File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The Role of Exosomal MicroRNAs in the Tumor Microenvironment of Breast Cancer

TitleThe Role of Exosomal MicroRNAs in the Tumor Microenvironment of Breast Cancer
Authors
Keywordsbreast cancer
tumor microenvironment
exosomes
microRNA
biomarker
Issue Date2019
PublisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms
Citation
International Journal of Molecular Sciences, 2019, v. 20 n. 16, p. article no. 3884 How to Cite?
AbstractBreast cancer, ranking first among women’s cancers worldwide, develops from the breast tissue. Study of the breast tissue is, therefore of great significance to the diagnosis and treatment of breast cancer. Exosomes, acting as an effective communicator between cells, are in the ascendant in recent years. One of the most important cargoes contained in the exosomes is microRNAs, belonging to the non-coding RNA family. When the exosomal microRNAs are absorbed into the intracellular location, most of the microRNAs will act as tumor promoters or suppressors by inhibiting the translation process of the target mRNA, thus affecting the behavior of other stromal cells in the tumor microenvironment. At present, growing research focuses on the different types of donor cell sources, their contribution to cancer, miRNA profiling, their biomarker potential, etc. This review aims to state the function of diverse miRNAs in exosomes medicated cell–cell communication and the potency of some specific enriched miRNAs as molecular markers in clinical trials. We also describe the mechanism of anti-cancer compounds through exosomes and the exploration of artificially engineered techniques that lead miRNA-inhibitors into exosomes for therapeutic use.
Persistent Identifierhttp://hdl.handle.net/10722/275453
ISSN
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 1.179
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLIU, Q-
dc.contributor.authorPENG, F-
dc.contributor.authorChen, J-
dc.date.accessioned2019-09-10T02:42:52Z-
dc.date.available2019-09-10T02:42:52Z-
dc.date.issued2019-
dc.identifier.citationInternational Journal of Molecular Sciences, 2019, v. 20 n. 16, p. article no. 3884-
dc.identifier.issn1661-6596-
dc.identifier.urihttp://hdl.handle.net/10722/275453-
dc.description.abstractBreast cancer, ranking first among women’s cancers worldwide, develops from the breast tissue. Study of the breast tissue is, therefore of great significance to the diagnosis and treatment of breast cancer. Exosomes, acting as an effective communicator between cells, are in the ascendant in recent years. One of the most important cargoes contained in the exosomes is microRNAs, belonging to the non-coding RNA family. When the exosomal microRNAs are absorbed into the intracellular location, most of the microRNAs will act as tumor promoters or suppressors by inhibiting the translation process of the target mRNA, thus affecting the behavior of other stromal cells in the tumor microenvironment. At present, growing research focuses on the different types of donor cell sources, their contribution to cancer, miRNA profiling, their biomarker potential, etc. This review aims to state the function of diverse miRNAs in exosomes medicated cell–cell communication and the potency of some specific enriched miRNAs as molecular markers in clinical trials. We also describe the mechanism of anti-cancer compounds through exosomes and the exploration of artificially engineered techniques that lead miRNA-inhibitors into exosomes for therapeutic use.-
dc.languageeng-
dc.publisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms-
dc.relation.ispartofInternational Journal of Molecular Sciences-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectbreast cancer-
dc.subjecttumor microenvironment-
dc.subjectexosomes-
dc.subjectmicroRNA-
dc.subjectbiomarker-
dc.titleThe Role of Exosomal MicroRNAs in the Tumor Microenvironment of Breast Cancer-
dc.typeArticle-
dc.identifier.emailChen, J: abchen@hkucc.hku.hk-
dc.identifier.authorityChen, J=rp01316-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/ijms20163884-
dc.identifier.pmid31395836-
dc.identifier.pmcidPMC6719057-
dc.identifier.scopuseid_2-s2.0-85071282501-
dc.identifier.hkuros305008-
dc.identifier.volume20-
dc.identifier.issue16-
dc.identifier.spagearticle no. 3884-
dc.identifier.epagearticle no. 3884-
dc.identifier.isiWOS:000484411100041-
dc.publisher.placeSwitzerland-
dc.identifier.issnl1422-0067-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats