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Article: Effects of aspect ratio, wall thickness and hypertension in the patient-specific computational modeling of cerebral aneurysms using fluid structure interaction analysis

TitleEffects of aspect ratio, wall thickness and hypertension in the patient-specific computational modeling of cerebral aneurysms using fluid structure interaction analysis
Authors
Keywordsaspect ratio
fluid-structure interaction
FSI
hypertension
Intracranial aneurysms
Issue Date2019
PublisherHong Kong Polytechnic University. The Journal's web site is located at http://jeacfm.cse.polyu.edu.hk/
Citation
Engineering Applications of Computational Fluid Mechanics, 2019, v. 13 n. 1, p. 229-244 How to Cite?
AbstractIntracranial aneurysm is a pathological dilatation of the cerebral artery which can lead to high mortality rate upon rupture. The aspect ratio (AR) of an aneurysm, being the ratio of the height to neck width, is an important factor in estimating the likelihood of aneurysm rupture in clinical practice. AR will generally increase while the aneurysm grows. Clinical observations over the years show that aneurysms with larger AR usually exhibit higher rupture risk. The goal of the current study is to conduct Fluid-Structure Interaction (FSI) analyses to provide quantitative estimates on the importance of AR, wall thickness (tw) and hypertension. The effects of varying AR and tw on the hemodynamics, wall stress and displacement will be studied based on patient-specific models. Both sidewall and bifurcation aneurysms are investigated. There is a significant increase in the wall stress at the aneurysmal dome (the location in an aneurysm where rupture is commonly observed clinically) when the AR increases and tw decreases due to the aneurysm growth process. Furthermore, these investigations are repeated for patients with hypertension (high blood pressure) conditions. The increase in the wall stress due to hypertension for models with higher ARs is more dramatic. The clinically observed feature of higher rupture risk of aneurysms with larger AR is thus supported quantitatively. © 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Persistent Identifierhttp://hdl.handle.net/10722/275057
ISSN
2019 Impact Factor: 5.8
2015 SCImago Journal Rankings: 0.626
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSun, H-
dc.contributor.authorSze, KY-
dc.contributor.authorTang, YS-
dc.contributor.authorTsang, COA-
dc.contributor.authorYu, ACH-
dc.contributor.authorChow, KW-
dc.date.accessioned2019-09-10T02:34:33Z-
dc.date.available2019-09-10T02:34:33Z-
dc.date.issued2019-
dc.identifier.citationEngineering Applications of Computational Fluid Mechanics, 2019, v. 13 n. 1, p. 229-244-
dc.identifier.issn1994-2060-
dc.identifier.urihttp://hdl.handle.net/10722/275057-
dc.description.abstractIntracranial aneurysm is a pathological dilatation of the cerebral artery which can lead to high mortality rate upon rupture. The aspect ratio (AR) of an aneurysm, being the ratio of the height to neck width, is an important factor in estimating the likelihood of aneurysm rupture in clinical practice. AR will generally increase while the aneurysm grows. Clinical observations over the years show that aneurysms with larger AR usually exhibit higher rupture risk. The goal of the current study is to conduct Fluid-Structure Interaction (FSI) analyses to provide quantitative estimates on the importance of AR, wall thickness (tw) and hypertension. The effects of varying AR and tw on the hemodynamics, wall stress and displacement will be studied based on patient-specific models. Both sidewall and bifurcation aneurysms are investigated. There is a significant increase in the wall stress at the aneurysmal dome (the location in an aneurysm where rupture is commonly observed clinically) when the AR increases and tw decreases due to the aneurysm growth process. Furthermore, these investigations are repeated for patients with hypertension (high blood pressure) conditions. The increase in the wall stress due to hypertension for models with higher ARs is more dramatic. The clinically observed feature of higher rupture risk of aneurysms with larger AR is thus supported quantitatively. © 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.-
dc.languageeng-
dc.publisherHong Kong Polytechnic University. The Journal's web site is located at http://jeacfm.cse.polyu.edu.hk/-
dc.relation.ispartofEngineering Applications of Computational Fluid Mechanics-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectaspect ratio-
dc.subjectfluid-structure interaction-
dc.subjectFSI-
dc.subjecthypertension-
dc.subjectIntracranial aneurysms-
dc.titleEffects of aspect ratio, wall thickness and hypertension in the patient-specific computational modeling of cerebral aneurysms using fluid structure interaction analysis-
dc.typeArticle-
dc.identifier.emailSze, KY: kysze@hku.hk-
dc.identifier.emailTsang, COA: acotsang@hku.hk-
dc.identifier.emailChow, KW: kwchow@hku.hk-
dc.identifier.authoritySze, KY=rp00171-
dc.identifier.authorityTsang, COA=rp01519-
dc.identifier.authorityChow, KW=rp00112-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1080/19942060.2019.1572540-
dc.identifier.scopuseid_2-s2.0-85064979604-
dc.identifier.hkuros302868-
dc.identifier.volume13-
dc.identifier.issue1-
dc.identifier.spage229-
dc.identifier.epage244-
dc.identifier.isiWOS:000458462800001-
dc.publisher.placeHong Kong-
dc.identifier.issnl1994-2060-

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