Color contrast adaptation: fMRI fails to predict behavioral adaptation

Abstract

fMRI-adaptation is a valuable tool for inferring the selectivity of neural responses. Here we use it in human color vision to test the selectivity of responses to S-cone opponent (blue-yellow), L/M-cone opponent (red-green), and achromatic (Ach) contrast across nine regions of interest in visual cortex. We measure psychophysical adaptation, using comparable stimuli to the fMRI-adaptation, and find significant selective adaptation for all three stimulus types, implying separable visual responses to each. For fMRI-adaptation, we find robust adaptation but, surprisingly, much less selectivity due to high levels of cross-stimulus adaptation in all conditions. For all BY and Ach test/adaptor pairs, selectivity is absent across all ROIs. For RG/Ach stimulus pairs, this paradigm has previously shown selectivity for RG in ventral areas and for Ach in dorsal areas. For chromatic stimulus pairs (RG/BY), we find a trend for selectivity in ventral areas. In conclusion, we find an overall lack of correspondence between BOLD and behavioral adaptation suggesting they reflect different aspects of the underlying neural processes. For example, raised cross-stimulus adaptation in fMRI may reflect adaptation of the broadly-tuned normalization pool. Finally, we also identify a longer-timescale adaptation (1h) in both BOLD and behavioral data. This is greater for chromatic than achromatic contrast. The longer-timescale BOLD effect was more evident in the higher ventral areas than in V1, consistent with increasing windows of temporal integration for higher-order areas. © 2019 Elsevier Inc.