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Article: Pre-treatment quality of life as a predictor of distant metastasis-free survival and overall survival in patients with head and neck cancer who underwent free flap reconstruction

TitlePre-treatment quality of life as a predictor of distant metastasis-free survival and overall survival in patients with head and neck cancer who underwent free flap reconstruction
Authors
KeywordsQuality of life
Head and neck cancer
Metastasis
Oncological outcome
Issue Date2019
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/ejon
Citation
European Journal of Oncology Nursing, 2019, v. 41, p. 1-6 How to Cite?
AbstractPurpose: This study examined the prognostic associations of pre-treatment quality of life (QoL) with overall survival (OS) and distant metastasis-free survival (DFMS) among patients with head and neck cancer (HNC) who underwent free flap reconstruction. Methods: A cohort of 127 HNC patients who received free flap reconstruction between November 2010 and June 2014 at a hospital were recruited. Pre-treatment QoL was measured by the University of Washington Quality of Life Questionnaire, which contains six physical domains, including speech, swallowing, appearance, saliva, taste and chewing, as well as the six social-emotional domains of pain, activity, recreation, shoulder, mood, and anxiety. Cox regression analyses were performed. Results: Results showed that pre-treatment QoL was predictive of OS and DMFS. Of the domains, swallowing, chewing, speech, taste, saliva, pain and shoulder were demonstrated to be significant predictors of OS. Additionally, swallowing, chewing, speech, pain and activity were demonstrated making significant contributions to DMFS. Conclusion: Our data supported that physical domains of pre-treatment QoL were predictors for OS and DFMS in HNC patients with free-flap reconstruction. Longitudinal studies are warranted to clarify the prognostic abilities of social-emotional domains. Information on pre-treatment QoL should be taken into account to individualize care plan for these patients, and hence prolong their survival.
Persistent Identifierhttp://hdl.handle.net/10722/275351
ISSN
2023 Impact Factor: 2.7
2023 SCImago Journal Rankings: 0.801
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, MN-
dc.contributor.authorHo, KY-
dc.contributor.authorHung, YN-
dc.contributor.authorSu, CC-
dc.contributor.authorKuan, CH-
dc.contributor.authorTai, HC-
dc.contributor.authorCheng, NC-
dc.contributor.authorLin, CC-
dc.date.accessioned2019-09-10T02:40:48Z-
dc.date.available2019-09-10T02:40:48Z-
dc.date.issued2019-
dc.identifier.citationEuropean Journal of Oncology Nursing, 2019, v. 41, p. 1-6-
dc.identifier.issn1462-3889-
dc.identifier.urihttp://hdl.handle.net/10722/275351-
dc.description.abstractPurpose: This study examined the prognostic associations of pre-treatment quality of life (QoL) with overall survival (OS) and distant metastasis-free survival (DFMS) among patients with head and neck cancer (HNC) who underwent free flap reconstruction. Methods: A cohort of 127 HNC patients who received free flap reconstruction between November 2010 and June 2014 at a hospital were recruited. Pre-treatment QoL was measured by the University of Washington Quality of Life Questionnaire, which contains six physical domains, including speech, swallowing, appearance, saliva, taste and chewing, as well as the six social-emotional domains of pain, activity, recreation, shoulder, mood, and anxiety. Cox regression analyses were performed. Results: Results showed that pre-treatment QoL was predictive of OS and DMFS. Of the domains, swallowing, chewing, speech, taste, saliva, pain and shoulder were demonstrated to be significant predictors of OS. Additionally, swallowing, chewing, speech, pain and activity were demonstrated making significant contributions to DMFS. Conclusion: Our data supported that physical domains of pre-treatment QoL were predictors for OS and DFMS in HNC patients with free-flap reconstruction. Longitudinal studies are warranted to clarify the prognostic abilities of social-emotional domains. Information on pre-treatment QoL should be taken into account to individualize care plan for these patients, and hence prolong their survival.-
dc.languageeng-
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/ejon-
dc.relation.ispartofEuropean Journal of Oncology Nursing-
dc.subjectQuality of life-
dc.subjectHead and neck cancer-
dc.subjectMetastasis-
dc.subjectOncological outcome-
dc.titlePre-treatment quality of life as a predictor of distant metastasis-free survival and overall survival in patients with head and neck cancer who underwent free flap reconstruction-
dc.typeArticle-
dc.identifier.emailHo, KY: devilbb2@hku.hk-
dc.identifier.emailLin, CC: cclin@hku.hk-
dc.identifier.authorityHo, KY=rp02339-
dc.identifier.authorityLin, CC=rp02265-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ejon.2019.05.003-
dc.identifier.pmid31358241-
dc.identifier.scopuseid_2-s2.0-85066275417-
dc.identifier.hkuros304293-
dc.identifier.volume41-
dc.identifier.spage1-
dc.identifier.epage6-
dc.identifier.isiWOS:000482249100001-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1462-3889-

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