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Article: Centromeric non-coding RNA as a hidden epigenetic factor of the point centromere

TitleCentromeric non-coding RNA as a hidden epigenetic factor of the point centromere
Authors
KeywordsCentromere-binding factor Cbf1
Centromeric histone variant CENP-A
Centromeric transcription
Chromosome instability
Histone H2A variant Htz1
Issue Date2019
PublisherSpringer Verlag. The Journal's web site is located at http://www.springer.com/life+sci/genetics/journal/294
Citation
Current Genetics: lower eukaryotes and organelles, 2019, v. 65 n. 5, p. 1165-1171 How to Cite?
AbstractTo ensure proper chromosome segregation during cell division, the centromere in many organisms is transcribed to produce a low level of long non-coding RNA to regulate the activity of the kinetochore. In the budding yeast point centromere, our recent work has shown that the level of centromeric RNAs (cenRNAs) is tightly regulated and repressed by the kinetochore protein Cbf1 and histone H2A variant H2A.Z Htz1 , and de-repressed during S phase of the cell cycle. Too little or too much cenRNAs will disrupt centromere activity. Here, we discuss the current advance in the understanding of the action and regulation of cenRNAs at the point centromere of Saccharomyces cerevisiae. We further show that budding yeast cenRNAs are cryptic unstable transcripts (CUTs) that can be degraded by the nuclear RNA decay pathway. CenRNA provides an example that even CUTs, when present at the right time with the right level, can serve important cellular functions. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
Persistent Identifierhttp://hdl.handle.net/10722/274289
ISSN
2023 Impact Factor: 1.8
2023 SCImago Journal Rankings: 0.838
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLing, YH-
dc.contributor.authorYuen, KWY-
dc.date.accessioned2019-08-18T14:58:48Z-
dc.date.available2019-08-18T14:58:48Z-
dc.date.issued2019-
dc.identifier.citationCurrent Genetics: lower eukaryotes and organelles, 2019, v. 65 n. 5, p. 1165-1171-
dc.identifier.issn0172-8083-
dc.identifier.urihttp://hdl.handle.net/10722/274289-
dc.description.abstractTo ensure proper chromosome segregation during cell division, the centromere in many organisms is transcribed to produce a low level of long non-coding RNA to regulate the activity of the kinetochore. In the budding yeast point centromere, our recent work has shown that the level of centromeric RNAs (cenRNAs) is tightly regulated and repressed by the kinetochore protein Cbf1 and histone H2A variant H2A.Z Htz1 , and de-repressed during S phase of the cell cycle. Too little or too much cenRNAs will disrupt centromere activity. Here, we discuss the current advance in the understanding of the action and regulation of cenRNAs at the point centromere of Saccharomyces cerevisiae. We further show that budding yeast cenRNAs are cryptic unstable transcripts (CUTs) that can be degraded by the nuclear RNA decay pathway. CenRNA provides an example that even CUTs, when present at the right time with the right level, can serve important cellular functions. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.-
dc.languageeng-
dc.publisherSpringer Verlag. The Journal's web site is located at http://www.springer.com/life+sci/genetics/journal/294-
dc.relation.ispartofCurrent Genetics: lower eukaryotes and organelles-
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: http://dx.doi.org/[insert DOI]-
dc.subjectCentromere-binding factor Cbf1-
dc.subjectCentromeric histone variant CENP-A-
dc.subjectCentromeric transcription-
dc.subjectChromosome instability-
dc.subjectHistone H2A variant Htz1-
dc.titleCentromeric non-coding RNA as a hidden epigenetic factor of the point centromere-
dc.typeArticle-
dc.identifier.emailLing, YH: yhling@hku.hk-
dc.identifier.emailYuen, KWY: kwyyuen@hku.hk-
dc.identifier.authorityYuen, KWY=rp01512-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00294-019-00988-6-
dc.identifier.pmid31073666-
dc.identifier.scopuseid_2-s2.0-85065657392-
dc.identifier.hkuros302021-
dc.identifier.volume65-
dc.identifier.issue5-
dc.identifier.spage1165-
dc.identifier.epage1171-
dc.identifier.isiWOS:000485990000013-
dc.publisher.placeGermany-
dc.identifier.issnl0172-8083-

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