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- Publisher Website: 10.1039/C9ME00027E
- Scopus: eid_2-s2.0-85078535212
- WOS: WOS:000508398900008
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Article: Synthesis of bio-inspired viscoelastic molecular networks by metal-induced protein assembly
Title | Synthesis of bio-inspired viscoelastic molecular networks by metal-induced protein assembly |
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Authors | |
Issue Date | 2020 |
Publisher | Royal Society of Chemistry. The Journal's web site is located at https://www.rsc.org/journals-books-databases/about-journals/msde/ |
Citation | Molecular Systems Design & Engineering, 2020, v. 5 n. 1, p. 117-124 How to Cite? |
Abstract | An inducible protein assembly system is desirable for developing high-order biomolecular architectures with dynamic properties. Here we demonstrate the creation of molecular networks with distinct stress-relaxation behavior using metal-induced protein assembly—a process that involves the folding and reconstitution of a pair of split IgG-binding GB1 proteins. In addition, metal–ligand coordination within the protein networks exerted great influence over their viscoelastic properties. The resulting protein networks are self-healable, amenable to biochemical decoration via SpyTag/SpyCatcher chemistry, and compatible with 3D culture of fibroblasts. This study points to a simple and robust strategy for designing recombinant protein hydrogels with tunable biochemical and mechanical properties. |
Persistent Identifier | http://hdl.handle.net/10722/275063 |
ISSN | 2023 Impact Factor: 3.2 2023 SCImago Journal Rankings: 0.783 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Cao, Y | - |
dc.contributor.author | Wei, X | - |
dc.contributor.author | Lin, Y | - |
dc.contributor.author | Sun, F | - |
dc.date.accessioned | 2019-09-10T02:34:41Z | - |
dc.date.available | 2019-09-10T02:34:41Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Molecular Systems Design & Engineering, 2020, v. 5 n. 1, p. 117-124 | - |
dc.identifier.issn | 2058-9689 | - |
dc.identifier.uri | http://hdl.handle.net/10722/275063 | - |
dc.description.abstract | An inducible protein assembly system is desirable for developing high-order biomolecular architectures with dynamic properties. Here we demonstrate the creation of molecular networks with distinct stress-relaxation behavior using metal-induced protein assembly—a process that involves the folding and reconstitution of a pair of split IgG-binding GB1 proteins. In addition, metal–ligand coordination within the protein networks exerted great influence over their viscoelastic properties. The resulting protein networks are self-healable, amenable to biochemical decoration via SpyTag/SpyCatcher chemistry, and compatible with 3D culture of fibroblasts. This study points to a simple and robust strategy for designing recombinant protein hydrogels with tunable biochemical and mechanical properties. | - |
dc.language | eng | - |
dc.publisher | Royal Society of Chemistry. The Journal's web site is located at https://www.rsc.org/journals-books-databases/about-journals/msde/ | - |
dc.relation.ispartof | Molecular Systems Design & Engineering | - |
dc.title | Synthesis of bio-inspired viscoelastic molecular networks by metal-induced protein assembly | - |
dc.type | Article | - |
dc.identifier.email | Lin, Y: ylin@hkucc.hku.hk | - |
dc.identifier.authority | Lin, Y=rp00080 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1039/C9ME00027E | - |
dc.identifier.scopus | eid_2-s2.0-85078535212 | - |
dc.identifier.hkuros | 304188 | - |
dc.identifier.volume | 5 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 117 | - |
dc.identifier.epage | 124 | - |
dc.identifier.isi | WOS:000508398900008 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 2058-9689 | - |