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Article: Cell migration according to shape of graphene oxide micropatterns
Title | Cell migration according to shape of graphene oxide micropatterns |
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Authors | |
Keywords | Photolithography Cell migration Meniscus-dragging deposition Micropatterns Graphene oxide |
Issue Date | 2016 |
Citation | Micromachines, 2016, v. 7, n. 10, article no. 186 How to Cite? |
Abstract | © 2016 by the authors. Photolithography is a unique process that can effectively manufacture micro/nano-sized patterns on various substrates. On the other hand, the meniscus-dragging deposition (MDD) process can produce a uniform surface of the substrate. Graphene oxide (GO) is the oxidized form of graphene that has high hydrophilicity and protein absorption. It is widely used in biomedical fields such as drug delivery, regenerative medicine, and tissue engineering. Herein, we fabricated uniform GO micropatterns via MDD and photolithography. The physicochemical properties of the GO micropatterns were characterized by atomic force microscopy (AFM), scanning electron microscopy (SEM), and Raman spectroscopy. Furthermore, cell migration on the GO micropatterns was investigated, and the difference in cell migration on triangle and square GO micropatterns was examined for their effects on cell migration. Our results demonstrated that the GO micropatterns with a desired shape can be finely fabricated via MDD and photolithography. Moreover, it was revealed that the shape of GO micropatterns plays a crucial role in cell migration distance, speed, and directionality. Therefore, our findings suggest that the GO micropatterns can serve as a promising biofunctional platform and cell-guiding substrate for applications to bioelectric devices, cell-on-a-chip, and tissue engineering scaffolds. |
Persistent Identifier | http://hdl.handle.net/10722/273578 |
ISSN | 2023 Impact Factor: 3.0 2023 SCImago Journal Rankings: 0.549 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Kim, Sung Eun | - |
dc.contributor.author | Kim, Min Sung | - |
dc.contributor.author | Shin, Yong Cheol | - |
dc.contributor.author | Eom, Seong Un | - |
dc.contributor.author | Lee, Jong Ho | - |
dc.contributor.author | Shin, Dong Myeong | - |
dc.contributor.author | Hong, Suck Won | - |
dc.contributor.author | Kim, Bongju | - |
dc.contributor.author | Park, Jong Chul | - |
dc.contributor.author | Shin, Bo Sung | - |
dc.contributor.author | Lim, Dohyung | - |
dc.contributor.author | Han, Dong Wook | - |
dc.date.accessioned | 2019-08-12T09:55:59Z | - |
dc.date.available | 2019-08-12T09:55:59Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Micromachines, 2016, v. 7, n. 10, article no. 186 | - |
dc.identifier.issn | 2072-666X | - |
dc.identifier.uri | http://hdl.handle.net/10722/273578 | - |
dc.description.abstract | © 2016 by the authors. Photolithography is a unique process that can effectively manufacture micro/nano-sized patterns on various substrates. On the other hand, the meniscus-dragging deposition (MDD) process can produce a uniform surface of the substrate. Graphene oxide (GO) is the oxidized form of graphene that has high hydrophilicity and protein absorption. It is widely used in biomedical fields such as drug delivery, regenerative medicine, and tissue engineering. Herein, we fabricated uniform GO micropatterns via MDD and photolithography. The physicochemical properties of the GO micropatterns were characterized by atomic force microscopy (AFM), scanning electron microscopy (SEM), and Raman spectroscopy. Furthermore, cell migration on the GO micropatterns was investigated, and the difference in cell migration on triangle and square GO micropatterns was examined for their effects on cell migration. Our results demonstrated that the GO micropatterns with a desired shape can be finely fabricated via MDD and photolithography. Moreover, it was revealed that the shape of GO micropatterns plays a crucial role in cell migration distance, speed, and directionality. Therefore, our findings suggest that the GO micropatterns can serve as a promising biofunctional platform and cell-guiding substrate for applications to bioelectric devices, cell-on-a-chip, and tissue engineering scaffolds. | - |
dc.language | eng | - |
dc.relation.ispartof | Micromachines | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Photolithography | - |
dc.subject | Cell migration | - |
dc.subject | Meniscus-dragging deposition | - |
dc.subject | Micropatterns | - |
dc.subject | Graphene oxide | - |
dc.title | Cell migration according to shape of graphene oxide micropatterns | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3390/mi7100186 | - |
dc.identifier.scopus | eid_2-s2.0-84994803111 | - |
dc.identifier.volume | 7 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | article no. 186 | - |
dc.identifier.epage | article no. 186 | - |
dc.identifier.isi | WOS:000389131300016 | - |
dc.identifier.issnl | 2072-666X | - |