestorative-
dc.subjectpharmacological-
dc.titleA Pharmacological Appraisal of Neuroprotective and Neurorestorative Flavonoids Against Neurodegenerative Diseases-
dc.typeArticle-
dc.identifier.emailZhao, J: zhaojia7@hku.hk-
dc.identifier.emailLao, L: lxlao1@hku.hk-
dc.identifier.emailRong, J: jrong@hku.hk-
dc.identifier.authorityLao, L=rp01784-
dc.identifier.authorityRong, J=rp00515-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2174/1871527317666181105093834-
dc.identifier.pmid30394219-
dc.identifier.scopuseid_2-s2.0-85063945066-
dc.identifier.hkuros298806-
dc.identifier.volume18-
dc.identifier.issue2-
dc.identifier.spage103-
dc.identifier.epage114-
dc.identifier.isiWOS:000461667100002-
dc.publisher.placeNetherlands-
dc.identifier.issnl1871-5273-

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