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- Publisher Website: 10.1002/hed.25544
- Scopus: eid_2-s2.0-85058396457
- PMID: 30548946
- WOS: WOS:000459219300030
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Article: Detection of Epstein-Barr virus (EBV)-encoded microRNAs in plasma of patients with nasopharyngeal carcinoma
Title | Detection of Epstein-Barr virus (EBV)-encoded microRNAs in plasma of patients with nasopharyngeal carcinoma |
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Authors | |
Keywords | circulating nucleic acid EBV DNA EBV‐encoded microRNA Epstein–Barr virus nasopharyngeal carcinoma |
Issue Date | 2019 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0347 |
Citation | Head & Neck, 2019, v. 41 n. 3, p. 780-792 How to Cite? |
Abstract | Background:
Nasopharyngeal carcinoma (NPC) latently infected by Epstein–Barr virus (EBV) expresses 40 EBV BART microRNAs (miRNAs). Difference in diagnostic efficacy of these miRNAs on NPC detection was observed. Here, we performed a comprehensive evaluation on the efficacy of these miRNAs.
Methods:
Quantitative polymerase chain reaction was performed on plasma nucleic acid isolated from patients with NPC and noncancer donors.
Results:
For primary NPC, BART2‐5P, BART6‐3P, BART7‐3P, BART7‐5P, BART9‐5P, BART11‐3P, BART17‐5P, and BART19‐5P were significantly elevated. For recurrent NPC, plasma levels of BART2‐3P, BART2‐5P, BART5‐3P, BART5‐5P, BART6‐3P, BART8‐3P, BART9‐5P, BART17‐5P, BART19‐3P, and BART20‐3P were significantly increased. Area under curve (AUC) analysis showed that BART19‐5P had the best performance to identify NPC which was serologically EBV DNA undetectable. For recurrent NPC, BART8‐3P and BART10‐3P had highest AUC value for identifying cancer in EBV DNA undetectable plasma.
Conclusion:
Our data supported the use of circulating EBV miRNAs in NPC and recurrent NPC detection. |
Persistent Identifier | http://hdl.handle.net/10722/272983 |
ISSN | 2023 Impact Factor: 2.3 2023 SCImago Journal Rankings: 1.034 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Gao, W | - |
dc.contributor.author | Wong, TS | - |
dc.contributor.author | Lv, KX | - |
dc.contributor.author | Zhang, MJ | - |
dc.contributor.author | Tsang, RKY | - |
dc.contributor.author | Chan, JYW | - |
dc.date.accessioned | 2019-08-06T09:20:23Z | - |
dc.date.available | 2019-08-06T09:20:23Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Head & Neck, 2019, v. 41 n. 3, p. 780-792 | - |
dc.identifier.issn | 1043-3074 | - |
dc.identifier.uri | http://hdl.handle.net/10722/272983 | - |
dc.description.abstract | Background: Nasopharyngeal carcinoma (NPC) latently infected by Epstein–Barr virus (EBV) expresses 40 EBV BART microRNAs (miRNAs). Difference in diagnostic efficacy of these miRNAs on NPC detection was observed. Here, we performed a comprehensive evaluation on the efficacy of these miRNAs. Methods: Quantitative polymerase chain reaction was performed on plasma nucleic acid isolated from patients with NPC and noncancer donors. Results: For primary NPC, BART2‐5P, BART6‐3P, BART7‐3P, BART7‐5P, BART9‐5P, BART11‐3P, BART17‐5P, and BART19‐5P were significantly elevated. For recurrent NPC, plasma levels of BART2‐3P, BART2‐5P, BART5‐3P, BART5‐5P, BART6‐3P, BART8‐3P, BART9‐5P, BART17‐5P, BART19‐3P, and BART20‐3P were significantly increased. Area under curve (AUC) analysis showed that BART19‐5P had the best performance to identify NPC which was serologically EBV DNA undetectable. For recurrent NPC, BART8‐3P and BART10‐3P had highest AUC value for identifying cancer in EBV DNA undetectable plasma. Conclusion: Our data supported the use of circulating EBV miRNAs in NPC and recurrent NPC detection. | - |
dc.language | eng | - |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0347 | - |
dc.relation.ispartof | Head & Neck | - |
dc.rights | This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | - |
dc.subject | circulating nucleic acid | - |
dc.subject | EBV DNA | - |
dc.subject | EBV‐encoded microRNA | - |
dc.subject | Epstein–Barr virus | - |
dc.subject | nasopharyngeal carcinoma | - |
dc.title | Detection of Epstein-Barr virus (EBV)-encoded microRNAs in plasma of patients with nasopharyngeal carcinoma | - |
dc.type | Article | - |
dc.identifier.email | Gao, W: weigaoi@hku.hk | - |
dc.identifier.email | Wong, TS: wongtsa@hkucc.hku.hk | - |
dc.identifier.email | Tsang, RKY: rkytsang@hku.hk | - |
dc.identifier.email | Chan, JYW: jywchan1@HKUCC-COM.hku.hk | - |
dc.identifier.authority | Gao, W=rp02222 | - |
dc.identifier.authority | Wong, TS=rp00478 | - |
dc.identifier.authority | Tsang, RKY=rp01386 | - |
dc.identifier.authority | Chan, JYW=rp01314 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/hed.25544 | - |
dc.identifier.pmid | 30548946 | - |
dc.identifier.scopus | eid_2-s2.0-85058396457 | - |
dc.identifier.hkuros | 299864 | - |
dc.identifier.volume | 41 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 780 | - |
dc.identifier.epage | 792 | - |
dc.identifier.isi | WOS:000459219300030 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1043-3074 | - |