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Article: Synthesis of bio-inspired viscoelastic molecular networks by metal-induced protein assembly

TitleSynthesis of bio-inspired viscoelastic molecular networks by metal-induced protein assembly
Authors
Issue Date2020
PublisherRoyal Society of Chemistry. The Journal's web site is located at https://www.rsc.org/journals-books-databases/about-journals/msde/
Citation
Molecular Systems Design & Engineering, 2020, v. 5 n. 1, p. 117-124 How to Cite?
AbstractAn inducible protein assembly system is desirable for developing high-order biomolecular architectures with dynamic properties. Here we demonstrate the creation of molecular networks with distinct stress-relaxation behavior using metal-induced protein assembly—a process that involves the folding and reconstitution of a pair of split IgG-binding GB1 proteins. In addition, metal–ligand coordination within the protein networks exerted great influence over their viscoelastic properties. The resulting protein networks are self-healable, amenable to biochemical decoration via SpyTag/SpyCatcher chemistry, and compatible with 3D culture of fibroblasts. This study points to a simple and robust strategy for designing recombinant protein hydrogels with tunable biochemical and mechanical properties.
Persistent Identifierhttp://hdl.handle.net/10722/275063
ISSN
2020 Impact Factor: 4.935
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCao, Y-
dc.contributor.authorWei, X-
dc.contributor.authorLin, Y-
dc.contributor.authorSun, F-
dc.date.accessioned2019-09-10T02:34:41Z-
dc.date.available2019-09-10T02:34:41Z-
dc.date.issued2020-
dc.identifier.citationMolecular Systems Design & Engineering, 2020, v. 5 n. 1, p. 117-124-
dc.identifier.issn2058-9689-
dc.identifier.urihttp://hdl.handle.net/10722/275063-
dc.description.abstractAn inducible protein assembly system is desirable for developing high-order biomolecular architectures with dynamic properties. Here we demonstrate the creation of molecular networks with distinct stress-relaxation behavior using metal-induced protein assembly—a process that involves the folding and reconstitution of a pair of split IgG-binding GB1 proteins. In addition, metal–ligand coordination within the protein networks exerted great influence over their viscoelastic properties. The resulting protein networks are self-healable, amenable to biochemical decoration via SpyTag/SpyCatcher chemistry, and compatible with 3D culture of fibroblasts. This study points to a simple and robust strategy for designing recombinant protein hydrogels with tunable biochemical and mechanical properties.-
dc.languageeng-
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at https://www.rsc.org/journals-books-databases/about-journals/msde/-
dc.relation.ispartofMolecular Systems Design & Engineering-
dc.titleSynthesis of bio-inspired viscoelastic molecular networks by metal-induced protein assembly-
dc.typeArticle-
dc.identifier.emailLin, Y: ylin@hkucc.hku.hk-
dc.identifier.authorityLin, Y=rp00080-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/C9ME00027E-
dc.identifier.scopuseid_2-s2.0-85078535212-
dc.identifier.hkuros304188-
dc.identifier.volume5-
dc.identifier.issue1-
dc.identifier.spage117-
dc.identifier.epage124-
dc.identifier.isiWOS:000508398900008-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl2058-9689-

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