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- Publisher Website: 10.1038/nchembio.2157
- Scopus: eid_2-s2.0-84983505484
- PMID: 27547923
- WOS: WOS:000384248600006
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Article: Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin
| Title | Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin |
|---|---|
| Authors | |
| Issue Date | 2016 |
| Citation | Nature Chemical Biology, 2016, v. 12, n. 10, p. 773-775 How to Cite? |
| Abstract | © 2016 Nature America, Inc. Colibactin is an as-yet-uncharacterized genotoxic secondary metabolite produced by human gut bacteria. Here we report the biosynthetic discovery of two new precolibactin molecules from Escherichia coli, including precolibactin-886, which uniquely incorporates the highly sought genotoxicity-associated aminomalonate building block into its unprecedented macrocyclic structure. This work provides new insights into the biosynthetic logic and mode of action of this colorectal-cancer-linked microbial chemical. |
| Persistent Identifier | http://hdl.handle.net/10722/273567 |
| ISSN | 2023 Impact Factor: 12.9 2023 SCImago Journal Rankings: 5.558 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Li, Zhong Rui | - |
| dc.contributor.author | Li, Jie | - |
| dc.contributor.author | Gu, Jin Ping | - |
| dc.contributor.author | Lai, Jennifer Y.H. | - |
| dc.contributor.author | Duggan, Brendan M. | - |
| dc.contributor.author | Zhang, Wei Peng | - |
| dc.contributor.author | Li, Zhi Long | - |
| dc.contributor.author | Li, Yong Xin | - |
| dc.contributor.author | Tong, Rong Biao | - |
| dc.contributor.author | Xu, Ying | - |
| dc.contributor.author | Lin, Dong Hai | - |
| dc.contributor.author | Moore, Bradley S. | - |
| dc.contributor.author | Qian, Pei Yuan | - |
| dc.date.accessioned | 2019-08-12T09:55:57Z | - |
| dc.date.available | 2019-08-12T09:55:57Z | - |
| dc.date.issued | 2016 | - |
| dc.identifier.citation | Nature Chemical Biology, 2016, v. 12, n. 10, p. 773-775 | - |
| dc.identifier.issn | 1552-4450 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/273567 | - |
| dc.description.abstract | © 2016 Nature America, Inc. Colibactin is an as-yet-uncharacterized genotoxic secondary metabolite produced by human gut bacteria. Here we report the biosynthetic discovery of two new precolibactin molecules from Escherichia coli, including precolibactin-886, which uniquely incorporates the highly sought genotoxicity-associated aminomalonate building block into its unprecedented macrocyclic structure. This work provides new insights into the biosynthetic logic and mode of action of this colorectal-cancer-linked microbial chemical. | - |
| dc.language | eng | - |
| dc.relation.ispartof | Nature Chemical Biology | - |
| dc.title | Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin | - |
| dc.type | Article | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.1038/nchembio.2157 | - |
| dc.identifier.pmid | 27547923 | - |
| dc.identifier.scopus | eid_2-s2.0-84983505484 | - |
| dc.identifier.volume | 12 | - |
| dc.identifier.issue | 10 | - |
| dc.identifier.spage | 773 | - |
| dc.identifier.epage | 775 | - |
| dc.identifier.eissn | 1552-4469 | - |
| dc.identifier.isi | WOS:000384248600006 | - |
| dc.identifier.issnl | 1552-4450 | - |