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Book Chapter: Assessing the Evolutionary Conservation of Protein Disulphide Bonds

TitleAssessing the Evolutionary Conservation of Protein Disulphide Bonds
Authors
KeywordsDisulphide bonds
Cysteine
Evolution
Conservation
Bioinformatics
Issue Date2019
PublisherHumana
Citation
Assessing the Evolutionary Conservation of Protein Disulphide Bonds. In Hogg, P.J. (Eds.), Functional Disulphide Bonds : Methods and Protocols, p. 9-19. New York, NY: Humana, 2019 How to Cite?
AbstractStudying the evolutionary conservation of proteins can be a valuable tool for understanding its function. At the sequence level, the conservation of each residue can be used to infer the importance of the particular regions of proteins. In the case of protein disulphide bonds, the conservation of the cysteines involved can be used to infer the conservation of the disulphide bond itself. In this chapter, bioinformatics methods are described that can be used to assess the conservation of a protein disulphide bond with a focus on the study of human proteins. Conservation will be assessed at the species and at the human population level. The methods described make use of publicly available databases and can be applied by any researcher using a standard desktop computer with Internet access.
Persistent Identifierhttp://hdl.handle.net/10722/274397
ISBN
ISSN
2023 SCImago Journal Rankings: 0.399
Series/Report no.Methods in Molecular Biology ; v. 1967

 

DC FieldValueLanguage
dc.contributor.authorWong, WHJ-
dc.date.accessioned2019-08-18T15:00:55Z-
dc.date.available2019-08-18T15:00:55Z-
dc.date.issued2019-
dc.identifier.citationAssessing the Evolutionary Conservation of Protein Disulphide Bonds. In Hogg, P.J. (Eds.), Functional Disulphide Bonds : Methods and Protocols, p. 9-19. New York, NY: Humana, 2019-
dc.identifier.isbn9781493991860-
dc.identifier.issn1064-3745-
dc.identifier.urihttp://hdl.handle.net/10722/274397-
dc.description.abstractStudying the evolutionary conservation of proteins can be a valuable tool for understanding its function. At the sequence level, the conservation of each residue can be used to infer the importance of the particular regions of proteins. In the case of protein disulphide bonds, the conservation of the cysteines involved can be used to infer the conservation of the disulphide bond itself. In this chapter, bioinformatics methods are described that can be used to assess the conservation of a protein disulphide bond with a focus on the study of human proteins. Conservation will be assessed at the species and at the human population level. The methods described make use of publicly available databases and can be applied by any researcher using a standard desktop computer with Internet access.-
dc.languageeng-
dc.publisherHumana-
dc.relation.ispartofFunctional Disulphide Bonds : Methods and Protocols-
dc.relation.ispartofseriesMethods in Molecular Biology ; v. 1967-
dc.subjectDisulphide bonds-
dc.subjectCysteine-
dc.subjectEvolution-
dc.subjectConservation-
dc.subjectBioinformatics-
dc.titleAssessing the Evolutionary Conservation of Protein Disulphide Bonds-
dc.typeBook_Chapter-
dc.identifier.emailWong, WHJ: jwhwong@hku.hk-
dc.identifier.authorityWong, WHJ=rp02363-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/978-1-4939-9187-7_2-
dc.identifier.scopuseid_2-s2.0-85065797339-
dc.identifier.hkuros301993-
dc.identifier.volume1967-
dc.identifier.spage9-
dc.identifier.epage19-
dc.identifier.eissn1940-6029-
dc.publisher.placeNew York, NY-
dc.identifier.issnl1064-3745-

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